Murine cell | Canonical Markers | Alternative markers | Negative markers | Localization | Differentiation potential | Additional comments | References |
---|---|---|---|---|---|---|---|
Embryonic-fetal FAPs | PDGFRα TCF7L2/TCF4 Osr1 | Osr2 Hox11 Tbx3 Tbx4 Tbx5 Sca-1a CD34a Adam-12 Tie-2a | CD45 CD31 Ter119 α7-Integrin | Muscle-associated connective tissue and muscle interstitium | Robust in vitro adipogenic and fibrogenic differentiation but low chondrogenic and no detectable osteogenic or myogenic potential. Osr1+ progenitors also give rise to embryonic fibroblast-like cells in the dermis and FABP4+ adipocytes in white fat pads | Little is known about their origin, fate, gene regulation, function, stemness, and self-renewal | |
Adult FAPs | PDGFRα SCA-1 | Hic1 CD90 Decorin (Dcn) PDGFRβb Col1a1b TCF7L2/TCF4b CD34b Adam-12c Tie-2c Gli1d | CD45 CD31 Ter119 α7-Integrin NG2/Cspg4 Rsg5 | Fascia, epimysium, perimysium, and endomysium; abundant as perivascular cells | Adipocytes, myofibroblasts, osteocytes, and chondrocytes after muscle injury and in vitro, with no myogenic potential | Required for adult skeletal muscle regeneration and homeostasis; cellular and molecular dysfunction in pathology and disease | [11, 12, 27, 28]; [1]; [13]; [58]; [14]; [58]; [59]; [60]; [61]; [62], [2, 15, 53, 63, 64]; |