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Table 3 KEGG pathways generated from glucose metabolism genes that were significantly dysregulated in the same direction in triceps and quadriceps of P7 Smn−/−;SMN2, Fn14−/− and Tweak−/− mice when compared to P7 WT mice

From: Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice

Pathway ID

Pathway description

Count in gene set

False discovery rate (FDR)

01200

Carbon metabolism

13

7.62e-22

01120

Microbial metabolism in diverse environments

13

1.87e-19

00010

Glycolysis/Gluconeogenesis

8

2.09e-13

00020

Citrate cycle (TCA cycle)

7

2.09e-13

01100

Metabolic pathways

16

7.65e-13

01230

Biosynthesis of amino acids

7

8.75e-11

00051

Fructose and mannose metabolism

5

1.7e-08

04910

Insulin signaling pathway

6

3.09e-07

00500

Starch and sucrose metabolism

4

8.58e-06

04152

AMPK signaling pathway

5

8.58e-06

01210

2-Oxocarboxylic acid metabolism

3

2.79e-05

00030

Pentose phosphate pathway

3

0.000126

04066

HIF-1 signaling pathway

4

0.000141

00052

Galactose metabolism

3

0.000145

04920

Adipocytokine signaling pathway

3

0.00138

00620

Pyruvate metabolism

2

0.0177

04973

Carbohydrate digestion and absorption

2

0.0177

04930

Type II diabetes mellitus

2

0.0227

00310

Lysine degradation

2

0.0233