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Table 2 DAS of skeletal muscle genes in the gastrocnemius of spaceflown mice. Thirty-two significant DAS events were identified in 15 genes encoding proteins with known functions in skeletal muscle in the gastrocnemius between flight and ground control groups. DAS events were categorized into four groups based on previous research suggesting the expression of their encoded protein isoforms i) accompany muscle atrophy, ii) are associated with altered fiber type function, iii) are thought to compromise the function of musculoskeletal splicing regulators, or iv) have an unknown or unrelated perturbation. DAS events were identified by gene symbol, gene name, event type (SE, skipped exon; MXE, mutually exclusive exons), and involved exon(s). △PSI (change in percent spliced in of a specific exon) values (positive values, more inclusion in flight as compared to ground; negative values, less inclusion in flight as compared to ground) as well as FDR (false discovery rate-adjusted p-values) are provided for each DAS event. Parentheses with numerical values next to SE or MXE denotations [e.g., SE (8)] correspond to genes with multiple DAS events. For these genes, regions (e.g., 3′ variable region) rather than specific exons are provided. Genes are ordered by significance of DAS as measured by FDR

From: Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight