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  1. Content type: Research

    Skeletal muscle is a major contributor to whole-body metabolism as it serves as a depot for both glucose and amino acids, and is a highly metabolically active tissue. Within skeletal muscle exists an intrinsic...

    Authors: Brian A Hodge, Yuan Wen, Lance A Riley, Xiping Zhang, Jonathan H England, Brianna D Harfmann, Elizabeth A Schroder and Karyn A Esser

    Citation: Skeletal Muscle 2015 5:17

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  2. Content type: Research

    Preclinical testing of potential therapies for Duchenne muscular dystrophy (DMD) is conducted predominantly of the mdx mouse. But lack of a detailed quantitative description of the pathology of this animal limits...

    Authors: William Duddy, Stephanie Duguez, Helen Johnston, Tatiana V Cohen, Aditi Phadke, Heather Gordish-Dressman, Kanneboyina Nagaraju, Viola Gnocchi, SiewHui Low and Terence Partridge

    Citation: Skeletal Muscle 2015 5:16

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  3. Content type: Methodology

    Duchenne muscular dystrophy (DMD) is due to mutations in the gene coding for human DMD; DMD is characterized by progressive muscle degeneration, inflammation, fat accumulation, and fibrosis. The mdx mouse model o...

    Authors: Leonel Martinez, Natalia V Ermolova, Tomo-O Ishikawa, David B Stout, Harvey R Herschman and Melissa J Spencer

    Citation: Skeletal Muscle 2015 5:15

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  4. Content type: Research

    Adult skeletal muscle regeneration is a highly orchestrated process involving the activation and proliferation of satellite cells, an adult skeletal muscle stem cell. Activated satellite cells generate a trans...

    Authors: Andrew E Jones, Feodor D Price, Fabien Le Grand, Vahab D Soleimani, Sarah A Dick, Lynn A Megeney and Michael A Rudnicki

    Citation: Skeletal Muscle 2015 5:14

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  5. Content type: Research

    The X-linked recessive disease Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding the protein dystrophin. Despite its large size, dystrophin is a highly stable protein, demonstrating...

    Authors: Jackie L McCourt, Katrina K Rhett, Michele A Jaeger, Joseph J Belanto, Dana M Talsness and James M Ervasti

    Citation: Skeletal Muscle 2015 5:13

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  6. Content type: Research

    Nemaline myopathy (NM), the most common non-dystrophic congenital myopathy, is characterized by generalized skeletal muscle weakness, often from birth. To date, no therapy exists that enhances the contractile ...

    Authors: Josine M de Winter, Barbara Joureau, Vasco Sequeira, Nigel F Clarke, Jolanda van der Velden, Ger JM Stienen, Henk Granzier, Alan H Beggs and Coen AC Ottenheijm

    Citation: Skeletal Muscle 2015 5:12

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  7. Content type: Research

    Muscle stem cell transplantation is a possible treatment for muscular dystrophy. In addition to the intrinsic properties of the stem cells, the local and systemic environment plays an important role in determi...

    Authors: Jinhong Meng, Maximilien Bencze, Rowan Asfahani, Francesco Muntoni and Jennifer E Morgan

    Citation: Skeletal Muscle 2015 5:11

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  8. Content type: Research

    Mutations in the gene encoding ryanodine receptor type-1 (RYR1), the calcium ion (Ca 2+) release channel in the sarcoplasmic reticulum (SR) of skeletal muscle, are linked to central ...

    Authors: Cecilia Paolini, Marco Quarta, Lan Wei-LaPierre, Antonio Michelucci, Alessandra Nori, Carlo Reggiani, Robert T Dirksen and Feliciano Protasi

    Citation: Skeletal Muscle 2015 5:10

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  9. Content type: Research

    Alterations in skeletal muscle contractile activity necessitate an efficient remodeling mechanism. In particular, mitochondrial turnover is essential for tissue homeostasis during muscle adaptations to chronic...

    Authors: Anna Vainshtein, Eric MA Desjardins, Andrea Armani, Marco Sandri and David A Hood

    Citation: Skeletal Muscle 2015 5:9

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  10. Content type: Research

    The effects of transforming growth factor-beta (TGFβ) are mediated by the transcription factors Smad2 and Smad3. During adult skeletal myogenesis, TGFβ signaling inhibits the differentiation of myoblasts, and ...

    Authors: Émilie Lamarche, Neena Lala-Tabbert, Angelo Gunanayagam, Catherine St-Louis and Nadine Wiper-Bergeron

    Citation: Skeletal Muscle 2015 5:8

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  11. Content type: Research

    Skeletal muscle is the most abundant tissue in the body and is a major source of total energy expenditure in mammals. Skeletal muscle consists of fast and slow fiber types, which differ in their energy usage, ...

