Skip to main content
Fig. 7 | Skeletal Muscle

Fig. 7

From: Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells

Fig. 7

Elevated FOS activity alters gene loops near myogenic genes in muscle progenitor cells. A A meta plot showing the average loops (depicted as dots) in pSLIK-Gfp and pSLIK-Fos muscle progenitor cells. B Venn diagram showing the number of overlapping and differentially regulated loops in pSLIK-Gfp and pSLIK-Fos muscle progenitor cells. C Meta plots of all loops that have been lost or gained in pSLIK-Fos cells, showing loops weakened and strengthened in presence of FOS. D Bar plot showing the number of differentially expressed genes up to 100 kb around the differentially regulated loops at 25 kb intervals. Majority of the FOS-mediated differentially expressed genes are located within altered genomic loops. E Plot showing the GO term enrichment of differentially expressed genes within 25 kb distance of differentially regulated loops. F Heatmap at 20 kb resolution of GFP and FOS Hi-C datasets showing a strengthening of a loop formation at the Pax7 gene locus, which is associated with a decrease in Pax7 gene expression with a log fold-change value of − 0.9. The z-scores of the looping interaction are depicted on the figure

Back to article page

Skeletal Muscle

ISSN: 2044-5040

Contact us