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Fig. 5 | Skeletal Muscle

Fig. 5

From: Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells

Fig. 5

Continuous FOS activity leads to switching of A/B compartments near FOS regulated genes in muscle progenitor cells. A Pie chart showing the percentage of compartmental switching events between pSLIK-Gfp and pSLIK-Fos muscle progenitor cells. B Compartmentalization plot for chromosome 1 (168.9-197.1 megabases) showing the 1st eigenvector, where the positive values represent the open “A-type” and the negative values represent the closed “B-type” compartments, suggesting that while most of the A/B compartments in this genomic interval are unchanged, there are several examples of compartment switching events (dashed boxes) between the two conditions. C Bar plot showing the density of the normalized number of differentially expressed genes, based on RNA-seq data, at stable, or switched (i.e., A to B or B to A) compartmental regions (p-value: one-way ANOVA). D Box plot showing the average pSLIK-Fos vs. pSLIK-Gfp log2FC RNA-seq values for genes (outliers removed) within either stable compartments, or compartments that have switched from open to closed (A to B), and vice versa (B to A). p value: Wilcoxon rank-sum test

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Skeletal Muscle

ISSN: 2044-5040

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