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  1. Content type: Research

    Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational com...

    Authors: Jing Su, Carl Ekman, Nikolay Oskolkov, Leo Lahti, Kristoffer Ström, Alvis Brazma, Leif Groop, Johan Rung and Ola Hansson

    Citation: Skeletal Muscle 2015 5:35

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  2. Content type: Research

    Interleukin 15 (IL-15) is thought to be abundant in the skeletal muscle under steady state conditions based on RNA expression; however, the IL-15 RNA level may not reflect the protein level due to post-transcr...

    Authors: Po-Lin Huang, Mau-Sheng Hou, Szu-Wen Wang, Chin-Ling Chang, Yae-Huei Liou and Nan-Shih Liao

    Citation: Skeletal Muscle 2015 5:33

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  3. Content type: Research

    Syntaxins are a family of membrane proteins involved in vesicle trafficking, such as synaptic vesicle exocytosis. Syntaxin 4 (Stx4) is expressed highly in skeletal muscle and plays a critical role in insulin-s...

    Authors: Miran Yoo, Bok-Geon Kim, Sang-Jin Lee, Hyeon-Ju Jeong, Jong Woo Park, Dong-Wan Seo, Yong Kee Kim, Hoi Young Lee, Jeung-Whan Han, Jong-Sun Kang and Gyu-Un Bae

    Citation: Skeletal Muscle 2015 5:28

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  4. Content type: Research

    Merosin-deficient congenital muscular dystrophy type-1A (MDC1A) is characterized by progressive muscular dystrophy and dysmyelinating neuropathy caused by mutations of the α2 chain of laminin-211, the predomin...

    Authors: Teuta Domi, Emanuela Porrello, Daniele Velardo, Alessia Capotondo, Alessandra Biffi, Rossana Tonlorenzi, Stefano Amadio, Alessandro Ambrosi, Yuko Miyagoe-Suzuki, Shin’ichi Takeda, Markus A. Ruegg and Stefano Carlo Previtali

    Citation: Skeletal Muscle 2015 5:30

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  5. Content type: Case Report

    Transport protein particle (TRAPP) is a multiprotein complex involved in endoplasmic reticulum-to-Golgi trafficking. Zebrafish with a mutation in the TRAPPC11 orthologue showed hepatomegaly with steatosis and def...

    Authors: Wen-Chen Liang, Wenhua Zhu, Satomi Mitsuhashi, Satoru Noguchi, Michael Sacher, Megumu Ogawa, Hsiang-Hung Shih, Yuh-Jyh Jong and Ichizo Nishino

    Citation: Skeletal Muscle 2015 5:29

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  6. Content type: Research

    The plasma membranes of striated muscle cells are particularly susceptible to rupture as they endure significant mechanical stress and strain during muscle contraction, and studies have shown that defects in m...

    Authors: Kaitlin C. Lenhart, Thomas J. O’Neill IV, Zhaokang Cheng, Rachel Dee, Alexis R. Demonbreun, Jianbin Li, Xiao Xiao, Elizabeth M. McNally, Christopher P. Mack and Joan M. Taylor

    Citation: Skeletal Muscle 2015 5:27

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  7. Content type: Research

    In skeletal muscle, intracellular Ca2+ is an important regulator of contraction as well as gene expression and metabolic processes. Because of the difficulties to obtain intact human muscle fibers, human myotubes...

    Authors: Karl Olsson, Arthur J. Cheng, Seher Alam, Mamdoh Al-Ameri, Eric Rullman, Håkan Westerblad, Johanna T. Lanner, Joseph D. Bruton and Thomas Gustafsson

    Citation: Skeletal Muscle 2015 5:26

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  8. Content type: Research

    The hormone adiponectin (ApN) is decreased in the metabolic syndrome, where it plays a key pathogenic role. ApN also exerts some anti-inflammatory effects on skeletal muscles in mice exposed to acute or chroni...

