Fig. 1

Simvastatin treatment does not affect WBC abundance and CK and LDH activity. A Changes in the body weight (BW) over the time of simvastatin treatment; n=10–15/group. Results presented as a percentage of initial weight (mean ± SEM). B Unchanged number of white blood cells (WBC) in the peripheral blood; n=5–6/group. Increased percentage of C granulocytes and D monocytes in dystrophic animals compared to the WT mice without the effect of simvastatin. E Diminished percentage of lymphocytes in dystrophic animals compared to the WT mice without simvastatin-related changes. F Augmented serum activity of CK in mdx animals with no effect of the drug in simvastatin-treated dystrophic mice; n=5–6/group. G Increased serum LDH activity in mdx mice without simvastatin-related alterations; n=5–6/group. Results shown as a mean ± SEM; ^**p < 0.01 and ^****p < 0.0001