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Fig. 6 | Skeletal Muscle

Fig. 6

From: Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice

Fig. 6

Simvastatin did not attenuate LGMD2B-associated quadriceps or triceps histopathology in hyperlipidemic HFD-fed Dysf-null mice. A Representative images of and B quantification of percentage fat, damaged and healthy myofiber areas, and the percentage of collaged deposition in whole quadriceps and tricep muscles from HFD-fed WT and Dysf mice treated with either vehicle or SIM. Scale 1 mm for whole muscle images and 200 μm for insets. Two-way ANOVA with Sidak’s post hoc tests were used for direct comparisons between WT and Dysf mice; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Mean ± SEM. A–BN = 7–9

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