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  1. Human skeletal muscle is composed of three major fiber types, referred to as type 1, 2A, and 2X fibers. This heterogeneous cellular composition complicates the interpretation of studies based on whole skeletal...

    Authors: Marta Murgia, Leonardo Nogara, Martina Baraldo, Carlo Reggiani, Matthias Mann and Stefano Schiaffino
    Citation: Skeletal Muscle 2021 11:24
  2. CRISPR/Cas9 is an invaluable tool for studying cell biology and the development of molecular therapies. However, delivery of CRISPR/Cas9 components into some cell types remains a major hurdle. Primary human my...

    Authors: Hayley Goullée, Rhonda L. Taylor, Alistair R. R. Forrest, Nigel G. Laing, Gianina Ravenscroft and Joshua S. Clayton
    Citation: Skeletal Muscle 2021 11:23
  3. Although muscle regenerative capacity declines with age, the extent to which this is due to satellite cell-intrinsic changes vs. environmental changes has been controversial. The majority of aging studies have...

    Authors: Robert W. Arpke, Ahmed S. Shams, Brittany C. Collins, Alexie A. Larson, Nguyen Lu, Dawn A. Lowe and Michael Kyba
    Citation: Skeletal Muscle 2021 11:22
  4. Duchenne muscular dystrophy (DMD) is an incurable disease, caused by the mutations in the DMD gene, encoding dystrophin, an actin-binding cytoskeletal protein. Lack of functional dystrophin results in muscle weak...

    Authors: Olga Mucha, Paulina Podkalicka, Katarzyna Kaziród, Emilia Samborowska, Józef Dulak and Agnieszka Łoboda
    Citation: Skeletal Muscle 2021 11:21
  5. Caenorhabditis elegans has been widely used as a model to study muscle structure and function. Its body wall muscle is functionally and structurally similar to vertebrate skeletal muscle with conserved molecular ...

    Authors: Leila Lesanpezeshki, Hiroshi Qadota, Masoud Norouzi Darabad, Karishma Kashyap, Carla M. R. Lacerda, Nathaniel J. Szewczyk, Guy M. Benian and Siva A. Vanapalli
    Citation: Skeletal Muscle 2021 11:20
  6. In the search of genetic determinants of Duchenne muscular dystrophy (DMD) severity, LTBP4, a member of the latent TGF-β binding protein family, emerged as an important predictor of functional outcome trajectorie...

    Authors: Simonetta Andrea Licandro, Luca Crippa, Roberta Pomarico, Raffaella Perego, Gianluca Fossati, Flavio Leoni and Christian Steinkühler
    Citation: Skeletal Muscle 2021 11:19
  7. During skeletal muscle regeneration, satellite stem cells use distinct pathways to repair damaged myofibers or to self-renew by returning to quiescence. Cellular/mitotic quiescence employs mechanisms that prom...

    Authors: Nainita Roy, Swetha Sundar, Malini Pillai, Farah Patell-Socha, Sravya Ganesh, Ajoy Aloysius, Mohammed Rumman, Hardik Gala, Simon M. Hughes, Peter S. Zammit and Jyotsna Dhawan
    Citation: Skeletal Muscle 2021 11:18
  8. Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments. This long-term process could be shortened by the drug-r...

    Authors: Lin Zhou, Tong Zhang, Wei Shao, Ruohan Lu, Lin Wang, Haisheng Liu, Bin Jiang, Shiqin Li, Huiqin Zhuo, Suheng Wang, Qinxi Li, Caihua Huang and Donghai Lin
    Citation: Skeletal Muscle 2021 11:17
  9. Striated muscle is a highly plastic and regenerative organ that regulates body movement, temperature, and metabolism—all the functions needed for an individual’s health and well-being. The muscle connective ti...

    Authors: Osvaldo Contreras, Fabio M. V. Rossi and Marine Theret
    Citation: Skeletal Muscle 2021 11:16
  10. Diabetes-related muscle wasting is one of the devastating complications of diabetes, which is associated with muscle autophagy due to insulin-mediated glucose starvation. However, treatment for diabetes-relate...

    Authors: Yuchun Cai, Hongyue Zhan, Wenci Weng, Yao Wang, Pengxun Han, Xuewen Yu, Mumin Shao and Huili Sun
    Citation: Skeletal Muscle 2021 11:15
  11. The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4). Because IL-4 is an esse...

    Authors: Mitsutoshi Kurosaka, Yuji Ogura, Shuichi Sato, Kazuhisa Kohda and Toshiya Funabashi
    Citation: Skeletal Muscle 2021 11:14
  12. Skeletal muscle myofibers can be separated into functionally distinct cell types that differ in gene and protein expression. Current single cell expression data is generally based upon single nucleus RNA, rath...

