Fig. 3
From: Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter
Expression of thyroid hormone transporter-coding genes in select murine skeletal muscle groups. RNA-seq expression data from muscleDB were quantitated and normalized by fragments per kilobase of transcript per million mapped reads (FPKM). The expression of the five transporters is shown: A Slc16a10 (MCT10), B Slc16a2 (MCT8), C Slco1c1 (Oatp1c1), D Slc7a5 (Lat1), and E Slc7a8 (Lat2). Each of six replicates is represented by a dot and the statistical distribution of FPKM values is represented by the boxplot. F qRT-PCR validation of Slc16a10 expression in soleus (Sol), gastrocnemius (Gas), and tibialis anterior (TA) muscles. Expression was normalized over the geometric mean of control genes Actnb and 18S rRNA. Expression in soleus and tibialis anterior is lower than in gastrocnemius, by paired, two-tailed t test (p value < 0.05 shown in red). G-I The expression profiles of Myh1, Myh2, and Myh7 are shown for comparison