Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators

Table 2 Predictors of ECC-induced strength loss in isolated EDL and anterior crural muscles of mdx mice

	ECC:ISO	Work	Length/angle change	Contraction velocity	Contraction duration
Ex vivo—(isometric force loss)	0.310 (p < 0.001)	0.563 (p < 0.001)	0.538 (p < 0.001)	0.030 (p = 0.084)	0.455 (p < 0.001)
In vivo—(isometric torque loss)	0.400 (p < 0.001)	0.542 (p < 0.001)	0.780 (p < 0.001)	0.005 (p = 0.606)	0.311 (p < 0.001)

ECC:ISO ratio of maximal eccentric to maximal isometric force
Values = coefficient of determination (R²) following 10 and 70 ECC for ex vivo and in vivo contractions, respectively

ISSN: 2044-5040