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  1. Content type: Research

    The mammalian target of rapamycin complex 1 (mTORC1) is a central node in a network of signaling pathways controlling cell growth and survival. This multiprotein complex integrates external signals and affects...

    Authors: Maitea Guridi, Barbara Kupr, Klaas Romanino, Shuo Lin, Denis Falcetta, Lionel Tintignac and Markus A. Rüegg

    Citation: Skeletal Muscle 2016 6:13

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  2. Content type: Research

    Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although or...

    Authors: Jessica Segalés, Abul B. M. M. K. Islam, Roshan Kumar, Qi-Cai Liu, Pedro Sousa-Victor, F. Jeffrey Dilworth, Esteban Ballestar, Eusebio Perdiguero and Pura Muñoz-Cánoves

    Citation: Skeletal Muscle 2016 6:9

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  3. Content type: Research

    Hypoxia exposure is known to induce an alteration in skeletal muscle fiber-type distribution mediated by hypoxia-inducible factor (HIF)-α. The downstream pathway of HIF-α leading to fiber-type shift, however, ...

    Authors: Junchul Shin, Aki Nunomiya, Yasuo Kitajima, Takashi Dan, Toshio Miyata and Ryoichi Nagatomi

    Citation: Skeletal Muscle 2016 6:5

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  4. Content type: Methodology

    Studies of the pathogenic mechanisms underlying human myopathies and muscular dystrophies often require animal models, but models of some human diseases are not yet available. Methods to promote the engraftmen...

    Authors: Paraskevi Sakellariou, Andrea O’Neill, Amber L. Mueller, Guido Stadler, Woodring E. Wright, Joseph A. Roche and Robert J. Bloch

    Citation: Skeletal Muscle 2016 6:4

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  5. Content type: Research

    The defective glycosylation of α-dystroglycan is associated with a group of muscular dystrophies that are collectively referred to as the secondary dystroglycanopathies. Mutations in the gene encoding fukutin-...

    Authors: Jihee Kim, Mark Hopkinson, Manoli Kavishwar, Marta Fernandez-Fuente and Susan Carol Brown

    Citation: Skeletal Muscle 2016 6:3

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  6. Content type: Research

    Low mitochondrial content and oxidative capacity are well-established features of locomotor muscle dysfunction, a prevalent and debilitating systemic occurrence in patients with chronic obstructive pulmonary d...

    Authors: Yana Konokhova, Sally Spendiff, R. Thomas Jagoe, Sudhakar Aare, Sophia Kapchinsky, Norah J. MacMillan, Paul Rozakis, Martin Picard, Mylène Aubertin-Leheudre, Charlotte H. Pion, Jean Bourbeau, Russell T. Hepple and Tanja Taivassalo

    Citation: Skeletal Muscle 2016 6:10

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  7. Content type: Methodology

    Most cultured enzymatically dissociated adult myofibers exhibit spatially uniform (UNI) contractile responses and Ca2+ transients over the entire myofiber in response to electric field stimuli of either polarity ...

    Authors: Erick O. Hernández-Ochoa, Camilo Vanegas, Shama R. Iyer, Richard M. Lovering and Martin F. Schneider

    Citation: Skeletal Muscle 2016 6:6

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  8. Content type: Research

    Human genetic disorders and transgenic mouse models have shown that mitochondrial DNA (mtDNA) mutations and telomere dysfunction instigate the aging process. Epidemiologically, exercise is associated with grea...

    Authors: Adeel Safdar, Konstantin Khrapko, James M. Flynn, Ayesha Saleem, Michael De Lisio, Adam P. W. Johnston, Yevgenya Kratysberg, Imtiaz A. Samjoo, Yu Kitaoka, Daniel I. Ogborn, Jonathan P. Little, Sandeep Raha, Gianni Parise, Mahmood Akhtar, Bart P. Hettinga, Glenn C. Rowe…

    Citation: Skeletal Muscle 2016 6:7

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  9. Content type: Research

    Misexpression of the double homeodomain transcription factor DUX4 results in facioscapulohumeral muscular dystrophy (FSHD). A DNA-binding consensus with two tandem TAAT motifs based on chromatin IP peaks has b...

    Authors: Yu Zhang, John K. Lee, Erik A. Toso, Joslynn S. Lee, Si Ho Choi, Matthew Slattery, Hideki Aihara and Michael Kyba

    Citation: Skeletal Muscle 2016 6:8

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  10. Content type: Research

    Abnormal branched myofibers within skeletal muscles are commonly found in diverse animal models of muscular dystrophy as well as in patients. Branched myofibers from dystrophic mice are more susceptible to bre...

