Table 4 Comparison of muscle from control adult mice and adult mice following nerve crush: the top 10 canonical pathways from the IPA knowledge database that involve DE (adjusted P < 0.05 and 1.4 log2 fold change) protein coding genes
From: Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing
Ingenuity Canonical Pathways | -log(p-value) | Ratio |
|---|---|---|
TCA Cycle II (Eukaryotic) | 8.62 | 1 |
EIF2 Signalling | 3.63 | 0.44 |
mTOR Signalling | 3.13 | 0.42 |
Oestrogen Receptor Signalling | 2.54 | 0.38 |
Sirtuin Signalling Pathway | 2.34 | 0.38 |
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages | 2.26 | 0.41 |
D-myo-inositol-5-phosphate Metabolism | 2.08 | 0.42 |
3-phosphoinositide Degradation | 2.05 | 0.41 |
D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis | 2.01 | 0.42 |
D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis | 2.01 | 0.42 |