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Fig. 1 | Skeletal Muscle

Fig. 1

From: Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress

Fig. 1

Juvenile mice display similar activity and body mass changes following 1-month VWR exercise despite irradiation. a Experimental design of juvenile fractionated radiation 3× 8.2 Gy, (M, W, F) on 1-month-old WT C57Bl6/j mice followed by 1 month of voluntary wheel running (VWR) exercise at 2 months of age. Mice were sacrificed at 3 months of age. Non-irradiated mice and mice unable to engage with the running wheel were used as radiation and exercise controls, respectively. b Small Animal Radiation Research Platform (SARRP) image displaying area of localized X-ray irradiation. c Running activity of irradiated and control non-irradiated mice. Each dot is representative of one mouse. d Percent day running of irradiated and control non-irradiated mice. Each dot represents one mouse. e Change in body mass (g) following 1-month VWR exercise. Each dot is representative of one mouse. Two-way ANOVA with multiple comparisons ****p < 0.0001. Isolated asterisks denote the ANOVA group effect of exercise. Data is displayed as mean ± s.e.m

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