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  1. Content type: Research

    Presently, there is no effective treatment for the lethal muscle wasting disease Duchenne muscular dystrophy (DMD). Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the ...

    Authors: Nicholas Ieronimakis, Mario Pantoja, Aislinn L Hays, Timothy L Dosey, Junlin Qi, Karin A Fischer, Andrew N Hoofnagle, Martin Sadilek, Jeffrey S Chamberlain, Hannele Ruohola-Baker and Morayma Reyes

    Citation: Skeletal Muscle 2013 3:20

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  2. Content type: Methodology

    microRNA regulation plays an important role in the remodeling that occurs in response to pathologic and physiologic stimuli in skeletal muscle. In response to stress, microRNAs are dynamically regulated, resul...

    Authors: Martin G Guess, Kristen KB Barthel, Emily K Pugach and Leslie A Leinwand

    Citation: Skeletal Muscle 2013 3:19

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  3. Content type: Research

    Proinflammatory cytokine tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 are the major regulators of skeletal muscle mass in many catabolic conditions. However, their r...

    Authors: Shuichi Sato, Yuji Ogura, Vivek Mishra, Jonghyun Shin, Shephali Bhatnagar, Bradford G Hill and Ashok Kumar

    Citation: Skeletal Muscle 2013 3:18

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  4. Content type: Research

    Autosomal Emery-Dreifuss muscular dystrophy is caused by mutations in the lamin A/C gene (LMNA) encoding A-type nuclear lamins, intermediate filament proteins of the nuclear envelope. Classically, the disease man...

    Authors: Antoine Muchir, Young Jin Kim, Sarah A Reilly, Wei Wu, Jason C Choi and Howard J Worman

    Citation: Skeletal Muscle 2013 3:17

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  5. Content type: Research

    Cell growth and terminal differentiation are controlled by complex signaling systems that regulate the tissue-specific expression of genes controlling cell fate and morphogenesis. We have previously reported t...

    Authors: Christopher J Storbeck, Khalid N Al-Zahrani, Roshan Sriram, Sarah Kawesa, Paul O’Reilly, Kate Daniel, Marlene McKay, Rashmi Kothary, Catherine Tsilfidis and Luc A Sabourin

    Citation: Skeletal Muscle 2013 3:16

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  6. Content type: Research

    Duchenne muscular dystrophy (DMD) is one of the most frequent forms of muscular disorders. It is caused by the absence of dystrophin, a core component of the sarcolemma-associated junctional complex that links...

    Authors: Marianne Raith, Rocio G Valencia, Irmgard Fischer, Michael Orthofer, Josef M Penninger, Simone Spuler, Günther A Rezniczek and Gerhard Wiche

    Citation: Skeletal Muscle 2013 3:14

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  7. Content type: Research

    During the past decade, several animal studies have demonstrated that in addition to local cells, cells from the bone marrow (BM) possess the ability to contribute to regeneration of injured skeletal muscle ti...

    Authors: Anna Strömberg, Monika Jansson, Helene Fischer, Eric Rullman, Hans Hägglund and Thomas Gustafsson

    Citation: Skeletal Muscle 2013 3:12

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  8. Content type: Research

    A sophisticated level of coordinated gene expression is necessary for skeletal muscle fibers to obtain their unique functional identities. We have previously shown that the transcription factor Sox6 plays an e...

    Authors: Chung-Il An, Edward Ganio and Nobuko Hagiwara

    Citation: Skeletal Muscle 2013 3:11

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  9. Content type: Review

    Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy and an X-linked recessive, progressive muscle wasting disease caused by the absence of a functional dystrophin protein. Dystrophin has a ...

    Authors: James P Ennen, Mayank Verma and Atsushi Asakura

    Citation: Skeletal Muscle 2013 3:9

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  10. Content type: Research

    Transcription factor overexpression is common in biological experiments and transcription factor amplification is associated with many cancers, yet few studies have directly compared the DNA-binding profiles o...

