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Research
Muscles of old animals are injured more easily and regenerate poorly, attributed in part to increased levels of circulating pro-inflammatory cytokines. The Janus kinase/signal transducers and activators of tra...
Skeletal Muscle 2016 6:36
Published on: 24 October 2016
Review
The circadian oscillations of muscle genes are controlled either directly by the intrinsic muscle clock or by extrinsic factors, such as feeding, hormonal signals, or neural influences, which are in turn regul...
Skeletal Muscle 2016 6:33
Published on: 13 October 2016
Research
Cholinergic dysfunction occurs during aging and in a variety of diseases, including amyotrophic lateral sclerosis (ALS). However, it remains unknown whether changes in cholinergic transmission contributes to a...
Skeletal Muscle 2016 6:31
Published on: 5 October 2016
Research
The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan express...
Skeletal Muscle 2016 6:34
Published on: 4 October 2016
Methodology
Cellular models of muscle disease are taking on increasing importance with the large number of genes and mutations implicated in causing myopathies and the concomitant need to test personalized therapies. Deve...
Skeletal Muscle 2016 6:32
Published on: 15 September 2016
Research
Adult skeletal muscles are composed of slow and fast myofiber subtypes which each express selective genes required for their specific contractile and metabolic activity. Six homeoproteins are transcription fac...
Skeletal Muscle 2016 6:30
Published on: 5 September 2016
Research
Skeletal muscle displays a marked accumulation of denervated myofibers at advanced age, which coincides with an acceleration of muscle atrophy.
Skeletal Muscle 2016 6:29
Published on: 1 September 2016
Research
Master transcription factor MyoD can initiate the entire myogenic gene expression program which differentiates proliferating myoblasts into multinucleated myotubes. We previously demonstrated that histone meth...
Skeletal Muscle 2016 6:28
Published on: 22 August 2016
Review
The esophagus functions to transport food from the oropharyngeal region to the stomach via waves of peristalsis and transient relaxation of the lower esophageal sphincter. The gastrointestinal tract, including...
Skeletal Muscle 2016 6:27
Published on: 8 August 2016
Research
Cachexia affects the majority of patients with advanced cancer and is associated with reduced treatment tolerance, response to therapy, quality of life, and life expectancy. Cachectic patients with advanced ca...
Skeletal Muscle 2016 6:26
Published on: 26 July 2016
Research
The greater susceptibility to contraction-induced skeletal muscle injury (fragility) is an important dystrophic feature and tool for testing preclinic dystrophin-based therapies for Duchenne muscular dystrophy...
Skeletal Muscle 2016 6:23
Published on: 20 July 2016
Methodology
Dystrophin is a rod-shaped cytoplasmic protein that provides sarcolemmal stability as a structural link between the cytoskeleton and the extracellular matrix via the dystrophin-associated protein complex (DAPC...
Skeletal Muscle 2016 6:25
Published on: 5 July 2016
Research
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that is typically fatal within 3–5 years of diagnosis. While motoneuron death is the defining characteristic of ALS, the events ...
Skeletal Muscle 2016 6:24
Published on: 23 June 2016
Research
Duchenne muscular dystrophy (DMD) is an inherited lethal muscle wasting disease characterized by cycles of degeneration and regeneration, with no effective therapy. Growth differentiation factor 11 (GDF11), a ...
Skeletal Muscle 2016 6:21
Published on: 14 June 2016
Research
Secondary dystroglycanopathies are a subset of muscular dystrophy caused by abnormal glycosylation of α-dystroglycan (αDG). Loss of αDG functional glycosylation prevents it from binding to laminin and other ex...
Skeletal Muscle 2016 6:20
Published on: 2 June 2016
Research
Euchromatic histone-lysine N-methyltransferase 2 (G9a/Ehmt2) is the main enzyme responsible for the apposition of H3K9 di-methylation on histones. Due to its dual role as an epigenetic regulator and in the regula...
Skeletal Muscle 2016 6:22
Published on: 27 May 2016
Erratum
Skeletal Muscle 2016 6:19
Published on: 4 May 2016
The original article was published in Skeletal Muscle 2016 6:16
Research
Remodeling of the extracellular matrix (ECM) regulates cell adhesion as well as signaling between cells and their microenvironment. Despite the importance of tightly regulated ECM remodeling for normal muscle ...
Skeletal Muscle 2016 6:18
Published on: 2 May 2016
Research
The SH3 and cysteine-rich domain 3 (Stac3) gene is specifically expressed in the skeletal muscle. Stac3 knockout mice die perinatally. In this study, we determined the potential role of Stac3 in postnatal skeleta...
Skeletal Muscle 2016 6:17
Published on: 11 April 2016
Research
Electrical activity regulates the expression of skeletal muscle genes by a process known as “excitation-transcription” (E-T) coupling. We have demonstrated that release of adenosine 5′-triphosphate (ATP) durin...
Skeletal Muscle 2016 6:15
Published on: 11 April 2016
Review
Muscle atrophy derived from excessive proteolysis is a hallmark of numerous disease conditions. Accordingly, the negative consequences of skeletal muscle protein breakdown often overshadow the critical nature ...
Skeletal Muscle 2016 6:16
Published on: 6 April 2016
The Erratum to this article has been published in Skeletal Muscle 2016 6:19
Research
Myostatin (Mstn) is a negative regulator of muscle growth whose inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in which myostatin is knocked out or inhibited postnatally have a ...
Skeletal Muscle 2016 6:14
Published on: 4 April 2016
Research
Diabetes is the seventh leading cause of death in the USA, and disruption of circadian rhythms is gaining recognition as a contributing factor to disease prevalence. This disease is characterized by hyperglyce...
Skeletal Muscle 2016 6:12
Published on: 30 March 2016
Research
The mammalian target of rapamycin complex 1 (mTORC1) is a central node in a network of signaling pathways controlling cell growth and survival. This multiprotein complex integrates external signals and affects...
Skeletal Muscle 2016 6:13
Published on: 21 March 2016
Research
Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although or...
Skeletal Muscle 2016 6:9
Published on: 15 March 2016
