Table 3 Comparison of muscles from old and adult mice: the top 10 canonical pathways identified from the IPA knowledge database that involve DE (adjusted P < 0.05 and 1.4 log2 fold change) protein coding genes
From: Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing
Ingenuity Canonical Pathways | -log(p-value) | Ratio |
|---|---|---|
Insulin Receptor Signalling | 2.48 | 0.06 |
AMPK Signalling | 2.44 | 0.05 |
Geranylgeranyldiphosphate Biosynthesis | 1.95 | 1.00 |
Dopamine Receptor Signalling | 1.87 | 0.07 |
IL-9 Signalling | 1.86 | 0.13 |
Apelin Liver Signalling Pathway | 1.81 | 0.12 |
Th1 Pathway | 1.72 | 0.06 |
Type II Diabetes Mellitus Signalling | 1.66 | 0.04 |
Trans, trans-farnesyl Diphosphate Biosynthesis | 1.65 | 0.50 |
Role of JAK2 in Hormone-like Cytokine Signalling | 1.63 | 0.10 |