    Authors: Courtney M Anderson, Jianxin Hu, Ralston M Barnes, Analeah B Heidt, Ivo Cornelissen and Brian L Black

    Citation: Skeletal Muscle 2015 5:7

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  12. Content type: Research

    Skeletal muscle function depends on calcium signaling proteins in the sarcoplasmic reticulum (SR), including the calcium-binding protein calsequestrin (CSQ), the ryanodine receptor (RyR) calcium release channe...

    Authors: Nicole A Beard and Angela F Dulhunty

    Citation: Skeletal Muscle 2015 5:6

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  13. Content type: Research

    The stiffness of the myogenic stem cell microenvironment markedly influences the ability to regenerate tissue. We studied the effect of damaged myofibers on myogenic progenitor cell (MPC) proliferation and det...

    Authors: Frédéric Trensz, Fabrice Lucien, Vanessa Couture, Thomas Söllrald, Geneviève Drouin, André-Jean Rouleau, Michel Grandbois, Gregory Lacraz and Guillaume Grenier

    Citation: Skeletal Muscle 2015 5:5

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    The Erratum to this article has been published in Skeletal Muscle 2016 6:37

    The Erratum to this article has been published in Skeletal Muscle 2015 5:31

  14. Content type: Research

    Ca2+ influx through CaV1.1 is not required for skeletal muscle excitation-contraction coupling, but whether Ca2+ permeation through CaV1.1 during sustained muscle activity plays a functional role in mammalian ske...

    Authors: Chang Seok Lee, Adan Dagnino-Acosta, Viktor Yarotskyy, Amy Hanna, Alla Lyfenko, Mark Knoblauch, Dimitra K Georgiou, Ross A Poché, Michael W Swank, Cheng Long, Iskander I Ismailov, Johanna Lanner, Ted Tran, KeKe Dong, George G Rodney, Mary E Dickinson…

    Citation: Skeletal Muscle 2015 5:4

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  15. Content type: Research

    Cell surface glycans are known to play vital roles in muscle membrane stability and muscle disease, but to date, roles for glycans in muscle regeneration have been less well understood. Here, we describe a rol...

    Authors: Neha Singhal and Paul T Martin

    Citation: Skeletal Muscle 2015 5:3

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  16. Content type: Research

    The transcription factor Sox6 has been implicated in regulating muscle fiber type-specific gene expression in mammals. In zebrafish, loss of function of the transcription factor Prdm1a results in a slow to fas...

    Authors: Harriet E Jackson, Yosuke Ono, Xingang Wang, Stone Elworthy, Vincent T Cunliffe and Philip W Ingham

    Citation: Skeletal Muscle 2015 5:2

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  17. Content type: Research

    Congenital and inherited myopathies in dogs are faithful models of human muscle diseases and are being recognized with increasing frequency. In fact, canine models of dystrophin deficient muscular dystrophy an...

    Authors: G Diane Shelton, Branden E Rider, Georgina Child, Sophia Tzannes, Ling T Guo, Behzad Moghadaszadeh, Emily C Troiano, Bianca Haase, Claire M Wade and Alan H Beggs

    Citation: Skeletal Muscle 2015 5:1

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  18. Content type: Commentary

    Two recent studies have reinvigorated the conversation regarding the role of Pax7 in adult satellite. Studies by Gunther et al (Cell Stem Cell 13: 590–601, 2013) and Von Maltzhen et al (Proc Natl Acad Sci U S A 1...

    Authors: Andrew S Brack

    Citation: Skeletal Muscle 2014 4:24

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  19. Content type: Research

    Nitric oxide (NO), generated in skeletal muscle mostly by the neuronal NO synthases (nNOSμ), has profound effects on both mitochondrial bioenergetics and muscle development and function. The importance of NO f...

    Authors: Clara De Palma, Federica Morisi, Sarah Pambianco, Emma Assi, Thierry Touvier, Stefania Russo, Cristiana Perrotta, Vanina Romanello, Silvia Carnio, Valentina Cappello, Paolo Pellegrino, Claudia Moscheni, Maria Teresa Bassi, Marco Sandri, Davide Cervia and Emilio Clementi

    Citation: Skeletal Muscle 2014 4:22

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  20. Content type: Research

    Circulating angiotensin II (AngII) is elevated in congestive heart failure (CHF), and leads to skeletal muscle wasting, which is strongly associated with poor patient outcomes. We previously found that AngII u...

    Authors: Alexander Michael Tabony, Tadashi Yoshida, Sergiy Sukhanov and Patrice Delafontaine

    Citation: Skeletal Muscle 2014 4:20

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  21. Content type: Research

    The most common form of facioscapulohumeral muscular dystrophy (FSHD) is caused by a genetic contraction of the polymorphic D4Z4 macrosatellite repeat array in the subtelomeric region of chromosome 4q. In some...

