Skip to main content

Table 2 Effect of HFD-feeding and simvastatin treatment on relative muscle weights in C57BL/6 and Dysf-null mice aged 11 months

From: Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice

 

Vehicle

Simvastatin

WT

Dysf

WT

Dysf

Chow

 Quadriceps

12.4 ± 0.4

10.6 ± 0.4

12.4 ± 0.7

10.2 ± 0.8

 Gastrocnemius

8.7 ± 0.4

9.4 ± 0.6

8.7 ± 0.4

8.2 ± 0.7

 Tibialis anterior

3.1 ± 0.2

3.0 ± 0.2

2.9 ± 0.1

2.8 ± 0.1

 Triceps brachii

6.6 ± 0.3

7.1 ± 0.3

6.6 ± 0.5

6.4 ± 0.4

HFD

 Quad

12.6 ± 0.3

9.3 ± 0.5*

12.6 ± 0.6

9.0 ± 0.8*

 Gastrocnemius

9.0 ± 0.2

8.2 ± 0.4*

9.6 ± 0.3

7.5 ± 0.4*

 Tibialis anterior

2.7 ± 0.1

2.8 ± 0.1

3.0 ± 0.2

2.9 ± 0.1

 Triceps brachii

6.7 ± 0.3

6.3 ± 0.6

6.9 ± 0.3

5.9 ± 0.3

  1. Muscle weights (mg) were weighed and quantified relative to tibia length (mm). Data are mean ± SEM. Asterisk (*) indicates significantly different compared to C57BL/6 (WT) cohorts for each listed parameter (*) P < 0.5; two-way ANOVA with Tukey’s post hoc tests. No significant differences between Chow and HFD cohorts were detected; two-way ANOVA with Sidak’s post hoc tests