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Table 2 Predictors of ECC-induced strength loss in isolated EDL and anterior crural muscles of mdx mice

From: Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators

 ECC:ISOWorkLength/angle changeContraction velocityContraction duration
Ex vivo—(isometric force loss)0.310 (p < 0.001)0.563 (p < 0.001)0.538 (p < 0.001)0.030 (p = 0.084)0.455 (p < 0.001)
In vivo—(isometric torque loss)0.400 (p < 0.001)0.542 (p < 0.001)0.780 (p < 0.001)0.005 (p = 0.606)0.311 (p < 0.001)
  1. ECC:ISO ratio of maximal eccentric to maximal isometric force
  2. Values = coefficient of determination (R2) following 10 and 70 ECC for ex vivo and in vivo contractions, respectively