Fig. 5
From: Mouse models of SMA show divergent patterns of neuronal vulnerability and resilience
Transcriptional analysis shows enriched genes associated with rRNA processing, and vesicle trafficking and neuronal development. A Expression heatmap of the 433 DEGs between motor neurons from the CNVII in Smn2B/-. Relative expression levels in the thoracic spinal cord in Smn2B/- and the CNVII in SMN∆7 compared to their respective controls are also shown. Expression values were normalized and mean centred. B Venn diagram showing number of overlapping identified DEGs in all three motor neuron groups. Gene ontology analysis was done on changes found exclusively in the CNVII motor neurons from Smn2B/- mice (384 DEGs). C Gene ontology (GO) term analysis for biological functions of the 384 differentially expressed genes in the CNVII of Smn2B/- mice compared to CNVII of control mice. The size of the dot in the diagram reflects the number of genes included in the GO term. The colour of the dot shows the significance of the adjusted p value. Heatmaps with hierarchical clustering of D the 16 genes that are included in the GO terms ‘ribonucleoprotein complex biogenesis;’ E the 16 genes associated with the GO term cluster ‘protein localisation to cell periphery’. In both heatmaps, Z scores are calculated and plotted instead of the normalized expression value only. Note that in both heatmaps the Smn2B/- CNVII samples are altered in comparison to their controls, while there is no difference between SMN∆7 and their controls