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  1. Content type: Research

    Previous studies in patients with limb-girdle muscular dystrophy type 2A (LGMD2A) have suggested that calpain-3 (CAPN3) mutations result in aberrant regeneration in muscle.

    Authors: Mehmet E. Yalvac, Jakkrit Amornvit, Cilwyn Braganza, Lei Chen, Syed-Rehan A. Hussain, Kimberly M. Shontz, Chrystal L. Montgomery, Kevin M. Flanigan, Sarah Lewis and Zarife Sahenk

    Citation: Skeletal Muscle 2017 7:27

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  2. Content type: Research

    The mouse is one of the most widely used animal models to study neuromuscular diseases and test new therapeutic strategies. However, findings from successful pre-clinical studies using mouse models frequently ...

    Authors: Xiao Hu, James P. Charles, Turgay Akay, John R. Hutchinson and Silvia S. Blemker

    Citation: Skeletal Muscle 2017 7:26

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  3. Content type: Research

    The treatments currently approved for Duchenne muscular dystrophy (DMD), a progressive skeletal muscle wasting disease, address the needs of only a small proportion of patients resulting in an urgent need for ...

    Authors: Michael St. Andre, Mark Johnson, Prashant N. Bansal, Jeremy Wellen, Andrew Robertson, Alan Opsahl, Peter M. Burch, Peter Bialek, Carl Morris and Jane Owens

    Citation: Skeletal Muscle 2017 7:25

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  4. Content type: Research

    Chronic increases in the levels of the inflammatory cytokine interleukin-6 (IL-6) in serum and skeletal muscle are thought to contribute to the progression of muscular dystrophy. Dystrophin/utrophin double-kno...

    Authors: Eiji Wada, Jun Tanihata, Akira Iwamura, Shin’ichi Takeda, Yukiko K. Hayashi and Ryoichi Matsuda

    Citation: Skeletal Muscle 2017 7:23

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  5. Content type: Research

    Duchenne muscular dystrophy (DMD) is a lethal X-linked muscle wasting disorder caused by the absence of dystrophin, a large cytoskeletal muscle protein. Increasing the levels of the dystrophin-related-protein ...

    Authors: Tahnee L. Kennedy, Lee Moir, Sarah Hemming, Ben Edwards, Sarah Squire, Kay Davies and Simon Guiraud

    Citation: Skeletal Muscle 2017 7:22

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  6. Content type: Research

    The hepatocyte growth factor (HGF) is required for the activation of muscle progenitor cells called satellite cells (SC), plays a role in the migration of proliferating SC (myoblasts), and is present as a solu...

    Authors: Mariela Natacha González, Wallace de Mello, Gillian S. Butler-Browne, Suse Dayse Silva-Barbosa, Vincent Mouly, Wilson Savino and Ingo Riederer

    Citation: Skeletal Muscle 2017 7:20

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  7. Content type: Research

    Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin expression and leads to severe ambulatory and cardiac function decline. However, the dystrophin-deficient mdx murine model of DMD only develops a ...

    Authors: Nadia Milad, Zoe White, Arash Y. Tehrani, Stephanie Sellers, Fabio M.V. Rossi and Pascal Bernatchez

    Citation: Skeletal Muscle 2017 7:19

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  8. Content type: Research

    Regeneration of adult tissues relies on adult stem cells that are primed to enter a differentiation program, while typically remaining quiescent. In mouse skeletal muscle, these features are reconciled by mult...

    Authors: Ryo Fujita, Victoria Zismanov, Jean-Marie Jacob, Solène Jamet, Krum Asiev and Colin Crist

    Citation: Skeletal Muscle 2017 7:18

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  9. Content type: Research

    In contrast to the acute effects of growth hormone (GH) on skeletal muscle protein synthesis, long-term GH treatment appears to have negligible effects on muscle mass. Despite this knowledge, little is known r...

    Authors: Leslie A. Consitt, Alicson Saneda, Gunjan Saxena, Edward O. List and John J. Kopchick

    Citation: Skeletal Muscle 2017 7:17

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  10. Content type: Research

    Facioscapulohumeral dystrophy (FSHD) is a progressive muscle disease caused by mutations that lead to epigenetic derepression and inappropriate transcription of the double homeobox 4 (DUX4) gene in skeletal muscl...

    Authors: Amy E. Campbell, Jonathan Oliva, Matthew P. Yates, Jun Wen Zhong, Sean C. Shadle, Lauren Snider, Nikita Singh, Shannon Tai, Yosuke Hiramuki, Rabi Tawil, Silvère M. van der Maarel, Stephen J. Tapscott and Francis M. Sverdrup

    Citation: Skeletal Muscle 2017 7:16

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  11. Content type: Research

    Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of inherited autosomal myopathies that preferentially affect voluntary muscles of the shoulders and hips. LGMD has been clinically described i...

