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Table 2 Summary of endogenous human skeletal muscle fibro-adipogenic progenitors

From: Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions

Human cell Canonical Markers Alternative markers Negative markers Localization Differentiation potential Additional comments References
Embryonic-fetal FAPs PDGFRA DCN
FN1
LUM
OSR1
POSTN
FAP
THY1/CD90
VIM
NT5E/CD73
COL1A1
COL1A2
COL3A1
PTN
OGN
FBLN5
PAX3
PAX7
Similar to what is found in mouse development, although not evaluated in detail Not evaluated but probably similar to what is found in mouse development No information about their origin, gene regulation, function, and potency [70]a
Adult FAPs PDGFRA, CD34 (when negative for CD56, CD31 and CD45) CD201
CD166
CD105
CD90
CD73
CD34
CD15
COL1A1
TCF7L2/TCF4
CD31
CD45
CD56
α7-Integrin
NG2/CSPG4
RSG5
Fascia, epimysium, perimysium, and endomysium; abundant as perivascular cells Adipocytes, myofibroblasts, osteocytes, and chondrocytes in diseased states and in vitro. Lack of myogenic potential Increased numbers in diverse pathologies [16]; [51]; [71]; [72]; [52]; [53, 54, 64]
  1. aThese other alternative markers suggested by Pyle and colleagues are based on scRNAseq data (Xi et al., [70])