    Authors: Michel Abou-Samra, Sophie Lecompte, Olivier Schakman, Laurence Noel, Marie C. Many, Philippe Gailly and Sonia M. Brichard

    Citation: Skeletal Muscle 2015 5:25

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  9. Content type: Research

    Loss-of-function mutations in the dysferlin gene (DYSF) result in a family of muscle disorders known collectively as the dysferlinopathies. Dysferlin-deficient muscle is characterized by inflammatory foci and ...

    Authors: Tatiana V. Cohen, Gina M. Many, Bryan D. Fleming, Viola F. Gnocchi, Svetlana Ghimbovschi, David M. Mosser, Eric P. Hoffman and Terence A. Partridge

    Citation: Skeletal Muscle 2015 5:24

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  10. Content type: Research

    Although excitation-contraction (EC) coupling in skeletal muscle relies on physical activation of the skeletal ryanodine receptor (RyR1) Ca2+ release channel by dihydropyridine receptors (DHPRs), the activation p...

    Authors: Robyn T. Rebbeck, Hermia Willemse, Linda Groom, Marco G. Casarotto, Philip G. Board, Nicole A. Beard, Robert T. Dirksen and Angela F. Dulhunty

    Citation: Skeletal Muscle 2015 5:23

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  11. Content type: Review

    Developing skeletal muscles express unique myosin isoforms, including embryonic and neonatal myosin heavy chains, coded by the myosin heavy chain 3 (MYH3) and MYH8 genes, respectively, and myosin light chain 1 em...

    Authors: Stefano Schiaffino, Alberto C. Rossi, Vika Smerdu, Leslie A. Leinwand and Carlo Reggiani

    Citation: Skeletal Muscle 2015 5:22

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  12. Content type: Research

    Myostatin is a protein synthesized and secreted by skeletal muscle that negatively regulates muscle mass. The extent to which circulating myostatin levels change in the context of aging is controversial, large...

    Authors: H. Robert Bergen III, Joshua N. Farr, Patrick M. Vanderboom, Elizabeth J. Atkinson, Thomas A. White, Ravinder J. Singh, Sundeep Khosla and Nathan K. LeBrasseur

    Citation: Skeletal Muscle 2015 5:21

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  13. Content type: Research

    In addition to the primary symptoms arising from inflamed joints, muscle weakness is prominent and frequent in patients with rheumatoid arthritis (RA). Here, we investigated the mechanisms of arthritis-induced...

    Authors: Takashi Yamada, Masami Abe, Jaesik Lee, Daisuke Tatebayashi, Koichi Himori, Keita Kanzaki, Masanobu Wada, Joseph D. Bruton, Håkan Westerblad and Johanna T. Lanner

    Citation: Skeletal Muscle 2015 5:20

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  14. Content type: Research

    Skeletal muscle is a major contributor to whole-body metabolism as it serves as a depot for both glucose and amino acids, and is a highly metabolically active tissue. Within skeletal muscle exists an intrinsic...

    Authors: Brian A Hodge, Yuan Wen, Lance A Riley, Xiping Zhang, Jonathan H England, Brianna D Harfmann, Elizabeth A Schroder and Karyn A Esser

    Citation: Skeletal Muscle 2015 5:17

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  15. Content type: Research

    Preclinical testing of potential therapies for Duchenne muscular dystrophy (DMD) is conducted predominantly of the mdx mouse. But lack of a detailed quantitative description of the pathology of this animal limits...

    Authors: William Duddy, Stephanie Duguez, Helen Johnston, Tatiana V Cohen, Aditi Phadke, Heather Gordish-Dressman, Kanneboyina Nagaraju, Viola Gnocchi, SiewHui Low and Terence Partridge

    Citation: Skeletal Muscle 2015 5:16

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  16. Content type: Methodology

    Duchenne muscular dystrophy (DMD) is due to mutations in the gene coding for human DMD; DMD is characterized by progressive muscle degeneration, inflammation, fat accumulation, and fibrosis. The mdx mouse model o...

