Fig. 6From: The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 geneVolcano plots of differentially expressed miRNA in wt and mdx mice. The analysis was performed for Naive mdx vs Naive wild type (wt) (A) and Givinostat 37.5 mg/kg vs vehicle (B) contrasts after 15 weeks of treatment (T16). Log2 fold-changes estimated by DESeq2 versus –log10 adjusted p values (FDR: false discovery rate) are indicated in the plot. Black dots indicate miRNA with non-significant fold change (FDR > 0.05). Pink dots indicate significantly differentially expressed miRNAs at FDR < 0.05Back to article page