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Fig. 1 | Skeletal Muscle

Fig. 1

From: Effect of chronic intermittent hypoxia (CIH) on neuromuscular junctions and mitochondria in slow- and fast-twitch skeletal muscles of mice—the role of iNOS

Fig. 1

Representative images (200-fold magnification, scale bar = 50 μm) of soleus muscle cross sections stained for ATPase after preincubation at pH 4.55 of WT-NOX mouse (A), WT-CIH mouse (B), iNOS−/−-NOX mouse (C), and iNOS−/−-CIH mouse (D). Type 1 fibers are stained dark (white arrow), type 2a fibers are stained light-colored (black star), and type 2x fibers are stained intermediate (black arrowhead). E Overall myofiber CSA [μm2] and F CSA of type 2a myofibers in the soleus muscle of WT and iNOS−/− mice. Fiber-type distribution [%] in the soleus muscle. Percentage of type 1, type 2a, and type 2x fibers of WT mice after 6 weeks of CIH compared with NOX controls (G) and of iNOS−/− mice (H). Values are given as mean + SEM; n = 8 to 14 animals per group. *p < 0.05, **p < 0.01, ***p < 0.001, significance between CIH and NOX

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