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  1. Content type: Research

    Despite the success of highly active antiretroviral therapy (HAART), HIV infected individuals remain at increased risk for frailty and declines in physical function that are more often observed in older uninfe...

    Authors: Rebecca L Kusko, Camellia Banerjee, Kimberly K Long, Ariana Darcy, Jeffrey Otis, Paola Sebastiani, Simon Melov, Mark Tarnopolsky, Shalender Bhasin and Monty Montano

    Citation: Skeletal Muscle 2012 2:10

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  2. Content type: Research

    Disruption of the sarcolemma-associated dystrophin-glycoprotein complex underlies multiple forms of muscular dystrophy, including Duchenne muscular dystrophy and sarcoglycanopathies. A hallmark of these disord...

    Authors: Daniel C Andersson, Albano C Meli, Steven Reiken, Matthew J Betzenhauser, Alisa Umanskaya, Takayuki Shiomi, Jeanine D’Armiento and Andrew R Marks

    Citation: Skeletal Muscle 2012 2:9

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  3. Content type: Methodology

    The use of the Cre/loxP system for gene targeting has been proven to be a powerful tool for understanding gene function. The purpose of this study was to create and characterize an inducible, skeletal muscle-s...

    Authors: John J McCarthy, Ratchakrit Srikuea, Tyler J Kirby, Charlotte A Peterson and Karyn A Esser

    Citation: Skeletal Muscle 2012 2:8

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    The Erratum to this article has been published in Skeletal Muscle 2012 2:22

  4. Content type: Research

    Similar to replicating myoblasts, many rhabdomyosarcoma cells express the myogenic determination gene MyoD. In contrast to myoblasts, rhabdomyosarcoma cells do not make the transition from a regulative growth ...

    Authors: Kyle L MacQuarrie, Zizhen Yao, Janet M Young, Yi Cao and Stephen J Tapscott

    Citation: Skeletal Muscle 2012 2:7

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  5. Content type: Research

    Mice lacking MyoD exhibit delayed skeletal muscle regeneration and markedly enhanced numbers of satellite cells. Myoblasts isolated from MyoD -/- myoblasts proliferate more ...

    Authors: Maura H Parker, Julia von Maltzahn, Nadine Bakkar, Ban Al-Joubori, Jeff Ishibashi, Denis Guttridge and Michael A Rudnicki

    Citation: Skeletal Muscle 2012 2:6

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    The Retraction Note to this article has been published in Skeletal Muscle 2013 3:15

  6. Content type: Research

    The p38α mitogen-activated protein kinase (MAPK) is a critical mediator of myoblast differentiation, and does so in part through the phosphorylation and regulation of several transcription factors and chromati...

    Authors: James DR Knight, Ruijun Tian, Robin EC Lee, Fangjun Wang, Ariane Beauvais, Hanfa Zou, Lynn A Megeney, Anne-Claude Gingras, Tony Pawson, Daniel Figeys and Rashmi Kothary

    Citation: Skeletal Muscle 2012 2:5

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  7. Content type: Research

    Transplantation of myogenic stem cells possesses great potential for long-term repair of dystrophic muscle. In murine-to-murine transplantation experiments, CXCR4 expression marks a population of adult murine ...

    Authors: Maura H Parker, Carol Loretz, Ashlee E Tyler, Lauren Snider, Rainer Storb and Stephen J Tapscott

    Citation: Skeletal Muscle 2012 2:4

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  8. Content type: Research

    Skeletal-muscle differentiation is required for the regeneration of myofibers after injury. The differentiation capacity of satellite cells is impaired in settings of old age, which is at least one factor in t...

    Authors: Anne Ulrike Trendelenburg, Angelika Meyer, Carsten Jacobi, Jerome N Feige and David J Glass

    Citation: Skeletal Muscle 2012 2:3

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  9. Content type: Research

    Muscle atrophy associated with various pathophysiological conditions represents a major health problem, because of its contribution to the deterioration of patient status and its effect on mortality. Although ...

    Authors: Joffrey De Larichaudy, Alessandra Zufferli, Filippo Serra, Andrea M Isidori, Fabio Naro, Kevin Dessalle, Marine Desgeorges, Monique Piraud, David Cheillan, Hubert Vidal, Etienne Lefai and Georges Némoz

    Citation: Skeletal Muscle 2012 2:2

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  10. Content type: Research

    Myogenic differentiation involves cell-cycle arrest, activation of the muscle-specific transcriptome, and elongation, alignment and fusion of myoblasts into multinucleated myotubes. This process is controlled ...

