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Fig. 3 | Skeletal Muscle

Fig. 3

From: Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin–p53 interaction

Fig. 3

Attenuated denervated muscle atrophy using P53 KO. A, B Appearance and loss of gastrocnemius muscle weight of WT mice control, the P53 KO and WT mice at 1 and 2 weeks post-denervation. *P<0.05 versus Den (n=6/group). C, D, E, F HE staining of the muscle tissue, mean ± SEM fiber area, mean fiber diameter, and mean fiber density showing muscle atrophy that was ameliorated by p53 KO. *P<0.05 versus control; #P<0.05 versus Den (n=6/group). Scale bar, 50 μm. G–H The expression of MuRF1 and MAFbx mRNA in the P53 KO and WT mice at 1 week post-denervation was determined by qPCR, showing muscle atrophy was ameliorated by p53 KO. *P<0.05 versus control; #P<0.05 versus Den (n=6/group) WT, wild type; KO, knockout

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Skeletal Muscle

ISSN: 2044-5040

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