    Authors: Melissa L. Cox, Jacquelyn M. Evans, Alexander G. Davis, Ling T. Guo, Jennifer R. Levy, Alison N. Starr-Moss, Elina Salmela, Marjo K. Hytönen, Hannes Lohi, Kevin P. Campbell, Leigh Anne Clark and G. Diane Shelton

    Citation: Skeletal Muscle 2017 7:15

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  12. Content type: Research

    Pax7+ satellite cells are required for skeletal muscle fiber growth during post-natal development in mice. Satellite cell-mediated myonuclear accretion also appears to persist into early adulthood. Given the i...

    Authors: Kevin A. Murach, Sarah H. White, Yuan Wen, Angel Ho, Esther E. Dupont-Versteegden, John J. McCarthy and Charlotte A. Peterson

    Citation: Skeletal Muscle 2017 7:14

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  13. Content type: Research

    Facioscapulohumeral muscular dystrophy (FSHD) is most commonly inherited in an autosomal dominant pattern and caused by the abnormal expression of DUX4 in skeletal muscle. The DUX4 transcription factor has DNA...

    Authors: Premi Haynes, Kelly Kernan, Suk-Lin Zhou and Daniel G. Miller

    Citation: Skeletal Muscle 2017 7:13

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  14. Content type: Research

    Facioscapulohumeral muscular dystrophy (FSHD) is in most cases caused by a contraction of the D4Z4 macrosatellite repeat on chromosome 4 (FSHD1) or by mutations in the SMCHD1 or DNMT3B gene (FSHD2). Both situatio...

    Authors: Amanda G. Mason, Roderick C. Slieker, Judit Balog, Richard J. L. F. Lemmers, Chao-Jen Wong, Zizhen Yao, Jong-Won Lim, Galina N. Filippova, Enrico Ne, Rabi Tawil, Bas T. Heijmans, Stephen J. Tapscott and Silvère M. van der Maarel

    Citation: Skeletal Muscle 2017 7:12

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  15. Content type: Research

    Sarcospan (SSPN) is a transmembrane protein that interacts with the sarcoglycans (SGs) to form a tight subcomplex within the dystrophin-glycoprotein complex that spans the sarcolemma and interacts with laminin...

    Authors: Angela K. Peter, Gaynor Miller, Joana Capote, Marino DiFranco, Alhondra Solares-Pérez, Emily L. Wang, Jim Heighway, Ramón M. Coral-Vázquez, Julio Vergara and Rachelle H. Crosbie-Watson

    Citation: Skeletal Muscle 2017 7:11

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  16. Content type: Research

    The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through it...

    Authors: Haitao A. Wang, John D. Lee, Kah Meng Lee, Trent M. Woodruff and Peter G. Noakes

    Citation: Skeletal Muscle 2017 7:10

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  17. Content type: Research

    We previously reported that Wnt5a/CaMKIIδ (calcium/calmodulin-dependent protein kinase II delta) pathway was involved in the embryonic tongue deformity induced by excess retinoic acid (RA). Our latest study fo...

    Authors: Bo Liu, Chao Liu, Wei Cong, Nan Li, Nan Zhou, Yi Tang, Chao Wei, Han Bai, Ying Zhang and Jing Xiao

    Citation: Skeletal Muscle 2017 7:8

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  18. Content type: Research

    Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known t...

    Authors: Chehade Karam, Jianxun Yi, Yajuan Xiao, Kamal Dhakal, Lin Zhang, Xuejun Li, Carlo Manno, Jiejia Xu, Kaitao Li, Heping Cheng, Jianjie Ma and Jingsong Zhou

    Citation: Skeletal Muscle 2017 7:6

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  19. Content type: Research

    The spatial organization of eukaryotic genomes facilitates and reflects the underlying nuclear processes that are occurring in the cell. As such, the spatial organization of a genome represents a window on the...

    Authors: Malina D. Doynova, James F. Markworth, David Cameron-Smith, Mark H. Vickers and Justin M. O’Sullivan

    Citation: Skeletal Muscle 2017 7:5

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  20. Content type: Research

    The Ste20-like kinase, SLK, plays an important role in cell proliferation and cytoskeletal remodeling. In fibroblasts, SLK has been shown to respond to FAK/Src signaling and regulate focal adhesion turnover th...

