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  1. Content type: Research

    γ-cytoplasmic (γ-cyto) actin levels are elevated in dystrophin-deficient mdx mouse skeletal muscle. The purpose of this study was to determine whether further elevation of γ-cyto actin levels improve or exacerbat...

    Authors: Kristen A Baltgalvis, Michele A Jaeger, Daniel P Fitzsimons, Stanley A Thayer, Dawn A Lowe and James M Ervasti

    Citation: Skeletal Muscle 2011 1:32

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  2. Content type: Research

    The balance between muscle regeneration and ongoing degeneration is a relationship that greatly influences the progression of muscular dystrophy. Numerous factors may influence the muscle regeneration, but mor...

    Authors: Thomas O Krag, Simon Hauerslev, Marie Louise Sveen, Malene Schwartz and John Vissing

    Citation: Skeletal Muscle 2011 1:31

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  3. Content type: Review

    Collagen VI myopathies, caused by mutations in the genes encoding collagen type VI (ColVI), represent a clinical continuum with Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM) at each en...

    Authors: Valérie Allamand, Laura Briñas, Pascale Richard, Tanya Stojkovic, Susana Quijano-Roy and Gisèle Bonne

    Citation: Skeletal Muscle 2011 1:30

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  4. Content type: Review

    In February 1961, Alexander Mauro described a cell 'wedged' between the plasma membrane of the muscle fibre and the surrounding basement membrane. He postulated that it could be a dormant myoblast, poised to r...

    Authors: Juergen Scharner and Peter S Zammit

    Citation: Skeletal Muscle 2011 1:28

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  5. Content type: Research

    Duchenne muscular dystrophy (DMD) is an X-linked myopathy resulting from the production of a nonfunctional dystrophin protein. MicroRNA (miRNA) are small 21- to 24-nucleotide RNA that can regulate both individ...

    Authors: Matthew S Alexander, Juan Carlos Casar, Norio Motohashi, Jennifer A Myers, