Fig. 9

No effect of simvastatin on the liver expression of HMGCR or LDLR. A Representative images and immunoblot quantification of HMGCR and LDLR in the livers of Chow-fed, WT and Dysf mice treated with either vehicle or simvastatin. Two-way ANOVA with Sidak’s post hoc tests were used for direct mean comparisons; no significance. B Representative images and immunoblot quantification of HMGCR and LDLR in the livers of Chow-fed, WT, and Dysf mice treated with either vehicle or simvastatin. Two-way ANOVA with Sidak’s post hoc tests were used for direct mean comparisons; no significance. HMGCR and LDLR were standardized to the loading control GAPDH. Y-axes represent arbitrary units (AU). Full blots were imaged separately and thus have differing exposures. A common sample was loading onto each gel to normalize for detection efficiencies across membranes. Mean ± SEM. N = 3 for each cohort