Fig. 4

DAS, more than DGE, is associated with the chronic physiological adaptations of both the gastrocnemius and quadriceps to microgravity. Combined table and bar graphs depict the overall number of DGE and DAS events in genes encoding proteins with known functions in skeletal muscle. Events were categorized into four groups based on previous research suggesting the expression of their encoded protein isoforms (i) accompany muscle atrophy (blue), (ii) are associated with altered fiber type function (green), (iii) are thought to compromise the function of musculoskeletal splicing regulators (yellow), or (iv) have an unknown or unrelated perturbation (orange). The size of the colored sections of the bar graphs is representative of the number of events for each event category as shown in the table below. The cumulative height of the bar graphs is representative of the overall number of potentially functionally significant DGE or DAS events, regardless of category, in each muscle