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Fig. 1 | Skeletal Muscle

Fig. 1

From: Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension

Fig. 1

MCT-induced PAH caused body weight loss and muscle atrophy. A Circulating GDF11 levels in PAH patients and health control (n=8). B RVSP of rats 4 weeks after MCT-treated, C body weight, and D the weight of gastrocnemius muscle, soleus muscle, tibialis anterior, and Extensor Digitorum Longus normalized per body weight (BW). E The weight of gastrocnemius muscle. F Representative images of EDL, TA, Sol, GM, and the cross-sectional areas of approximately 250 myofibers per group were determined. Scale bar represents 25 μm. G The distribution of myofiber cross-sectional area. n = 8 rats/group. Data are shown as mean ± SEM. Versus vehicle control, *P < 0.05, **P < 0.01, ***P < 0.001

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Skeletal Muscle

ISSN: 2044-5040

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