Fig. 2

NEN restored body weight and muscle mass in the T1D mice. a Body weight of mice was measured every 2 weeks; Repeated measures analyses of variance (ANOVA) were conducted, then post hoc testing was performed using Bonferroni; the T1D mice exhibited decreased bodyweight significantly compared with normal control mice from the 9th day after the injection of STZ (P = 0.000 < 0.001); following the treatment with NEN, body weight of theT1D mice were increasing gradually (P = 0.015 < 0.05). b Representative images of muscle. c Weight of TA muscle. d Weight of GAs muscle. e Weight of EDL muscle. f Weight of SOL muscle. ^**P < 0.01 and ^***P < 0.001 vs. the T1D-Ctrl group. ^#P < 0.05 and ^###P < 0.001 vs. the T1D group. n = 6 in each group