    Authors: Christophe Pichavant, Thomas J. Burkholder and Grace K. Pavlath

    Citation: Skeletal Muscle 2016 6:2

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  11. Content type: Review

    Skeletal muscle has a remarkable capacity to regenerate by virtue of its resident stem cells (satellite cells). This capacity declines with aging, although whether this is due to extrinsic changes in the envir...

    Authors: Andrew S. Brack and Pura Muñoz-Cánoves

    Citation: Skeletal Muscle 2016 6:1

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  12. Content type: Research

    Anoctamin 5 (ANO5) is a member of a conserved gene family (TMEM16), which codes for proteins predicted to have eight transmembrane domains and putative Ca2+-activated chloride channel (CaCC) activity. It was rece...

    Authors: Jing Xu, Mona El Refaey, Li Xu, Lixia Zhao, Yandi Gao, Kyle Floyd, Tallib Karaze, Paul M. L. Janssen and Renzhi Han

    Citation: Skeletal Muscle 2015 5:43

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  13. Content type: Research

    Adult skeletal muscle adapts to functional needs, maintaining consistent numbers of myonuclei and stem cells. Although resident muscle stem cells or satellite cells are required for muscle growth and repair, i...

    Authors: Bradley Pawlikowski, Crystal Pulliam, Nicole Dalla Betta, Gabrielle Kardon and Bradley B. Olwin

    Citation: Skeletal Muscle 2015 5:42

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  14. Content type: Research

    Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene. The immune inflammatory response also contributes to disease progression in DMD patients. In a previous study, we demonstrated h...

    Authors: Fernanda Pinto-Mariz, Luciana Rodrigues Carvalho, Alexandra Prufer De Queiroz Campos Araujo, Wallace De Mello, Márcia Gonçalves Ribeiro, Maria Do Carmo Soares Alves Cunha, Pedro Hernan Cabello, Ingo Riederer, Elisa Negroni, Isabelle Desguerre, Mariana Veras, Erica Yada, Yves Allenbach, Olivier Benveniste, Thomas Voit, Vincent Mouly…

    Citation: Skeletal Muscle 2015 5:45

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  15. Content type: Research

    Obese adults are prone to develop metabolic and cardiovascular diseases. Furthermore, over-weight expectant mothers give birth to large babies who also have increased likelihood of developing metabolic and car...

    Authors: Antonios Matsakas, Domenick A. Prosdocimo, Robert Mitchell, Henry Collins-Hooper, Natasa Giallourou, Jonathan R. Swann, Paul Potter, Thomas Epting, Mukesh K. Jain and Ketan Patel

    Citation: Skeletal Muscle 2015 5:38

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  16. Content type: Research

    The mammalian esophageal musculature is unique in that it makes a transition from smooth to skeletal muscle, with most of this process occurring after birth. In order to better understand the mechanisms that c...

    Authors: Daisuke Chihara, Anthony I. Romer, C. Florian Bentzinger, Michael A. Rudnicki and Robert S. Krauss

    Citation: Skeletal Muscle 2015 5:39

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  17. Content type: Research

    Systemic delivery of anti-sense oligonucleotides to Duchenne muscular dystrophy (DMD) patients to induce de novo dystrophin protein expression in muscle (exon skipping) is a promising therapy. Treatment with P...

    Authors: Maria Candida Vila, Margaret Benny Klimek, James S. Novak, Sree Rayavarapu, Kitipong Uaesoontrachoon, Jessica F. Boehler, Alyson A. Fiorillo, Marshall W. Hogarth, Aiping Zhang, Conner Shaughnessy, Heather Gordish-Dressman, Umar Burki, Volker Straub, Qi Long Lu, Terence A. Partridge, Kristy J. Brown…

    Citation: Skeletal Muscle 2015 5:44

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  18. Content type: Research

    Satellite cells, or muscle stem cells, have been thought to be responsible for all muscle plasticity, but recent studies using genetically modified mouse models that allow for the conditional ablation of satel...

    Authors: Janna R. Jackson, Tyler J. Kirby, Christopher S. Fry, Robin L. Cooper, John J. McCarthy, Charlotte A. Peterson and Esther E. Dupont-Versteegden

    Citation: Skeletal Muscle 2015 5:41

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  19. Content type: Research

    Duchenne muscular dystrophy (DMD) is a devastating X-linked recessive genetic myopathy. DMD physiopathology is still not fully understood and a prenatal onset is suspected but difficult to address.

