Fig. 6

Overlap between dysregulated genes involved in myopathy, myogenesis, and glucose metabolism in skeletal muscle of Smn^−/−;SMN2, Fn14^−/−, and Tweak^−/− mice. a Venn diagram showing overlap of genes involved in myopathy and myogenesis that are significantly dysregulated in the same direction (either up or downregulated, p < 0.05) in triceps and quadriceps muscle from postnatal day (P) 7 compared to Smn^−/−;SMN2, Fn14^−/−, and Tweak^−/− mice to age- and genetic strain-matched wild-type (WT) mice. b Network and enrichment analysis of the overlap of significantly dysregulated myopathy and myogenesis genes in triceps and/or quadriceps of P7 Smn^−/−;SMN2, Fn14^−/−, and Tweak^−/− mice using STRING software. Smn (Smn1), TWEAK (Tnfsf12), and Fn14 (Tnfrsf12a) are included in the analysis. Colored nodes represent query proteins and first shell of interactors. Filled nodes indicate that some 3D structure is known or predicted. Connection colored lines between nodes represent either known interactions (turquoise: from curated databases, magenta: experimentally determined), predicted interactions (green: gene neighborhood, red: gene fusions, dark blue: gene co-occurrence) or other interactions (yellow: textmining, black: co-expression, light blue: protein homology). c Venn diagram showing overlap of genes involved in glucose metabolism that is significantly dysregulated in the same direction (either up or downregulated, p < 0.05) in triceps and quadriceps muscle from P7 compared to Smn^−/−;SMN2, Fn14^−/−, and Tweak^−/− mice to age- and genetic strain-matched WT mice. d Network and enrichment analysis of the overlap of significantly dysregulated myopathy and myogenesis genes in triceps and/or quadriceps of P7 Smn^−/−;SMN2, Fn14^−/−, and Tweak^−/− mice using STRING software. Smn (Smn1), TWEAK (Tnfsf12), Fn14 (Tnfrsf12a), HKII (Hk2), Glut4 (Slc2a4), Pgc-1α (Ppargc1a), Klf15, and Mef2d are included in the analysis. Colored nodes represent query proteins and first shell of interactors. Filled nodes indicate that some 3D structure is known or predicted. Connection colored lines between nodes represent either known interactions (turquoise: from curated databases, magenta: experimentally determined), predicted interactions (green: gene neighborhood, red: gene fusions, dark blue: gene co-occurrence) or other interactions (yellow: textmining, black: co-expression, light blue: protein homology)