    Authors: Benjamin R. Pryce, Khalid N. Al-Zahrani, Sébastien Dufresne, Natalya Belkina, Cédrik Labrèche, Genaro Patino-Lopez, Jérôme Frenette, Stephen Shaw and Luc A. Sabourin

    Citation: Skeletal Muscle 2017 7:3

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  21. Content type: Research

    There is much interest in the capacity of resistance exercise to prevent the age-related loss of skeletal muscle mass and function, known as sarcopenia. This study investigates the molecular basis underlying t...

    Authors: Zoe White, Jessica Terrill, Robert B. White, Christopher McMahon, Phillip Sheard, Miranda D. Grounds and Tea Shavlakadze

    Citation: Skeletal Muscle 2016 6:45

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    The Erratum to this article has been published in Skeletal Muscle 2017 7:4

  22. Content type: Research

    Large-scale expansion of myogenic progenitors is necessary to support the development of high-throughput cellular assays in vitro and to advance genetic engineering approaches necessary to develop cellular the...

    Authors: Christopher M. Penton, Vasudeo Badarinarayana, Joy Prisco, Elaine Powers, Mark Pincus, Ronald E. Allen and Paul R. August

    Citation: Skeletal Muscle 2016 6:44

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  23. Content type: Research

    hTERT/cdk4 immortalized myogenic human cell lines represent an important tool for skeletal muscle research, being used as therapeutically pertinent models of various neuromuscular disorders and in numerous fun...

    Authors: Matthew Thorley, Stéphanie Duguez, Emilia Maria Cristina Mazza, Sara Valsoni, Anne Bigot, Kamel Mamchaoui, Brennan Harmon, Thomas Voit, Vincent Mouly and William Duddy

    Citation: Skeletal Muscle 2016 6:43

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  24. Content type: Research

    Postnatal growth and repair of skeletal muscle relies upon a population of quiescent muscle precursor cells, called satellite cells that can be activated to proliferate and differentiate into new myofibers, as...

    Authors: Neena Lala-Tabbert, Hamood AlSudais, François Marchildon, Dechen Fu and Nadine Wiper-Bergeron

    Citation: Skeletal Muscle 2016 6:40

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  25. Content type: Research

    The myogenic capacity of satellite cells (SCs), adult muscle stem cells, is influenced by aging, exercise, and other factors. In skeletal muscle, the peroxisome proliferator-activated receptor γ coactivator 1α...

    Authors: Ivana Dinulovic, Regula Furrer, Markus Beer, Arnaud Ferry, Bettina Cardel and Christoph Handschin

    Citation: Skeletal Muscle 2016 6:39

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  26. Content type: Research

    Nuclear bodies, such as nucleoli, PML bodies, and SC35 speckles, are dynamic sub-nuclear structures that regulate multiple genetic and epigenetic processes. Additional regulation is provided by RNA/DNA handlin...

    Authors: Sachiko Homma, Mary Lou Beermann, Bryant Yu, Frederick M. Boyce and Jeffrey Boone Miller

    Citation: Skeletal Muscle 2016 6:42

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  27. Content type: Research

    Duchenne muscle dystrophy (DMD) is one of the most common lethal genetic diseases of children worldwide and is 100% fatal. Steroids, the only therapy currently available, are marred by poor efficacy and a high...

    Authors: Mun Chun Chan, Olivia Ziegler, Laura Liu, Glenn C. Rowe, Saumya Das, Leo E. Otterbein and Zoltan Arany

    Citation: Skeletal Muscle 2016 6:41

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  28. Content type: Research

    Skeletal muscle tissue has an enormous regenerative capacity that is instrumental for a successful defense against muscle injury and wasting. The peroxisome proliferator-activated receptor γ coactivator 1α (PG...

    Authors: Ivana Dinulovic, Regula Furrer, Sabrina Di Fulvio, Arnaud Ferry, Markus Beer and Christoph Handschin

    Citation: Skeletal Muscle 2016 6:38

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  29. Content type: Research

    Fluorescent-activated cell sorting (FACS) has enabled the direct isolation of highly enriched skeletal muscle stem cell, or satellite cell, populations from postnatal tissue. Several distinct surface marker pa...

    Authors: Claire C. Maesner, Albert E. Almada and Amy J. Wagers

    Citation: Skeletal Muscle 2016 6:35

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  30. Content type: Research

    Muscles of old animals are injured more easily and regenerate poorly, attributed in part to increased levels of circulating pro-inflammatory cytokines. The Janus kinase/signal transducers and activators of tra...