    Authors: Zizhen Yao, Abraham P Fong, Yi Cao, Walter L Ruzzo, Robert C Gentleman and Stephen J Tapscott

    Citation: Skeletal Muscle 2013 3:8

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  11. Content type: Research

    Krüppel-like factor 6 (KLF6) has been recently identified as a MEF2D target gene involved in neuronal cell survival. In addition, KLF6 and TGFβ have been shown to regulate each other’s expression in non-myogen...

    Authors: Mathew G Dionyssiou, Jahan Salma, Mariya Bevzyuk, Stephanie Wales, Lusine Zakharyan and John C McDermott

    Citation: Skeletal Muscle 2013 3:7

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  12. Content type: Research

    Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicate...

    Authors: C Florian Bentzinger, Shuo Lin, Klaas Romanino, Perrine Castets, Maitea Guridi, Serge Summermatter, Christoph Handschin, Lionel A Tintignac, Michael N Hall and Markus A Rüegg

    Citation: Skeletal Muscle 2013 3:6

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  13. Content type: Research

    The clinical features of myofibrillar myopathies display a wide phenotypic heterogeneity. To this date, no studies have evaluated this parameter due to the absence of pertinent animal models. By studying two m...

    Authors: Pierre Joanne, Oussama Chourbagi, Christophe Hourdé, Arnaud Ferry, Gillian Butler-Browne, Patrick Vicart, Julie Dumonceaux and Onnik Agbulut

    Citation: Skeletal Muscle 2013 3:4

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  14. Content type: Research

    The complexity of the skeletal muscle and the identification of numerous human disease-causing mutations in its constitutive proteins make it an interesting tissue for proteomic studies aimed at understanding ...

    Authors: Gaëlle Blandin, Sylvie Marchand, Karine Charton, Nathalie Danièle, Evelyne Gicquel, Jean-Baptiste Boucheteil, Azéddine Bentaib, Laetitia Barrault, Daniel Stockholm, Marc Bartoli and Isabelle Richard

    Citation: Skeletal Muscle 2013 3:3

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  15. Content type: Review

    Satellite cells are rare mononuclear skeletal muscle-resident cells that are the chief contributors to regenerative myogenesis following muscle injury. Although first identified more than 50 years ago, it is o...

    Authors: Akshay Bareja and Andrew N Billin

    Citation: Skeletal Muscle 2013 3:2

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  16. Content type: Research

    Mice from the MRL or “superhealing” strain have enhanced repair after acute injury to the skin, cornea, and heart. We now tested an admixture of the MRL genome and found that it altered the course of muscle pa...

    Authors: Ahlke Heydemann, Kayleigh A Swaggart, Gene H Kim, Jenan Holley-Cuthrell, Michele Hadhazy and Elizabeth M McNally

    Citation: Skeletal Muscle 2012 2:26

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  17. Content type: Research

    Cell-transplantation therapies have attracted attention as treatments for skeletal-muscle disorders; however, such research has been severely limited by poor cell survival. Tissue engineering offers a potentia...

    Authors: Claudia Fuoco, Maria Lavinia Salvatori, Antonella Biondo, Keren Shapira-Schweitzer, Sabrina Santoleri, Stefania Antonini, Sergio Bernardini, Francesco Saverio Tedesco, Stefano Cannata, Dror Seliktar, Giulio Cossu and Cesare Gargioli

    Citation: Skeletal Muscle 2012 2:24

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  18. Content type: Review

    The family of mammalian sialidases is composed of four distinct versatile enzymes that remove negatively charged terminal sialic acid residues from gangliosides and glycoproteins in different subcellular areas...

    Authors: Alessandro Fanzani, Alessandra Zanola, Fiorella Faggi, Nadia Papini, Bruno Venerando, Guido Tettamanti, Maurilio Sampaolesi and Eugenio Monti

    Citation: Skeletal Muscle 2012 2:23

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  19. Content type: Research

    Satellite cells are resident skeletal muscle stem cells responsible for muscle maintenance and repair. In resting muscle, satellite cells are maintained in a quiescent state. Satellite cell activation induces ...

