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Fig. 7 | Skeletal Muscle

Fig. 7

From: Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release

Fig. 7

Transcriptomic analyses exhibited that the amiloride treatment improved glycolysis and ketone body oxidation in cachetic gastrocnemius. a Heat-map plot of relative transcription levels of muscular atrophy-related genes (n = 4). b Expressions of ACOT1, CD36, OXCT1, BDH2, and ACAT1 proteins. c Quantification of the expressed proteins (n = 4). Statistical significances: p > 0.05, NS; p < 0.05, *; p < 0.01, **; p < 0.001, ***; p < 0.0001, ****. NOR, C57BL/6 or BALB/c normal control mice; CAC, CT26/LLC cachexia mice; AM, amiloride-treated mice; KD, mice inoculated with Rab27-knockdown CT26/LLC cells; ACOT1, acyl-coenzyme A thioesterase 1; CD36, fatty acid translocase; OXCT1, 3-oxoacid CoA transferase 1; BDH2, 3-hydroxybutyrate dehydrogenase 2; ACAT1, acetyl coenzyme A acetyltransferase 1

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