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Table 4 Top metabolites associated with the muscle strength change measures in the study participants (n=409) over 10-year follow-up time

From: Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years

Muscle strength change

(Metabolite*follow-up time)a

Beta

SE

P value

A) Hand grip

Asymmetric dimethylarginine

−0.053

0.015

0.0003

Total dimethylarginine

−0.049

0.014

0.0006

Taurine

0.033

0.014

0.015

Lactic acid

0.029

0.014

0.04

B) Knee extension

Total dimethylarginine

−0.119

0.044

0.007

Asymmetric dimethylarginine

−0.119

0.045

0.008

Methylmalonic acid

−0.085

0.046

0.07

C3:1

−0.084

0.046

0.07

C) Leg strength

Uric acid

−0.633

0.157

0.0001

PC aa 32:2

0.586

0.168

0.0005

Creatinine

−0.581

0.168

0.0006

Methionine

−0.551

0.168

0.001

  1. aAn interaction term between metabolite values and follow-up time used as predictors for longitudinal changes in muscle strength. C3:1 acrylylcarnitine, PC aa 32:2 phosphatidylcholine acyl-acyl with 32 carbons and 2 double bonds