    Authors: Leonel Martinez, Natalia V Ermolova, Tomo-O Ishikawa, David B Stout, Harvey R Herschman and Melissa J Spencer

    Citation: Skeletal Muscle 2015 5:15

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  17. Content type: Research

    Adult skeletal muscle regeneration is a highly orchestrated process involving the activation and proliferation of satellite cells, an adult skeletal muscle stem cell. Activated satellite cells generate a trans...

    Authors: Andrew E Jones, Feodor D Price, Fabien Le Grand, Vahab D Soleimani, Sarah A Dick, Lynn A Megeney and Michael A Rudnicki

    Citation: Skeletal Muscle 2015 5:14

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  18. Content type: Research

    The X-linked recessive disease Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding the protein dystrophin. Despite its large size, dystrophin is a highly stable protein, demonstrating...

    Authors: Jackie L McCourt, Katrina K Rhett, Michele A Jaeger, Joseph J Belanto, Dana M Talsness and James M Ervasti

    Citation: Skeletal Muscle 2015 5:13

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  19. Content type: Research

    Nemaline myopathy (NM), the most common non-dystrophic congenital myopathy, is characterized by generalized skeletal muscle weakness, often from birth. To date, no therapy exists that enhances the contractile ...

    Authors: Josine M de Winter, Barbara Joureau, Vasco Sequeira, Nigel F Clarke, Jolanda van der Velden, Ger JM Stienen, Henk Granzier, Alan H Beggs and Coen AC Ottenheijm

    Citation: Skeletal Muscle 2015 5:12

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  20. Content type: Research

    Muscle stem cell transplantation is a possible treatment for muscular dystrophy. In addition to the intrinsic properties of the stem cells, the local and systemic environment plays an important role in determi...

    Authors: Jinhong Meng, Maximilien Bencze, Rowan Asfahani, Francesco Muntoni and Jennifer E Morgan

    Citation: Skeletal Muscle 2015 5:11

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  21. Content type: Research

    Mutations in the gene encoding ryanodine receptor type-1 (RYR1), the calcium ion (Ca 2+) release channel in the sarcoplasmic reticulum (SR) of skeletal muscle, are linked to central ...

    Authors: Cecilia Paolini, Marco Quarta, Lan Wei-LaPierre, Antonio Michelucci, Alessandra Nori, Carlo Reggiani, Robert T Dirksen and Feliciano Protasi

    Citation: Skeletal Muscle 2015 5:10

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  22. Content type: Research

    Alterations in skeletal muscle contractile activity necessitate an efficient remodeling mechanism. In particular, mitochondrial turnover is essential for tissue homeostasis during muscle adaptations to chronic...

    Authors: Anna Vainshtein, Eric MA Desjardins, Andrea Armani, Marco Sandri and David A Hood

    Citation: Skeletal Muscle 2015 5:9

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  23. Content type: Research

    The effects of transforming growth factor-beta (TGFβ) are mediated by the transcription factors Smad2 and Smad3. During adult skeletal myogenesis, TGFβ signaling inhibits the differentiation of myoblasts, and ...

    Authors: Émilie Lamarche, Neena Lala-Tabbert, Angelo Gunanayagam, Catherine St-Louis and Nadine Wiper-Bergeron

    Citation: Skeletal Muscle 2015 5:8

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  24. Content type: Research

    Skeletal muscle is the most abundant tissue in the body and is a major source of total energy expenditure in mammals. Skeletal muscle consists of fast and slow fiber types, which differ in their energy usage, ...

    Authors: Courtney M Anderson, Jianxin Hu, Ralston M Barnes, Analeah B Heidt, Ivo Cornelissen and Brian L Black

    Citation: Skeletal Muscle 2015 5:7

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  25. Content type: Research

    Skeletal muscle function depends on calcium signaling proteins in the sarcoplasmic reticulum (SR), including the calcium-binding protein calsequestrin (CSQ), the ryanodine receptor (RyR) calcium release channe...

