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  1. Research

    Muscle-specific deletion of SOCS3 increases the early inflammatory response but does not affect regeneration after myotoxic injury

    Muscles of old animals are injured more easily and regenerate poorly, attributed in part to increased levels of circulating pro-inflammatory cytokines. The Janus kinase/signal transducers and activators of tra...

    Kristy Swiderski, Savant S. Thakur, Timur Naim, Jennifer Trieu, Annabel Chee, David I. Stapleton, René Koopman and Gordon S. Lynch

    Skeletal Muscle 2016 6:36

    Published on: 24 October 2016

  2. Research

    VAChT overexpression increases acetylcholine at the synaptic cleft and accelerates aging of neuromuscular junctions

    Cholinergic dysfunction occurs during aging and in a variety of diseases, including amyotrophic lateral sclerosis (ALS). However, it remains unknown whether changes in cholinergic transmission contributes to a...

    Satoshi Sugita, Leland L. Fleming, Caleb Wood, Sydney K. Vaughan, Matheus P. S. M. Gomes, Wallace Camargo, Ligia A. Naves, Vania F. Prado, Marco A. M. Prado, Cristina Guatimosim and Gregorio Valdez

    Skeletal Muscle 2016 6:31

    Published on: 5 October 2016

  3. Research

    Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration

    The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan express...

    Addolorata Pisconti, Glen B. Banks, Farshad Babaeijandaghi, Nicole Dalla Betta, Fabio M. V. Rossi, Jeffrey S. Chamberlain and Bradley B. Olwin

    Skeletal Muscle 2016 6:34

    Published on: 4 October 2016

  4. Research

    Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle

    Adult skeletal muscles are composed of slow and fast myofiber subtypes which each express selective genes required for their specific contractile and metabolic activity. Six homeoproteins are transcription fac...

    Iori Sakakibara, Maud Wurmser, Matthieu Dos Santos, Marc Santolini, Serge Ducommun, Romain Davaze, Anthony Guernec, Kei Sakamoto and Pascal Maire

    Skeletal Muscle 2016 6:30

    Published on: 5 September 2016

  5. Research

    Failed reinnervation in aging skeletal muscle

    Skeletal muscle displays a marked accumulation of denervated myofibers at advanced age, which coincides with an acceleration of muscle atrophy.

    Sudhakar Aare, Sally Spendiff, Madhusudanarao Vuda, Daren Elkrief, Anna Perez, Qinghua Wu, Dominique Mayaki, Sabah N. A. Hussain, Stefan Hettwer and Russell T. Hepple

    Skeletal Muscle 2016 6:29

    Published on: 1 September 2016

  6. Research

    ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments

    Cachexia affects the majority of patients with advanced cancer and is associated with reduced treatment tolerance, response to therapy, quality of life, and life expectancy. Cachectic patients with advanced ca...

    Shinji Hatakeyama, Serge Summermatter, Marie Jourdain, Stefan Melly, Giulia C. Minetti and Estelle Lach-Trifilieff

    Skeletal Muscle 2016 6:26

    Published on: 26 July 2016

  7. Research

    Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle

    The greater susceptibility to contraction-induced skeletal muscle injury (fragility) is an important dystrophic feature and tool for testing preclinic dystrophin-based therapies for Duchenne muscular dystrophy...

    Pauline Roy, Fredérique Rau, Julien Ochala, Julien Messéant, Bodvael Fraysse, Jeanne Lainé, Onnik Agbulut, Gillian Butler-Browne, Denis Furling and Arnaud Ferry

    Skeletal Muscle 2016 6:23

    Published on: 20 July 2016

  8. Methodology

    Characterization of a Dmd EGFP reporter mouse as a tool to investigate dystrophin expression

    Dystrophin is a rod-shaped cytoplasmic protein that provides sarcolemmal stability as a structural link between the cytoskeleton and the extracellular matrix via the dystrophin-associated protein complex (DAPC...

    Mina V. Petkova, Susanne Morales-Gonzales, Karima Relizani, Esther Gill, Franziska Seifert, Josefine Radke, Werner Stenzel, Luis Garcia, Helge Amthor and Markus Schuelke

    Skeletal Muscle 2016 6:25

    Published on: 5 July 2016

  9. Research

    Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that is typically fatal within 3–5 years of diagnosis. While motoneuron death is the defining characteristic of ALS, the events ...