    Authors: Rohan X. Verma, Suraj Kannan, Brian L. Lin, Katherine M. Fomchenko, Tim O. Nieuwenhuis, Arun H. Patil, Clarisse Lukban, Xiaoping Yang, Karen Fox-Talbot, Matthew N. McCall, Chulan Kwon, David A. Kass, Avi Z. Rosenberg and Marc K. Halushka
    Citation: Skeletal Muscle 2021 11:13
  13. In vitro maturation of human primary myoblasts using 2D culture remains a challenging process and leads to immature fibers with poor internal organization and function. This would however represent a valuable sys...

    Authors: Jessica Brunetti, Stéphane Koenig, Arthur Monnier and Maud Frieden
    Citation: Skeletal Muscle 2021 11:12
  14. Old age is associated with a significantly increased mortality in COVID-19 patients exposed to long-term controlled mechanical ventilation (CMV) and suggested to be due to the hyperinflammatory response associ...

    Authors: Qiong Lyu, Ya Wen, Xiang Zhang, Alex B. Addinsall, Nicola Cacciani and Lars Larsson
    Citation: Skeletal Muscle 2021 11:11
  15. ALAS2 (delta-aminolevulinate synthase 2) is one of the two isoenzymes catalyzing the synthesis of delta-aminolevulinic acid (ALA), which is the first precursor of heme synthesis. ALAS2-overexpressing transgeni...

    Authors: Yahui Peng, Jihong Li, Dixian Luo, Shuai Zhang, Sijia Li, Dayong Wang, Xidi Wang, Zhujun Zhang, Xue Wang, Changhui Sun, Xu Gao, Yang Hui and Rongzhang He
    Citation: Skeletal Muscle 2021 11:9
  16. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Adeel Safdar, Konstantin Khrapko, James M. Flynn, Ayesha Saleem, Michael De Lisio, Adam P. W. Johnston, Yevgenya Kratysberg, Imtiaz A. Samjoo, Yu Kitaoka, Daniel I. Ogborn, Jonathan P. Little, Sandeep Raha, Gianni Parise, Mahmood Akhtar, Bart P. Hettinga, Glenn C. Rowe…
    Citation: Skeletal Muscle 2021 11:8

    The original article was published in Skeletal Muscle 2016 6:7

  17. Satellite cells (SCs) are muscle stem cells capable of regenerating injured muscle. The study of their functional potential depends on the availability of methods for the isolation and expansion of pure SCs wi...

    Authors: Anna Benedetti, Gianluca Cera, Daniele De Meo, Ciro Villani, Marina Bouche and Biliana Lozanoska-Ochser
    Citation: Skeletal Muscle 2021 11:7
  18. Sarcopenia is a common skeletal disease related to myogenic disorders and muscle atrophy. Current clinical management has limited effectiveness. We sought to investigate the role of miR-1290 in myoblast differ...

    Authors: Ji Che, Cuidi Xu, Yuanyuan Wu, Peiyu Jia, Qi Han, Yantao Ma, Xiaolei Wang and Yongjun Zheng
    Citation: Skeletal Muscle 2021 11:6
  19. Myogenin is a transcription factor that is expressed during terminal myoblast differentiation in embryonic development and adult muscle regeneration. Investigation of this cell state transition has been hampered ...

    Authors: Maria Benavente-Diaz, Glenda Comai, Daniela Di Girolamo, Francina Langa and Shahragim Tajbakhsh
    Citation: Skeletal Muscle 2021 11:5
  20. Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this i...

    Authors: Stephan Kröger and Bridgette Watkins
    Citation: Skeletal Muscle 2021 11:3
  21. A cohort of related miniature dachshund dogs with exercise intolerance, stiff gait, dysphagia, myoglobinuria, and markedly elevated serum creatine kinase activities were identified.

    Authors: James R. Mickelson, Katie M. Minor, Ling T. Guo, Steven G. Friedenberg, Jonah N. Cullen, Amanda Ciavarella, Lydia E. Hambrook, Karen M. Brenner, Sarah E. Helmond, Stanley L. Marks and G. Diane Shelton
    Citation: Skeletal Muscle 2021 11:2
  22. Nonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, ...

    Authors: Vanessa E. Jahnke, Jennifer M. Peterson, Jack H. Van Der Meulen, Jessica Boehler, Kitipong Uaesoontrachoon, Helen K. Johnston, Aurelia Defour, Aditi Phadke, Qing Yu, Jyoti K. Jaiswal and Kanneboyina Nagaraju
    Citation: Skeletal Muscle 2020 10:37
  23. The nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as a master cytoprotective factor regulating the expression of genes encoding anti-oxidant, anti-inflammatory, and detoxifying proteins. The...