    Authors: Annalisa Mancini, Dario Sirabella, Weijia Zhang, Hiroyuki Yamazaki, Tomoaki Shirao and Robert S Krauss

    Citation: Skeletal Muscle 2011 1:36

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  11. Content type: Research

    Investigations into both the pathophysiology and therapeutic targets in muscle dystrophies have been hampered by the limited proliferative capacity of human myoblasts. Isolation of reliable and stable immortal...

    Authors: Kamel Mamchaoui, Capucine Trollet, Anne Bigot, Elisa Negroni, Soraya Chaouch, Annie Wolff, Prashanth K Kandalla, Solenne Marie, James Di Santo, Jean Lacau St Guily, Francesco Muntoni, Jihee Kim, Susanne Philippi, Simone Spuler, Nicolas Levy, Sergiu C Blumen…

    Citation: Skeletal Muscle 2011 1:34

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  12. Content type: Research

    γ-cytoplasmic (γ-cyto) actin levels are elevated in dystrophin-deficient mdx mouse skeletal muscle. The purpose of this study was to determine whether further elevation of γ-cyto actin levels improve or exacerbat...

    Authors: Kristen A Baltgalvis, Michele A Jaeger, Daniel P Fitzsimons, Stanley A Thayer, Dawn A Lowe and James M Ervasti

    Citation: Skeletal Muscle 2011 1:32

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  13. Content type: Research

    The balance between muscle regeneration and ongoing degeneration is a relationship that greatly influences the progression of muscular dystrophy. Numerous factors may influence the muscle regeneration, but mor...

    Authors: Thomas O Krag, Simon Hauerslev, Marie Louise Sveen, Malene Schwartz and John Vissing

    Citation: Skeletal Muscle 2011 1:31

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  14. Content type: Review

    Collagen VI myopathies, caused by mutations in the genes encoding collagen type VI (ColVI), represent a clinical continuum with Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM) at each en...

    Authors: Valérie Allamand, Laura Briñas, Pascale Richard, Tanya Stojkovic, Susana Quijano-Roy and Gisèle Bonne

    Citation: Skeletal Muscle 2011 1:30

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  15. Content type: Review

    In February 1961, Alexander Mauro described a cell 'wedged' between the plasma membrane of the muscle fibre and the surrounding basement membrane. He postulated that it could be a dormant myoblast, poised to r...

    Authors: Juergen Scharner and Peter S Zammit

    Citation: Skeletal Muscle 2011 1:28

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  16. Content type: Research

    Duchenne muscular dystrophy (DMD) is an X-linked myopathy resulting from the production of a nonfunctional dystrophin protein. MicroRNA (miRNA) are small 21- to 24-nucleotide RNA that can regulate both individ...

    Authors: Matthew S Alexander, Juan Carlos Casar, Norio Motohashi, Jennifer A Myers, Iris Eisenberg, Robert T Gonzalez, Elicia A Estrella, Peter B Kang, Genri Kawahara and Louis M Kunkel

    Citation: Skeletal Muscle 2011 1:27

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  17. Content type: Research

    Hundreds of genes, including muscle creatine kinase (MCK), are differentially expressed in fast- and slow-twitch muscle fibers, but the fiber type-specific regulatory mechanisms are not well understood.

    Authors: Phillip WL Tai, Katherine I Fisher-Aylor, Charis L Himeda, Catherine L Smith, Alexandra P MacKenzie, Deri L Helterline, John C Angello, Robert E Welikson, Barbara J Wold and Stephen D Hauschka

    Citation: Skeletal Muscle 2011 1:25

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  18. Content type: Research

    Nemaline myopathy (NM) is a congenital muscle disease associated with weakness and the presence of nemaline bodies (rods) in muscle fibers. Mutations in seven genes have been associated with NM, but the most c...

    Authors: Michael W Lawlor, Coen A Ottenheijm, Vilma-Lotta Lehtokari, Kiyomi Cho, Katarina Pelin, Carina Wallgren-Pettersson, Henk Granzier and Alan H Beggs

    Citation: Skeletal Muscle 2011 1:23

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  19. Content type: Review

    The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resi...