    Authors: Nicole A Beard and Angela F Dulhunty

    Citation: Skeletal Muscle 2015 5:6

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  26. Content type: Research

    The stiffness of the myogenic stem cell microenvironment markedly influences the ability to regenerate tissue. We studied the effect of damaged myofibers on myogenic progenitor cell (MPC) proliferation and det...

    Authors: Frédéric Trensz, Fabrice Lucien, Vanessa Couture, Thomas Söllrald, Geneviève Drouin, André-Jean Rouleau, Michel Grandbois, Gregory Lacraz and Guillaume Grenier

    Citation: Skeletal Muscle 2015 5:5

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    The Erratum to this article has been published in Skeletal Muscle 2016 6:37

    The Erratum to this article has been published in Skeletal Muscle 2015 5:31

  27. Content type: Research

    Ca2+ influx through CaV1.1 is not required for skeletal muscle excitation-contraction coupling, but whether Ca2+ permeation through CaV1.1 during sustained muscle activity plays a functional role in mammalian ske...

    Authors: Chang Seok Lee, Adan Dagnino-Acosta, Viktor Yarotskyy, Amy Hanna, Alla Lyfenko, Mark Knoblauch, Dimitra K Georgiou, Ross A Poché, Michael W Swank, Cheng Long, Iskander I Ismailov, Johanna Lanner, Ted Tran, KeKe Dong, George G Rodney, Mary E Dickinson…

    Citation: Skeletal Muscle 2015 5:4

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  28. Content type: Research

    Cell surface glycans are known to play vital roles in muscle membrane stability and muscle disease, but to date, roles for glycans in muscle regeneration have been less well understood. Here, we describe a rol...

    Authors: Neha Singhal and Paul T Martin

    Citation: Skeletal Muscle 2015 5:3

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  29. Content type: Research

    The transcription factor Sox6 has been implicated in regulating muscle fiber type-specific gene expression in mammals. In zebrafish, loss of function of the transcription factor Prdm1a results in a slow to fas...

    Authors: Harriet E Jackson, Yosuke Ono, Xingang Wang, Stone Elworthy, Vincent T Cunliffe and Philip W Ingham

    Citation: Skeletal Muscle 2015 5:2

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  30. Content type: Research

    Congenital and inherited myopathies in dogs are faithful models of human muscle diseases and are being recognized with increasing frequency. In fact, canine models of dystrophin deficient muscular dystrophy an...

    Authors: G Diane Shelton, Branden E Rider, Georgina Child, Sophia Tzannes, Ling T Guo, Behzad Moghadaszadeh, Emily C Troiano, Bianca Haase, Claire M Wade and Alan H Beggs

    Citation: Skeletal Muscle 2015 5:1

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  31. Content type: Commentary

    Two recent studies have reinvigorated the conversation regarding the role of Pax7 in adult satellite. Studies by Gunther et al (Cell Stem Cell 13: 590–601, 2013) and Von Maltzhen et al (Proc Natl Acad Sci U S A 1...

    Authors: Andrew S Brack

    Citation: Skeletal Muscle 2014 4:24

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  32. Content type: Research

    Nitric oxide (NO), generated in skeletal muscle mostly by the neuronal NO synthases (nNOSμ), has profound effects on both mitochondrial bioenergetics and muscle development and function. The importance of NO f...

    Authors: Clara De Palma, Federica Morisi, Sarah Pambianco, Emma Assi, Thierry Touvier, Stefania Russo, Cristiana Perrotta, Vanina Romanello, Silvia Carnio, Valentina Cappello, Paolo Pellegrino, Claudia Moscheni, Maria Teresa Bassi, Marco Sandri, Davide Cervia and Emilio Clementi

    Citation: Skeletal Muscle 2014 4:22

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  33. Content type: Research

    Circulating angiotensin II (AngII) is elevated in congestive heart failure (CHF), and leads to skeletal muscle wasting, which is strongly associated with poor patient outcomes. We previously found that AngII u...