    Authors: Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Paulina Podkalicka, Neli Kachamakova-Trojanowska, Agnieszka Łoboda and Józef Dulak
    Citation: Skeletal Muscle 2020 10:35
  24. Tetraspanins are a family of proteins known to assemble protein complexes at the cell membrane. They are thought to play diverse cellular functions in tissues by modifying protein-binding partners, thus bringi...

    Authors: Arielle Hall, Tatiana Fontelonga, Alec Wright, Katlynn Bugda Gwilt, Jeffrey Widrick, Alessandra Pasut, Francesco Villa, Cynthia K. Miranti, Devin Gibbs, Evan Jiang, Hui Meng, Michael W. Lawlor and Emanuela Gussoni
    Citation: Skeletal Muscle 2020 10:34
  25. The RYR1 gene, which encodes the sarcoplasmic reticulum calcium release channel or type 1 ryanodine receptor (RyR1) of skeletal muscle, was sequenced in 1988 and RYR1 variations that impair calcium homeostasis an...

    Authors: Tokunbor A. Lawal, Joshua J. Todd, Jessica W. Witherspoon, Carsten G. Bönnemann, James J. Dowling, Susan L. Hamilton, Katherine G. Meilleur and Robert T. Dirksen
    Citation: Skeletal Muscle 2020 10:32
  26. Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain la...

    Authors: David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin and H. Fritz Kramer
    Citation: Skeletal Muscle 2020 10:30
  27. Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder and is one of the most common muscular dystrophies. There are currently few effective therapies to treat the disease, although many small-mo...

    Authors: Gist H. Farr III, Melanie Morris, Arianna Gomez, Thao Pham, Elisabeth Kilroy, Elizabeth U. Parker, Shery Said, Clarissa Henry and Lisa Maves
    Citation: Skeletal Muscle 2020 10:29
  28. Satellite cells are the canonical muscle stem cells that regenerate damaged skeletal muscle. Loss of function of these cells has been linked to reduced muscle repair capacity and compromised muscle health in a...

    Authors: Sean M. Buchanan, Feodor D. Price, Alessandra Castiglioni, Amanda Wagner Gee, Joel Schneider, Mark N. Matyas, Monica Hayhurst, Mohammadsharif Tabebordbar, Amy J. Wagers and Lee L. Rubin
    Citation: Skeletal Muscle 2020 10:28
  29. Facioscapulohumeral muscular dystrophy (FSHD) is a skeletal muscle disorder that is caused by derepression of the transcription factor DUX4 in skeletal muscle cells. Apart from SMCHD1, DNMT3B was recently iden...

    Authors: Linde F. Bouwman, Bianca den Hamer, Elwin P. Verveer, Lente J. S. Lerink, Yvonne D. Krom, Silvère M. van der Maarel and Jessica C. de Greef
    Citation: Skeletal Muscle 2020 10:27
  30. Duchenne muscular dystrophy (DMD) is a degenerative muscle disease caused by mutations in the dystrophin gene. Loss of dystrophin prevents the formation of a critical connection between the muscle cell membran...

    Authors: Cynthia Shu, Liubov Parfenova, Ekaterina Mokhonova, Judd R. Collado, Robert Damoiseaux, Jesus Campagna, Varghese John and Rachelle H. Crosbie
    Citation: Skeletal Muscle 2020 10:26
  31. Elderly populations are susceptible to critical limb ischemia (CLI), but conventional treatments cannot significantly decrease amputation and mortality. Although exercise is an effective “non-pharmacological m...

    Authors: Wuyang He, Peng Wang, Qingwei Chen and Chunqiu Li
    Citation: Skeletal Muscle 2020 10:25
  32. Distal arthrogryposis (DA) is a group of autosomal dominant skeletal muscle diseases characterized by congenital contractures of distal limb joints. The most common cause of DA is a mutation of the embryonic m...

    Authors: Yiming Guo, William A. Kronert, Karen H. Hsu, Alice Huang, Floyd Sarsoza, Kaylyn M. Bell, Jennifer A. Suggs, Douglas M. Swank and Sanford I. Bernstein
    Citation: Skeletal Muscle 2020 10:24
  33. Canine models of Duchenne muscular dystrophy (DMD) are a valuable tool to evaluate potential therapies because they faithfully reproduce the human disease. Several cases of dystrophinopathies have been describ...

