Fig. 7

Six1 function is correlated with that of the TH receptor alpha. Gene set enrichment analysis performed on the gene expression profiling of wild-type or Six1-cKO skeletal muscle (Sakakibara et al.), using two custom sets representing genes that are significantly less or more expressed in Thra knock-out skeletal muscle treated with T3 compared to wild-type T3-treated muscle (from Nicolaisen et al.). A Enrichment score graph showing that when genes are ranked from the most downregulated in Six1-cKO to the most upregulated, the beginning of the list is enriched in genes that are more expressed in T3-treated wild-type muscle compared to Thra-cKO muscle. B Heat map of the genes that contribute the most to the enrichment shown in panel A (“core enrichment” genes). The gene order from top to bottom in the heatmap follows the order from left to right in panel A. C and D Similar analyses as in A and B but for the set representing genes that are more expressed in Thra-cKO compared to WT. The gene symbols shown in panels B and D are listed in supplementary files Code_S3 and Code_S4