    Authors: Peter E Thijssen, Judit Balog, Zizhen Yao, Tan Phát Pham, Rabi Tawil, Stephen J Tapscott and Silvère M Van der Maarel

    Citation: Skeletal Muscle 2014 4:19

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  22. Content type: Research

    Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene and afflicts skeletal and cardiac muscles. Previous studies showed that DMD is associated with constitutive activation of NF-κB, ...

    Authors: Joe N Kornegay, Jennifer M Peterson, Daniel J Bogan, William Kline, Janet R Bogan, Jennifer L Dow, Zheng Fan, Jiahui Wang, Mihye Ahn, Hongtu Zhu, Martin Styner and Denis C Guttridge

    Citation: Skeletal Muscle 2014 4:18

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  23. Content type: Methodology

    Fibrosis, an excessive collagen accumulation, results in scar formation, impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies, including the lethal Duchenne muscular d...

    Authors: Patrizia Pessina, Daniel Cabrera, María Gabriela Morales, Cecilia A Riquelme, Jaime Gutiérrez, Antonio L Serrano, Enrique Brandan and Pura Muñoz-Cánoves

    Citation: Skeletal Muscle 2014 4:7

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  24. Content type: Research

    The idiopathic inflammatory myopathies represent a group of autoimmune diseases that are characterized by lymphocyte infiltration of muscle and muscle weakness. Insulin-like 6 (Insl6) is a poorly characterized...

    Authors: Ling Zeng, Sonomi Maruyama, Kazuto Nakamura, Jennifer L Parker-Duffen, Ibrahim M Adham, Xuemei Zhong, Han-Kyu Lee, Henry Querfurth and Kenneth Walsh

    Citation: Skeletal Muscle 2014 4:16

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  25. Content type: Research

    Nemaline myopathy (NM) is a rare genetic muscle disorder, but one of the most common among the congenital myopathies. NM is caused by mutations in at least nine genes: Nebulin (NEB), α-actin (ACTA1), α-tropomyosi...

    Authors: Minttu Marttila, Mubashir Hanif, Elina Lemola, Kristen J Nowak, Jenni Laitila, Mikaela Grönholm, Carina Wallgren-Pettersson and Katarina Pelin

    Citation: Skeletal Muscle 2014 4:15

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  26. Content type: Research

    MDC1A is a congenital neuromuscular disorder with developmentally complex and progressive pathologies that results from a deficiency in the protein laminin α2. MDC1A is associated with a multitude of pathologies,...

    Authors: Thomas Mehuron, Ajay Kumar, Lina Duarte, Jenny Yamauchi, Anthony Accorsi and Mahasweta Girgenrath

    Citation: Skeletal Muscle 2014 4:14

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    The Erratum to this article has been published in Skeletal Muscle 2014 4:17

  27. Content type: Research

    The dystrophin glycoprotein complex (DGC) is located at the sarcolemma of muscle fibers, providing structural integrity. Mutations in and loss of DGC proteins cause a spectrum of muscular dystrophies. When onl...

    Authors: Catherine Moorwood, Anastassios Philippou, Janelle Spinazzola, Benjamin Keyser, Edward J Macarak and Elisabeth R Barton

    Citation: Skeletal Muscle 2014 4:13

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  28. Content type: Research

    Muscle hypertrophy in the mdx mouse model of Duchenne muscular dystrophy (DMD) can partially compensate for the loss of dystrophin by maintaining peak force production. Histopathology examination of the hypertrop...

    Authors: Rachel M Faber, John K Hall, Jeffrey S Chamberlain and Glen B Banks

    Citation: Skeletal Muscle 2014 4:10

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  29. Content type: Research

    Duchenne muscular dystrophy (DMD) is characterized by the absence of the cytoskeletal protein dystrophin, muscle wasting, increased transforming growth factor type beta (TGF-β) signaling, and fibrosis. At the ...

    Authors: Daniel Cabrera, Jaime Gutiérrez, Claudio Cabello-Verrugio, Maria Gabriela Morales, Sergio Mezzano, Ricardo Fadic, Juan Carlos Casar, Juan L Hancke and Enrique Brandan

    Citation: Skeletal Muscle 2014 4:6

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  30. Content type: Research

    Via the hepatocyte growth factor receptor (Met), hepatocyte growth factor (HGF) exerts key roles involving skeletal muscle development and regeneration. Heparan sulfate proteoglycans (HSPGs) are critical modul...

    Authors: Jaime Gutiérrez, Daniel Cabrera and Enrique Brandan

    Citation: Skeletal Muscle 2014 4:5

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  31. Content type: Research

    Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic alterations at the D4Z4 macrosatellite repeat locus on chromosome 4, resulting in inappropriate expression of the DUX4 protein. The DUX4 pr...