    Authors: Nicholas H Farina, Melissa Hausburg, NicoleDalla Betta, Crystal Pulliam, Deepak Srivastava, DDW Cornelison and Bradley B Olwin

    Citation: Skeletal Muscle 2012 2:21

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  20. Content type: Research

    Recycling of endosomes is important for trafficking and maintenance of proteins at the neuromuscular junction (NMJ). We have previously shown high expression of the endocytic recycling regulator Eps15 homology...

    Authors: Suzanne E Mate, Jack H Van Der Meulen, Priyanka Arya, Sohinee Bhattacharyya, Hamid Band and Eric P Hoffman

    Citation: Skeletal Muscle 2012 2:19

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  21. Content type: Research

    Laminin-α2-deficient congenital muscular dystrophy (MDC1A) is a severe muscle-wasting disease for which no curative treatment is available. Antagonists of the angiotensin II receptor type 1 (AT1), including th...

    Authors: Sarina Meinen, Shuo Lin and Markus A Ruegg

    Citation: Skeletal Muscle 2012 2:18

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  22. Content type: Research

    Duchenne muscular dystrophy is a genetic disease involving a severe muscle wasting that is characterized by cycles of muscle degeneration/regeneration and culminates in early death in affected boys. Mitochondr...

    Authors: Vanessa E Jahnke, Jack H Van Der Meulen, Helen K Johnston, Svetlana Ghimbovschi, Terrence Partridge, Eric P Hoffman and Kanneboyina Nagaraju

    Citation: Skeletal Muscle 2012 2:16

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  23. Content type: Research

    Insulin-like growth factor-1 (IGF-1) is the most important physiological regulator of skeletal muscle progenitor cells, which are responsible for adult skeletal muscle regeneration. The ability of IGF-1 to aff...

    Authors: Caterina Bernacchioni, Francesca Cencetti, Sabrina Blescia, Chiara Donati and Paola Bruni

    Citation: Skeletal Muscle 2012 2:15

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  24. Content type: Research

    Muscle protein turnover regulation during cancer cachexia is being rapidly defined, and skeletal muscle mitochondria function appears coupled to processes regulating muscle wasting. Skeletal muscle oxidative c...

    Authors: James P White, Melissa J Puppa, Shuichi Sato, Song Gao, Robert L Price, John W Baynes, Matthew C Kostek, Lydia E Matesic and James A Carson

    Citation: Skeletal Muscle 2012 2:14

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  25. Content type: Methodology

    Muscle growth and repair is accomplished by the satellite cell pool, a self-renewing population of myogenic progenitors. Functional heterogeneity within the satellite cell compartment and changes in potential ...

    Authors: Joseph Ippolito, Robert W Arpke, Kerri T Haider, Jianyi Zhang and Michael Kyba

    Citation: Skeletal Muscle 2012 2:13

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  26. Content type: Research

    Despite the success of highly active antiretroviral therapy (HAART), HIV infected individuals remain at increased risk for frailty and declines in physical function that are more often observed in older uninfe...

    Authors: Rebecca L Kusko, Camellia Banerjee, Kimberly K Long, Ariana Darcy, Jeffrey Otis, Paola Sebastiani, Simon Melov, Mark Tarnopolsky, Shalender Bhasin and Monty Montano

    Citation: Skeletal Muscle 2012 2:10

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  27. Content type: Research

    Disruption of the sarcolemma-associated dystrophin-glycoprotein complex underlies multiple forms of muscular dystrophy, including Duchenne muscular dystrophy and sarcoglycanopathies. A hallmark of these disord...

    Authors: Daniel C Andersson, Albano C Meli, Steven Reiken, Matthew J Betzenhauser, Alisa Umanskaya, Takayuki Shiomi, Jeanine D’Armiento and Andrew R Marks

    Citation: Skeletal Muscle 2012 2:9

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  28. Content type: Methodology

    The use of the Cre/loxP system for gene targeting has been proven to be a powerful tool for understanding gene function. The purpose of this study was to create and characterize an inducible, skeletal muscle-s...

