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Fig. 1 | Skeletal Muscle

Fig. 1

From: Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways

Fig. 1

Overview of RNA sequencing and mass spectrometry reveals distinct transcriptomic and proteomic profiles of SSPN overexpression rescue. a Principal component analysis (PCA) of RNA sequencing data in wild type (WT, n = 5), mdx (n = 4), and mSSPN transgenic (mdxTG, n = 4) tibialis anterior muscle at 12 weeks of age. b Heat map of DEGs. c PCA of mass spectrometry data from WT (n = 5), mdx (n = 5), and hSSPN transgenic (mdxTG, n = 5) quadriceps muscle at 20 weeks of age. d Heat map of differentially expressed proteins (DEPs). e Overlap of Gene Ontology (GO) terms enriched in WT vs mdxTG in transcriptomics vs proteomics data using PANTHER GO analysis platform

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