    Authors: Darko Bosnakovski, Si Ho Choi, Jessica M Strasser, Erik A Toso, Michael A Walters and Michael Kyba

    Citation: Skeletal Muscle 2014 4:4

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  32. Content type: Research

    Duchenne muscle dystrophy (DMD) afflicts 1 million boys in the US and has few effective treatments. Constitutive transgenic expression of the transcriptional coactivator peroxisome proliferator-activated recep...

    Authors: Mun Chun Chan, Glenn C Rowe, Srilatha Raghuram, Ian S Patten, Caitlin Farrell and Zolt Arany

    Citation: Skeletal Muscle 2014 4:2

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  33. Content type: Research

    The NFATc transcription factor family is responsible for coupling cytoplasmic calcium signals to transcription programs in a wide variety of cell types. In skeletal muscle, these transcription factors control ...

    Authors: Patrick Robison, Erick O Hernández-Ochoa and Martin F Schneider

    Citation: Skeletal Muscle 2014 4:1

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  34. Content type: Case report

    Heterotopic ossification (HO) is defined as the abnormal formation of mature bone in soft tissue, notably skeletal muscle. The morbidity of HO in polytraumatized patients impacts the functional outcome, impair...

    Authors: Guillaume Grenier, Élisabeth Leblanc, Nathalie Faucheux, Dominique Lauzier, Peter Kloen and Reggie C Hamdy

    Citation: Skeletal Muscle 2013 3:29

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  35. Content type: Research

    Congenital muscular dystrophy Type 1A (MDC1A) is a severe, recessive disease of childhood onset that is caused by mutations in the LAMA2 gene encoding laminin-α2. Studies with both mouse models and primary cultur...

    Authors: Soonsang Yoon, Guido Stadler, Mary Lou Beermann, Eric V Schmidt, James A Windelborn, Peter Schneiderat, Woodring E Wright and Jeffrey Boone Miller

    Citation: Skeletal Muscle 2013 3:28

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  36. Content type: Research

    Alveolar rhabdomyosarcoma (aRMS) is a myogenic childhood sarcoma frequently associated with a translocation-mediated fusion gene, Pax3:Foxo1a.

    Authors: Ken Kikuchi, Eri Taniguchi, Hung-I Harry Chen, Matthew N Svalina, Jinu Abraham, Elaine T Huang, Koichi Nishijo, Sean Davis, Christopher Louden, Lee Ann Zarzabal, Olivia Recht, Ayeza Bajwa, Noah Berlow, Mònica Suelves, Sherrie L Perkins, Paul S Meltzer…

    Citation: Skeletal Muscle 2013 3:27

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  37. Content type: Research

    Musculin (MSC) is a basic helix-loop-helix transcription factor that inhibits myogenesis during normal development and contributes to the differentiation defect in rhabdomyosarcoma. As one of many transcriptio...

    Authors: Kyle L MacQuarrie, Zizhen Yao, Abraham P Fong and Stephen J Tapscott

    Citation: Skeletal Muscle 2013 3:26

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  38. Content type: Commentary

    Mitsugumin 53 (MG53) is a relatively newly identified tripartite motif-containing (TRIM) family muscle-specific E3 ubiquitin ligase that is expressed in skeletal muscle and the heart. It has been postulated to...

    Authors: Jennifer R Levy, Kevin P Campbell and David J Glass

    Citation: Skeletal Muscle 2013 3:25

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  39. Content type: Research

    The childhood neuromuscular disease spinal muscular atrophy (SMA) is caused by mutations or deletions of the survival motor neuron (SMN1) gene. Although SMA has traditionally been considered a motor neuron diseas...

    Authors: Justin G Boyer, Lyndsay M Murray, Kyle Scott, Yves De Repentigny, Jean-Marc Renaud and Rashmi Kothary

    Citation: Skeletal Muscle 2013 3:24

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  40. Content type: Research

    The nuclear poly(A) binding protein 1 (PABPN1) is a ubiquitously expressed proteinthat plays critical roles at multiple steps in post-transcriptional regulation ofgene expression. Short expansions of the polya...

    Authors: Luciano H Apponi, Anita H Corbett and Grace K Pavlath

    Citation: Skeletal Muscle 2013 3:23

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  41. Content type: Research

    Phosphatidylinositol phosphates (PIPs) are low-abundance phospholipids that participate in a range of cellular processes, including cell migration and membrane traffic. PIP levels and subcellular distribution ...

    Authors: Aaron Reifler, Guy M Lenk, Xingli Li, Linda Groom, Susan V Brooks, Desmond Wilson, Michyla Bowerson, Robert T Dirksen, Miriam H Meisler and James J Dowling

    Citation: Skeletal Muscle 2013 3:21

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