    Authors: John J McCarthy, Ratchakrit Srikuea, Tyler J Kirby, Charlotte A Peterson and Karyn A Esser

    Citation: Skeletal Muscle 2012 2:8

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    The Erratum to this article has been published in Skeletal Muscle 2012 2:22

  29. Content type: Research

    Similar to replicating myoblasts, many rhabdomyosarcoma cells express the myogenic determination gene MyoD. In contrast to myoblasts, rhabdomyosarcoma cells do not make the transition from a regulative growth ...

    Authors: Kyle L MacQuarrie, Zizhen Yao, Janet M Young, Yi Cao and Stephen J Tapscott

    Citation: Skeletal Muscle 2012 2:7

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  30. Content type: Research

    Mice lacking MyoD exhibit delayed skeletal muscle regeneration and markedly enhanced numbers of satellite cells. Myoblasts isolated from MyoD -/- myoblasts proliferate more ...

    Authors: Maura H Parker, Julia von Maltzahn, Nadine Bakkar, Ban Al-Joubori, Jeff Ishibashi, Denis Guttridge and Michael A Rudnicki

    Citation: Skeletal Muscle 2012 2:6

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    The Retraction Note to this article has been published in Skeletal Muscle 2013 3:15

  31. Content type: Research

    The p38α mitogen-activated protein kinase (MAPK) is a critical mediator of myoblast differentiation, and does so in part through the phosphorylation and regulation of several transcription factors and chromati...

    Authors: James DR Knight, Ruijun Tian, Robin EC Lee, Fangjun Wang, Ariane Beauvais, Hanfa Zou, Lynn A Megeney, Anne-Claude Gingras, Tony Pawson, Daniel Figeys and Rashmi Kothary

    Citation: Skeletal Muscle 2012 2:5

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  32. Content type: Research

    Transplantation of myogenic stem cells possesses great potential for long-term repair of dystrophic muscle. In murine-to-murine transplantation experiments, CXCR4 expression marks a population of adult murine ...

    Authors: Maura H Parker, Carol Loretz, Ashlee E Tyler, Lauren Snider, Rainer Storb and Stephen J Tapscott

    Citation: Skeletal Muscle 2012 2:4

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  33. Content type: Research

    Skeletal-muscle differentiation is required for the regeneration of myofibers after injury. The differentiation capacity of satellite cells is impaired in settings of old age, which is at least one factor in t...

    Authors: Anne Ulrike Trendelenburg, Angelika Meyer, Carsten Jacobi, Jerome N Feige and David J Glass

    Citation: Skeletal Muscle 2012 2:3

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  34. Content type: Research

    Muscle atrophy associated with various pathophysiological conditions represents a major health problem, because of its contribution to the deterioration of patient status and its effect on mortality. Although ...

    Authors: Joffrey De Larichaudy, Alessandra Zufferli, Filippo Serra, Andrea M Isidori, Fabio Naro, Kevin Dessalle, Marine Desgeorges, Monique Piraud, David Cheillan, Hubert Vidal, Etienne Lefai and Georges Némoz

    Citation: Skeletal Muscle 2012 2:2

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  35. Content type: Research

    Myogenic differentiation involves cell-cycle arrest, activation of the muscle-specific transcriptome, and elongation, alignment and fusion of myoblasts into multinucleated myotubes. This process is controlled ...

    Authors: Annalisa Mancini, Dario Sirabella, Weijia Zhang, Hiroyuki Yamazaki, Tomoaki Shirao and Robert S Krauss

    Citation: Skeletal Muscle 2011 1:36

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  36. Content type: Research

    Investigations into both the pathophysiology and therapeutic targets in muscle dystrophies have been hampered by the limited proliferative capacity of human myoblasts. Isolation of reliable and stable immortal...

    Authors: Kamel Mamchaoui, Capucine Trollet, Anne Bigot, Elisa Negroni, Soraya Chaouch, Annie Wolff, Prashanth K Kandalla, Solenne Marie, James Di Santo, Jean Lacau St Guily, Francesco Muntoni, Jihee Kim, Susanne Philippi, Simone Spuler, Nicolas Levy, Sergiu C Blumen…

    Citation: Skeletal Muscle 2011 1:34

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