    Authors: Kristy Swiderski, Savant S. Thakur, Timur Naim, Jennifer Trieu, Annabel Chee, David I. Stapleton, René Koopman and Gordon S. Lynch

    Citation: Skeletal Muscle 2016 6:36

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  31. Content type: Research

    Cholinergic dysfunction occurs during aging and in a variety of diseases, including amyotrophic lateral sclerosis (ALS). However, it remains unknown whether changes in cholinergic transmission contributes to a...

    Authors: Satoshi Sugita, Leland L. Fleming, Caleb Wood, Sydney K. Vaughan, Matheus P. S. M. Gomes, Wallace Camargo, Ligia A. Naves, Vania F. Prado, Marco A. M. Prado, Cristina Guatimosim and Gregorio Valdez

    Citation: Skeletal Muscle 2016 6:31

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  32. Content type: Research

    The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan express...

    Authors: Addolorata Pisconti, Glen B. Banks, Farshad Babaeijandaghi, Nicole Dalla Betta, Fabio M. V. Rossi, Jeffrey S. Chamberlain and Bradley B. Olwin

    Citation: Skeletal Muscle 2016 6:34

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  33. Content type: Methodology

    Cellular models of muscle disease are taking on increasing importance with the large number of genes and mutations implicated in causing myopathies and the concomitant need to test personalized therapies. Deve...

    Authors: Ellis Y. Kim, Patrick Page, Lisa M. Dellefave-Castillo, Elizabeth M. McNally and Eugene J. Wyatt

    Citation: Skeletal Muscle 2016 6:32

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  34. Content type: Research

    Adult skeletal muscles are composed of slow and fast myofiber subtypes which each express selective genes required for their specific contractile and metabolic activity. Six homeoproteins are transcription fac...

    Authors: Iori Sakakibara, Maud Wurmser, Matthieu Dos Santos, Marc Santolini, Serge Ducommun, Romain Davaze, Anthony Guernec, Kei Sakamoto and Pascal Maire

    Citation: Skeletal Muscle 2016 6:30

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  35. Content type: Research

    Skeletal muscle displays a marked accumulation of denervated myofibers at advanced age, which coincides with an acceleration of muscle atrophy.

    Authors: Sudhakar Aare, Sally Spendiff, Madhusudanarao Vuda, Daren Elkrief, Anna Perez, Qinghua Wu, Dominique Mayaki, Sabah N. A. Hussain, Stefan Hettwer and Russell T. Hepple

    Citation: Skeletal Muscle 2016 6:29

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  36. Content type: Research

    Master transcription factor MyoD can initiate the entire myogenic gene expression program which differentiates proliferating myoblasts into multinucleated myotubes. We previously demonstrated that histone meth...

    Authors: Biswanath Chatterjee, David W. Wolff, Mathivanan Jothi, Munmun Mal and Asoke K. Mal

    Citation: Skeletal Muscle 2016 6:28

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  37. Content type: Research

    Cachexia affects the majority of patients with advanced cancer and is associated with reduced treatment tolerance, response to therapy, quality of life, and life expectancy. Cachectic patients with advanced ca...

    Authors: Shinji Hatakeyama, Serge Summermatter, Marie Jourdain, Stefan Melly, Giulia C. Minetti and Estelle Lach-Trifilieff

    Citation: Skeletal Muscle 2016 6:26

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  38. Content type: Research

    The greater susceptibility to contraction-induced skeletal muscle injury (fragility) is an important dystrophic feature and tool for testing preclinic dystrophin-based therapies for Duchenne muscular dystrophy...

    Authors: Pauline Roy, Fredérique Rau, Julien Ochala, Julien Messéant, Bodvael Fraysse, Jeanne Lainé, Onnik Agbulut, Gillian Butler-Browne, Denis Furling and Arnaud Ferry

    Citation: Skeletal Muscle 2016 6:23

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  39. Content type: Methodology

    Dystrophin is a rod-shaped cytoplasmic protein that provides sarcolemmal stability as a structural link between the cytoskeleton and the extracellular matrix via the dystrophin-associated protein complex (DAPC...

    Authors: Mina V. Petkova, Susanne Morales-Gonzales, Karima Relizani, Esther Gill, Franziska Seifert, Josefine Radke, Werner Stenzel, Luis Garcia, Helge Amthor and Markus Schuelke

    Citation: Skeletal Muscle 2016 6:25

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  40. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that is typically fatal within 3–5 years of diagnosis. While motoneuron death is the defining characteristic of ALS, the events ...

    Authors: Donald Beqollari, Christin F. Romberg, Gabriella Dobrowolny, Martina Martini, Andrew A. Voss, Antonio Musarò and Roger A. Bannister

    Citation: Skeletal Muscle 2016 6:24

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