    Authors: Inès Barthélémy, Nadège Calmels, Robert B. Weiss, Laurent Tiret, Adeline Vulin, Nicolas Wein, Cécile Peccate, Carole Drougard, Christophe Beroud, Nathalie Deburgrave, Jean-Laurent Thibaud, Catherine Escriou, Isabel Punzón, Luis Garcia, Jean-Claude Kaplan, Kevin M. Flanigan…
    Citation: Skeletal Muscle 2020 10:23
  34. Satellite cells (SCs) are required for muscle repair following injury and are involved in muscle remodeling upon muscular contractions. Exercise stimulates SC accumulation and myonuclear accretion. To what ext...

    Authors: Evi Masschelein, Gommaar D’Hulst, Joel Zvick, Laura Hinte, Inés Soro-Arnaiz, Tatiane Gorski, Ferdinand von Meyenn, Ori Bar-Nur and Katrien De Bock
    Citation: Skeletal Muscle 2020 10:21
  35. Skeletal muscle is increasingly considered an endocrine organ secreting myokines and extracellular vesicles (exosomes and microvesicles), which can affect physiological changes with an impact on different path...

    Authors: Laura Le Gall, Zamalou Gisele Ouandaogo, Ekene Anakor, Owen Connolly, Gillian Butler Browne, Jeanne Laine, William Duddy and Stephanie Duguez
    Citation: Skeletal Muscle 2020 10:20
  36. Single-cell RNA-sequencing (scRNA-seq) facilitates the unbiased reconstruction of multicellular tissue systems in health and disease. Here, we present a curated scRNA-seq dataset of human muscle samples from 1...

    Authors: Andrea J. De Micheli, Jason A. Spector, Olivier Elemento and Benjamin D. Cosgrove
    Citation: Skeletal Muscle 2020 10:19
  37. Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result in progressive muscle wasting and inflammation leadin...

    Authors: Pamela Barraza-Flores, Hailey J. Hermann, Christina R. Bates, Tyler G. Allen, Timothy T. Grunert and Dean J. Burkin
    Citation: Skeletal Muscle 2020 10:18
  38. Skeletal muscle function is essential for health, and it depends on the proper activity of myofibers and their innervating motor neurons. Each adult muscle is composed of different types of myofibers with dist...

    Authors: Tania Incitti, Alessandro Magli, Asher Jenkins, Karena Lin, Ami Yamamoto and Rita C. R. Perlingeiro
    Citation: Skeletal Muscle 2020 10:17
  39. Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by loss of alpha motor neurons and skeletal muscle atrophy. The disease is caused by mutations of the SMN1 gene that result in reduced fu...

    Authors: Guzal Khayrullina, Kasey E. Moritz, James F. Schooley, Naheed Fatima, Coralie Viollet, Nikki M. McCormack, Jeremy T. Smyth, Martin L. Doughty, Clifton L. Dalgard, Thomas P. Flagg and Barrington G. Burnett
    Citation: Skeletal Muscle 2020 10:16
  40. The arrangement of myonuclei in skeletal muscle tissue has long been used as a biomarker for muscle health, but there is a dearth of in vivo exploration of potential effects of myonuclear organization on the f...

    Authors: Robert Louis Hastings, Ryan T. Massopust, Seth G. Haddix, Young il Lee and Wesley J. Thompson
    Citation: Skeletal Muscle 2020 10:15
  41. PGC-1 (peroxisome-proliferator-activated receptor-γ coactivator-1) alpha is a potent transcriptional coactivator that coordinates the activation of numerous metabolic processes. Exercise strongly induces PGC-1...

    Authors: Steven Yang, Emanuele Loro, Shogo Wada, Boa Kim, Wei-Ju Tseng, Kristina Li, Tejvir S. Khurana and Zoltan Arany
    Citation: Skeletal Muscle 2020 10:14
  42. In Duchenne muscular dystrophy (DMD), DYSTROPHIN deficiency exposes myofibers to repeated cycles of contraction/degeneration, ultimately leading to muscle loss and replacement by fibrotic tissue. DMD pathology...

    Authors: Luca Caputo, Alice Granados, Jessica Lenzi, Alessandro Rosa, Slimane Ait-Si-Ali, Pier Lorenzo Puri and Sonia Albini
    Citation: Skeletal Muscle 2020 10:13
  43. Pulmonary hypertension leads to right ventricular heart failure and ultimately to cardiac cachexia. Cardiac cachexia induces skeletal muscles atrophy and contractile dysfunction. MAFbx and MuRF1 are two key pr...

    Authors: Thanh Nguyen, T. Scott Bowen, Antje Augstein, Antje Schauer, Alexander Gasch, Axel Linke, Siegfried Labeit and Volker Adams
    Citation: Skeletal Muscle 2020 10:12

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