Table 2 Muscle Disorganization Score (MDS). Each of the structural sites were given a score from 0 to 3, based on the severity of disorganization. MDS for a mutant is the sum of these scores on each site. Left panel refers to WT with normal muscle structure and MDS = 0, while this score is 14 for unc-60(r398) due to the severity of its muscle disorganization. Muscle structure data gathered from literature (see cited references) and unpublished (unpub) data are also included in the table

Phalloidin

(I-band)

MHCA

(A-band)

UNC-95 (base of dense body & M-line)

UNC-89 (M-line)

ATN-1 (Dense body)

MDS

Wild type

0

0

0

0

0

0

uig-1(ok884)

1

1

1

1

1

5

pfn-3(tm1362)

0

1.5

0

0

1

2.5

atn-1(ok84)

2 [44]

0

2 [15]

0 [15]

3 [44]

7

alp-1(tm1137)

1, in 9% [45]

0 [45]

0

0

0 [45]

1

dyc-1(cx32)

0

0

0

1

0

1

dim-1(ra102)

2

3

1

2

1

9

zyx-1(gk190)

0

0

0

0

0

0

tln-1(e259)

0

1

0

0

0

1

unc-95(su33)

3 [68]

3 [68]

3 (PAT-3) [68]

3

3

15

pkn-1(ok1673)

0 [48]

0 [48]

0 [48]

0

0 [48]

0

unc-82(e1220)

2^a [69]

3 [69]

2

3 [69]

0 [69]

10

unc-89(e1460)

2

3 (unpub)

2

3 [39]

1

11

unc-98(sf19)

1

2 [50]

0 [15]

2 [50]

1

6

unc-22(sf21)

0 [51]

0 [51]

0 [51]

0 (unpub)

0 (unpub)

0

unc-22(e66)

2

2 [21]

2 [21]

2 [21]

2 [21]

10

unc-54(s95)

0

1

1

1

1

4

unc-54(s74)

0

1

2

1

1

5

lev-11(x12)

0

1

0

0

0

1

unc-60(r398)

unc-94(sf20)