    Donald Beqollari, Christin F. Romberg, Gabriella Dobrowolny, Martina Martini, Andrew A. Voss, Antonio Musarò and Roger A. Bannister

    Skeletal Muscle 2016 6:24

    Published on: 23 June 2016

  10. Research

    Treatment with rGDF11 does not improve the dystrophic muscle pathology of mdx mice

    Duchenne muscular dystrophy (DMD) is an inherited lethal muscle wasting disease characterized by cycles of degeneration and regeneration, with no effective therapy. Growth differentiation factor 11 (GDF11), a ...

    Fabrizio Rinaldi, Yu Zhang, Ricardo Mondragon-Gonzalez, Jeffrey Harvey and Rita C. R. Perlingeiro

    Skeletal Muscle 2016 6:21

    Published on: 14 June 2016

  11. Research

    Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

    Secondary dystroglycanopathies are a subset of muscular dystrophy caused by abnormal glycosylation of α-dystroglycan (αDG). Loss of αDG functional glycosylation prevents it from binding to laminin and other ex...

    Steven J. Foltz, Junna Luan, Jarrod A. Call, Ankit Patel, Kristen B. Peissig, Marisa J. Fortunato and Aaron M. Beedle

    Skeletal Muscle 2016 6:20

    Published on: 2 June 2016

  12. Research

    The SH3 and cysteine-rich domain 3 (Stac3) gene is important to growth, fiber composition, and calcium release from the sarcoplasmic reticulum in postnatal skeletal muscle

    The SH3 and cysteine-rich domain 3 (Stac3) gene is specifically expressed in the skeletal muscle. Stac3 knockout mice die perinatally. In this study, we determined the potential role of Stac3 in postnatal skeleta...

    Xiaofei Cong, Jonathan Doering, Davi A. G. Mazala, Eva R. Chin, Robert W. Grange and Honglin Jiang

    Skeletal Muscle 2016 6:17

    Published on: 11 April 2016

  13. Research

    Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle

    Electrical activity regulates the expression of skeletal muscle genes by a process known as “excitation-transcription” (E-T) coupling. We have demonstrated that release of adenosine 5′-triphosphate (ATP) durin...

    Manuel Arias-Calderón, Gonzalo Almarza, Alexis Díaz-Vegas, Ariel Contreras-Ferrat, Denisse Valladares, Mariana Casas, Héctor Toledo, Enrique Jaimovich and Sonja Buvinic

    Skeletal Muscle 2016 6:15

    Published on: 11 April 2016

  14. Review

    The beneficial role of proteolysis in skeletal muscle growth and stress adaptation

    Muscle atrophy derived from excessive proteolysis is a hallmark of numerous disease conditions. Accordingly, the negative consequences of skeletal muscle protein breakdown often overshadow the critical nature ...

    Ryan A. V. Bell, Mohammad Al-Khalaf and Lynn A. Megeney

    Skeletal Muscle 2016 6:16

    Published on: 6 April 2016

    The Erratum to this article has been published in Skeletal Muscle 2016 6:19

  15. Research

    Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures

    Myostatin (Mstn) is a negative regulator of muscle growth whose inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in which myostatin is knocked out or inhibited postnatally have a ...

    Joe N. Kornegay, Daniel J. Bogan, Janet R. Bogan, Jennifer L. Dow, Jiahui Wang, Zheng Fan, Naili Liu, Leigh C. Warsing, Robert W. Grange, Mihye Ahn, Cynthia J. Balog-Alvarez, Steven W. Cotten, Monte S. Willis, Candice Brinkmeyer-Langford, Hongtu Zhu, Joe Palandra…

    Skeletal Muscle 2016 6:14

    Published on: 4 April 2016

  16. Research

    Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis

    Diabetes is the seventh leading cause of death in the USA, and disruption of circadian rhythms is gaining recognition as a contributing factor to disease prevalence. This disease is characterized by hyperglyce...

    Brianna D. Harfmann, Elizabeth A. Schroder, Maureen T. Kachman, Brian A. Hodge, Xiping Zhang and Karyn A. Esser

    Skeletal Muscle 2016 6:12

    Published on: 30 March 2016

  17. Research

    Chromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation

    Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although or...

    Jessica Segalés, Abul B. M. M. K. Islam, Roshan Kumar, Qi-Cai Liu, Pedro Sousa-Victor, F. Jeffrey Dilworth, Esteban Ballestar, Eusebio Perdiguero and Pura Muñoz-Cánoves

    Skeletal Muscle 2016 6:9

    Published on: 15 March 2016

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