Table 5 Comparison of muscle from control old mice and old mice following nerve crush: the top 10 canonical pathways from the IPA knowledge database that involve DE (adjusted P < 0.05 and 1.4 log2 fold change) protein coding genes
From: Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing
Ingenuity Canonical Pathways | -log(p-value) | Ratio |
|---|---|---|
Oxidative Phosphorylation | 17.1 | 0.33 |
Mitochondrial Dysfunction | 13.8 | 0.23 |
Sirtuin Signalling Pathway | 7.56 | 0.14 |
Glycolysis I | 3.46 | 0.31 |
Aryl Hydrocarbon Receptor Signalling | 3.31 | 0.13 |
Glycogen Degradation II | 3.19 | 0.6 |
Calcium Signalling | 3.13 | 0.11 |
Xenobiotic Metabolism PXR Signalling Pathway | 2.92 | 0.12 |
Glycogen Degradation III | 2.9 | 0.5 |
Pyruvate Fermentation to Lactate | 2.77 | 1 |