    Authors: Emmanuelle Massouridès, Jérôme Polentes, Philippe-Emmanuel Mangeot, Virginie Mournetas, Juliette Nectoux, Nathalie Deburgrave, Patrick Nusbaum, France Leturcq, Linda Popplewell, George Dickson, Nicolas Wein, Kevin M. Flanigan, Marc Peschanski, Jamel Chelly and Christian Pinset

    Citation: Skeletal Muscle 2015 5:40

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  20. Content type: Research

    Gene therapy strategies are promising therapeutic options for monogenic muscular dystrophies, with several currently underways. The adeno-associated viral (AAV) vector is among the most effective gene delivery...

    Authors: Muhammad Riaz, Yotam Raz, Elizabeth B. Moloney, Maaike van Putten, Yvonne D. Krom, Silvere M. van der Maarel, Joost Verhaagen and Vered Raz

    Citation: Skeletal Muscle 2015 5:37

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  21. Content type: Research

    Satellite cells (SCs) are indispensable for muscle regeneration and repair; however, due to low frequency in primary muscle and loss of engraftment potential after ex vivo expansion, their use in cell therapy ...

    Authors: Antonio Filareto, Fabrizio Rinaldi, Robert W. Arpke, Radbod Darabi, Joseph J. Belanto, Erik A. Toso, Auston Z. Miller, James M. Ervasti, R. Scott McIvor, Michael Kyba and Rita CR Perlingeiro

    Citation: Skeletal Muscle 2015 5:36

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  22. Content type: Methodology

    Mouse models of dysferlinopathies are valuable tools with which to investigate the pathomechanisms underlying these diseases and to test novel therapeutic strategies. One such mouse model is the Dysf ...

    Authors: Tatiana Wiktorowicz, Jochen Kinter, Kazuhiro Kobuke, Kevin P. Campbell and Michael Sinnreich

    Citation: Skeletal Muscle 2015 5:32

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  23. Content type: Research

    Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational com...

    Authors: Jing Su, Carl Ekman, Nikolay Oskolkov, Leo Lahti, Kristoffer Ström, Alvis Brazma, Leif Groop, Johan Rung and Ola Hansson

    Citation: Skeletal Muscle 2015 5:35

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  24. Content type: Research

    Loss of skeletal muscle mass and function in humans is associated with significant morbidity and mortality. The role of myostatin as a key negative regulator of skeletal muscle mass and function has supported ...

    Authors: Esther Latres, Jeffrey Pangilinan, Lawrence Miloscio, Roy Bauerlein, Erqian Na, Terra B. Potocky, Ying Huang, Mark Eckersdorff, Ashique Rafique, Jason Mastaitis, Calvin Lin, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada and Trevor Stitt

    Citation: Skeletal Muscle 2015 5:34

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  25. Content type: Research

    Interleukin 15 (IL-15) is thought to be abundant in the skeletal muscle under steady state conditions based on RNA expression; however, the IL-15 RNA level may not reflect the protein level due to post-transcr...

    Authors: Po-Lin Huang, Mau-Sheng Hou, Szu-Wen Wang, Chin-Ling Chang, Yae-Huei Liou and Nan-Shih Liao

    Citation: Skeletal Muscle 2015 5:33

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  26. Content type: Research

    Syntaxins are a family of membrane proteins involved in vesicle trafficking, such as synaptic vesicle exocytosis. Syntaxin 4 (Stx4) is expressed highly in skeletal muscle and plays a critical role in insulin-s...

    Authors: Miran Yoo, Bok-Geon Kim, Sang-Jin Lee, Hyeon-Ju Jeong, Jong Woo Park, Dong-Wan Seo, Yong Kee Kim, Hoi Young Lee, Jeung-Whan Han, Jong-Sun Kang and Gyu-Un Bae

    Citation: Skeletal Muscle 2015 5:28

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  27. Content type: Research

    Merosin-deficient congenital muscular dystrophy type-1A (MDC1A) is characterized by progressive muscular dystrophy and dysmyelinating neuropathy caused by mutations of the α2 chain of laminin-211, the predomin...

    Authors: Teuta Domi, Emanuela Porrello, Daniele Velardo, Alessia Capotondo, Alessandra Biffi, Rossana Tonlorenzi, Stefano Amadio, Alessandro Ambrosi, Yuko Miyagoe-Suzuki, Shin’ichi Takeda, Markus A. Ruegg and Stefano Carlo Previtali

    Citation: Skeletal Muscle 2015 5:30

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  28. Content type: Case Report

    Transport protein particle (TRAPP) is a multiprotein complex involved in endoplasmic reticulum-to-Golgi trafficking. Zebrafish with a mutation in the TRAPPC11 orthologue showed hepatomegaly with steatosis and def...

