Fig. 3
From: Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience
Comparison of NMJ loss in four mouse models indicates a similar range of vulnerability. A–D Bar charts showing the percentage of fully occupied endplates in previously investigated muscles in the Smn-/-;SMN2 [14, 24, 25]; * = [14, 24], # = [25], Taiwanese [16, 29], SMN∆7 [14, 16, 20, 28]; = [20]; + = [28] and Smn2B/- [16, 27] mouse model, respectively. The muscles in each mouse model are ordered by decreasing percentage of fully occupied endplates. Each muscle is coloured according to its classification category by percentage of fully occupied motor endplates present at end-stage of disease. Each of the four mouse models displays a wide variability in the percentage of NMJ loss and therefore in vulnerability levels. Note that the percentage of fully occupied endplates ranges from almost 100% to lowest values of only around 20–30% in all four models