    Authors: Alexander Michael Tabony, Tadashi Yoshida, Sergiy Sukhanov and Patrice Delafontaine

    Citation: Skeletal Muscle 2014 4:20

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  34. Content type: Research

    The most common form of facioscapulohumeral muscular dystrophy (FSHD) is caused by a genetic contraction of the polymorphic D4Z4 macrosatellite repeat array in the subtelomeric region of chromosome 4q. In some...

    Authors: Peter E Thijssen, Judit Balog, Zizhen Yao, Tan Phát Pham, Rabi Tawil, Stephen J Tapscott and Silvère M Van der Maarel

    Citation: Skeletal Muscle 2014 4:19

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  35. Content type: Research

    Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene and afflicts skeletal and cardiac muscles. Previous studies showed that DMD is associated with constitutive activation of NF-κB, ...

    Authors: Joe N Kornegay, Jennifer M Peterson, Daniel J Bogan, William Kline, Janet R Bogan, Jennifer L Dow, Zheng Fan, Jiahui Wang, Mihye Ahn, Hongtu Zhu, Martin Styner and Denis C Guttridge

    Citation: Skeletal Muscle 2014 4:18

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  36. Content type: Methodology

    Fibrosis, an excessive collagen accumulation, results in scar formation, impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies, including the lethal Duchenne muscular d...

    Authors: Patrizia Pessina, Daniel Cabrera, María Gabriela Morales, Cecilia A Riquelme, Jaime Gutiérrez, Antonio L Serrano, Enrique Brandan and Pura Muñoz-Cánoves

    Citation: Skeletal Muscle 2014 4:7

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  37. Content type: Research

    The idiopathic inflammatory myopathies represent a group of autoimmune diseases that are characterized by lymphocyte infiltration of muscle and muscle weakness. Insulin-like 6 (Insl6) is a poorly characterized...

    Authors: Ling Zeng, Sonomi Maruyama, Kazuto Nakamura, Jennifer L Parker-Duffen, Ibrahim M Adham, Xuemei Zhong, Han-Kyu Lee, Henry Querfurth and Kenneth Walsh

    Citation: Skeletal Muscle 2014 4:16

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  38. Content type: Research

    Nemaline myopathy (NM) is a rare genetic muscle disorder, but one of the most common among the congenital myopathies. NM is caused by mutations in at least nine genes: Nebulin (NEB), α-actin (ACTA1), α-tropomyosi...

    Authors: Minttu Marttila, Mubashir Hanif, Elina Lemola, Kristen J Nowak, Jenni Laitila, Mikaela Grönholm, Carina Wallgren-Pettersson and Katarina Pelin

    Citation: Skeletal Muscle 2014 4:15

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  39. Content type: Research

    MDC1A is a congenital neuromuscular disorder with developmentally complex and progressive pathologies that results from a deficiency in the protein laminin α2. MDC1A is associated with a multitude of pathologies,...

    Authors: Thomas Mehuron, Ajay Kumar, Lina Duarte, Jenny Yamauchi, Anthony Accorsi and Mahasweta Girgenrath

    Citation: Skeletal Muscle 2014 4:14

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    The Erratum to this article has been published in Skeletal Muscle 2014 4:17

  40. Content type: Research

    The dystrophin glycoprotein complex (DGC) is located at the sarcolemma of muscle fibers, providing structural integrity. Mutations in and loss of DGC proteins cause a spectrum of muscular dystrophies. When onl...

    Authors: Catherine Moorwood, Anastassios Philippou, Janelle Spinazzola, Benjamin Keyser, Edward J Macarak and Elisabeth R Barton

    Citation: Skeletal Muscle 2014 4:13

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  41. Content type: Research

    Muscle hypertrophy in the mdx mouse model of Duchenne muscular dystrophy (DMD) can partially compensate for the loss of dystrophin by maintaining peak force production. Histopathology examination of the hypertrop...

    Authors: Rachel M Faber, John K Hall, Jeffrey S Chamberlain and Glen B Banks

    Citation: Skeletal Muscle 2014 4:10

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