    Authors: Wen-Chen Liang, Wenhua Zhu, Satomi Mitsuhashi, Satoru Noguchi, Michael Sacher, Megumu Ogawa, Hsiang-Hung Shih, Yuh-Jyh Jong and Ichizo Nishino

    Citation: Skeletal Muscle 2015 5:29

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  29. Content type: Research

    The plasma membranes of striated muscle cells are particularly susceptible to rupture as they endure significant mechanical stress and strain during muscle contraction, and studies have shown that defects in m...

    Authors: Kaitlin C. Lenhart, Thomas J. O’Neill IV, Zhaokang Cheng, Rachel Dee, Alexis R. Demonbreun, Jianbin Li, Xiao Xiao, Elizabeth M. McNally, Christopher P. Mack and Joan M. Taylor

    Citation: Skeletal Muscle 2015 5:27

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  30. Content type: Research

    In skeletal muscle, intracellular Ca2+ is an important regulator of contraction as well as gene expression and metabolic processes. Because of the difficulties to obtain intact human muscle fibers, human myotubes...

    Authors: Karl Olsson, Arthur J. Cheng, Seher Alam, Mamdoh Al-Ameri, Eric Rullman, Håkan Westerblad, Johanna T. Lanner, Joseph D. Bruton and Thomas Gustafsson

    Citation: Skeletal Muscle 2015 5:26

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  31. Content type: Research

    Loss-of-function mutations in the dysferlin gene (DYSF) result in a family of muscle disorders known collectively as the dysferlinopathies. Dysferlin-deficient muscle is characterized by inflammatory foci and ...

    Authors: Tatiana V. Cohen, Gina M. Many, Bryan D. Fleming, Viola F. Gnocchi, Svetlana Ghimbovschi, David M. Mosser, Eric P. Hoffman and Terence A. Partridge

    Citation: Skeletal Muscle 2015 5:24

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  32. Content type: Research

    The hormone adiponectin (ApN) is decreased in the metabolic syndrome, where it plays a key pathogenic role. ApN also exerts some anti-inflammatory effects on skeletal muscles in mice exposed to acute or chroni...

    Authors: Michel Abou-Samra, Sophie Lecompte, Olivier Schakman, Laurence Noel, Marie C. Many, Philippe Gailly and Sonia M. Brichard

    Citation: Skeletal Muscle 2015 5:25

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  33. Content type: Research

    Although excitation-contraction (EC) coupling in skeletal muscle relies on physical activation of the skeletal ryanodine receptor (RyR1) Ca2+ release channel by dihydropyridine receptors (DHPRs), the activation p...

    Authors: Robyn T. Rebbeck, Hermia Willemse, Linda Groom, Marco G. Casarotto, Philip G. Board, Nicole A. Beard, Robert T. Dirksen and Angela F. Dulhunty

    Citation: Skeletal Muscle 2015 5:23

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  34. Content type: Review

    Developing skeletal muscles express unique myosin isoforms, including embryonic and neonatal myosin heavy chains, coded by the myosin heavy chain 3 (MYH3) and MYH8 genes, respectively, and myosin light chain 1 em...

    Authors: Stefano Schiaffino, Alberto C. Rossi, Vika Smerdu, Leslie A. Leinwand and Carlo Reggiani

    Citation: Skeletal Muscle 2015 5:22

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  35. Content type: Research

    Myostatin is a protein synthesized and secreted by skeletal muscle that negatively regulates muscle mass. The extent to which circulating myostatin levels change in the context of aging is controversial, large...

    Authors: H. Robert Bergen III, Joshua N. Farr, Patrick M. Vanderboom, Elizabeth J. Atkinson, Thomas A. White, Ravinder J. Singh, Sundeep Khosla and Nathan K. LeBrasseur

    Citation: Skeletal Muscle 2015 5:21

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  36. Content type: Research

    In addition to the primary symptoms arising from inflamed joints, muscle weakness is prominent and frequent in patients with rheumatoid arthritis (RA). Here, we investigated the mechanisms of arthritis-induced...

    Authors: Takashi Yamada, Masami Abe, Jaesik Lee, Daisuke Tatebayashi, Koichi Himori, Keita Kanzaki, Masanobu Wada, Joseph D. Bruton, Håkan Westerblad and Johanna T. Lanner

    Citation: Skeletal Muscle 2015 5:20

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  37. Content type: Research

    Skeletal muscle is a major contributor to whole-body metabolism as it serves as a depot for both glucose and amino acids, and is a highly metabolically active tissue. Within skeletal muscle exists an intrinsic...

