Fig. 6
From: Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years
Genome wide association study (GWAS) for the asymmetric dimethylarginine (ADMA) in the 77 OA patients from the NFOAS: A a Manhattan plot of the GWAS results. The red line indicates the GWAS significance at α = 5 × 10−8, B the regional association plot for the chromosomal region around the most significant SNP rs1125718 on chromosome 8 (p=4.394*10-8) showing adjacent NDRG1, WISP1, ST3GAL1, and ZFAT genes, and C the regional association plot for the chromosomal region around the second most significant SNP rs816296 on chromosome 12 (p=2.03*10-6). This SNP is an intronic variant located in intron 1 of NOS1 gene