    Authors: Christopher J Mann, Eusebio Perdiguero, Yacine Kharraz, Susana Aguilar, Patrizia Pessina, Antonio L Serrano and Pura Muñoz-Cánoves

    Citation: Skeletal Muscle 2011 1:21

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  20. Content type: Research

    During development, the branchial mesoderm of Torpedo californica transdifferentiates into an electric organ capable of generating high voltage discharges to stun fish. The organ contains a high density of cholin...

    Authors: Suzanne E. Mate, Kristy J. Brown and Eric P. Hoffman

    Citation: Skeletal Muscle 2011 1:20

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  21. Content type: Review

    Excitation-contraction coupling involves the faithful conversion of electrical stimuli to mechanical shortening in striated muscle cells, enabled by the ubiquitous second messenger, calcium. Crucial to this pr...

    Authors: EMichelle Capes, Randall Loaiza and Héctor H Valdivia

    Citation: Skeletal Muscle 2011 1:18

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  22. Content type: Research

    Leukemia inhibitory factor (LIF) is known to inhibit myogenic differentiation as well as to inhibit apoptosis and caspase-3 activation in non-differentiating myoblasts. In addition caspase-3 activity is requir...

    Authors: Liam C Hunt, Aradhana Upadhyay, Jalal A Jazayeri, Elizabeth M Tudor and Jason D White

    Citation: Skeletal Muscle 2011 1:17

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  23. Content type: Review

    Stromal interaction molecules (STIM) were identified as the endoplasmic-reticulum (ER) Ca2+ sensor controlling store-operated Ca2+ entry (SOCE) and Ca2+-release-activated Ca2+ (CRAC) channels in non-excitable cel...

    Authors: Santeri Kiviluoto, Jean-Paul Decuypere, Humbert De Smedt, Ludwig Missiaen, Jan B. Parys and Geert Bultynck

    Citation: Skeletal Muscle 2011 1:16

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  24. Content type: Research

    Oculopharyngeal muscular dystrophy (OPMD) is a late-onset progressive muscle disorder caused by a poly-alanine expansion mutation in the Poly(A) Binding Protein Nuclear 1 (PABPN1). The molecular mechanisms tha...

    Authors: Seyed Yahya Anvar, Peter A. C. 't Hoen, Andrea Venema, Barbara van der Sluijs, Baziel van Engelen, Marc Snoeck, John Vissing, Capucine Trollet, George Dickson, Aymeric Chartier, Martine Simonelig, Gert-Jan B. van Ommen, Silvere M. van der Maarel and Vered Raz

    Citation: Skeletal Muscle 2011 1:15

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  25. Content type: Research

    A hallmark of muscular dystrophies is the replacement of muscle by connective tissue. Muscle biopsies from patients severely affected with facioscapulohumeral muscular dystrophy (FSHD) may contain few myogenic...

    Authors: Guido Stadler, Jennifer CJ Chen, Kathryn Wagner, Jerome D Robin, Jerry W Shay, Charles P Emerson Jr. Jr and Woodring E Wright

    Citation: Skeletal Muscle 2011 1:12

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  26. Content type: Research

    Sarcopenia, the loss of skeletal muscle mass during aging, increases the risk for falls and dependency. Resistance exercise (RE) training is an effective treatment to improve muscle mass and strength in older ...

    Authors: Christopher S Fry, Micah J Drummond, Erin L Glynn, Jared M Dickinson, David M Gundermann, Kyle L Timmerman, Dillon K Walker, Shaheen Dhanani, Elena Volpi and Blake B Rasmussen

    Citation: Skeletal Muscle 2011 1:11

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  27. Content type: Research

    The most remarkable feature of skeletal muscle is the capacity to adapt its morphological, biochemical and molecular properties in response to several factors. Nonetheless, under pathological conditions, skele...

    Authors: Gabriella Dobrowolny, Michela Aucello and Antonio Musarò

    Citation: Skeletal Muscle 2011 1:3

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  28. Content type: Commentary

    Skeletal muscle wasting is a major component of cachectic states found in a variety of disease settings, including cancer. As increasing caloric intake often provides little benefit in combating muscle loss in...

    Authors: Se-Jin Lee and David J Glass

    Citation: Skeletal Muscle 2011 1:2

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