    Authors: Brian A Hodge, Yuan Wen, Lance A Riley, Xiping Zhang, Jonathan H England, Brianna D Harfmann, Elizabeth A Schroder and Karyn A Esser

    Citation: Skeletal Muscle 2015 5:17

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  38. Content type: Research

    Preclinical testing of potential therapies for Duchenne muscular dystrophy (DMD) is conducted predominantly of the mdx mouse. But lack of a detailed quantitative description of the pathology of this animal limits...

    Authors: William Duddy, Stephanie Duguez, Helen Johnston, Tatiana V Cohen, Aditi Phadke, Heather Gordish-Dressman, Kanneboyina Nagaraju, Viola Gnocchi, SiewHui Low and Terence Partridge

    Citation: Skeletal Muscle 2015 5:16

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  39. Content type: Methodology

    Duchenne muscular dystrophy (DMD) is due to mutations in the gene coding for human DMD; DMD is characterized by progressive muscle degeneration, inflammation, fat accumulation, and fibrosis. The mdx mouse model o...

    Authors: Leonel Martinez, Natalia V Ermolova, Tomo-O Ishikawa, David B Stout, Harvey R Herschman and Melissa J Spencer

    Citation: Skeletal Muscle 2015 5:15

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  40. Content type: Research

    Muscle stem cell transplantation is a possible treatment for muscular dystrophy. In addition to the intrinsic properties of the stem cells, the local and systemic environment plays an important role in determi...

    Authors: Jinhong Meng, Maximilien Bencze, Rowan Asfahani, Francesco Muntoni and Jennifer E Morgan

    Citation: Skeletal Muscle 2015 5:11

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  41. Content type: Research

    Adult skeletal muscle regeneration is a highly orchestrated process involving the activation and proliferation of satellite cells, an adult skeletal muscle stem cell. Activated satellite cells generate a trans...

    Authors: Andrew E Jones, Feodor D Price, Fabien Le Grand, Vahab D Soleimani, Sarah A Dick, Lynn A Megeney and Michael A Rudnicki

    Citation: Skeletal Muscle 2015 5:14

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  42. Content type: Research

    Nemaline myopathy (NM), the most common non-dystrophic congenital myopathy, is characterized by generalized skeletal muscle weakness, often from birth. To date, no therapy exists that enhances the contractile ...

    Authors: Josine M de Winter, Barbara Joureau, Vasco Sequeira, Nigel F Clarke, Jolanda van der Velden, Ger JM Stienen, Henk Granzier, Alan H Beggs and Coen AC Ottenheijm

    Citation: Skeletal Muscle 2015 5:12

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  43. Content type: Research

    The X-linked recessive disease Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding the protein dystrophin. Despite its large size, dystrophin is a highly stable protein, demonstrating...

    Authors: Jackie L McCourt, Katrina K Rhett, Michele A Jaeger, Joseph J Belanto, Dana M Talsness and James M Ervasti

    Citation: Skeletal Muscle 2015 5:13

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  44. Content type: Research

    Mutations in the gene encoding ryanodine receptor type-1 (RYR1), the calcium ion (Ca 2+) release channel in the sarcoplasmic reticulum (SR) of skeletal muscle, are linked to central ...

    Authors: Cecilia Paolini, Marco Quarta, Lan Wei-LaPierre, Antonio Michelucci, Alessandra Nori, Carlo Reggiani, Robert T Dirksen and Feliciano Protasi

    Citation: Skeletal Muscle 2015 5:10

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  45. Content type: Research

    Alterations in skeletal muscle contractile activity necessitate an efficient remodeling mechanism. In particular, mitochondrial turnover is essential for tissue homeostasis during muscle adaptations to chronic...

    Authors: Anna Vainshtein, Eric MA Desjardins, Andrea Armani, Marco Sandri and David A Hood

    Citation: Skeletal Muscle 2015 5:9

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  46. Content type: Research

    The effects of transforming growth factor-beta (TGFβ) are mediated by the transcription factors Smad2 and Smad3. During adult skeletal myogenesis, TGFβ signaling inhibits the differentiation of myoblasts, and ...

    Authors: Émilie Lamarche, Neena Lala-Tabbert, Angelo Gunanayagam, Catherine St-Louis and Nadine Wiper-Bergeron

    Citation: Skeletal Muscle 2015 5:8

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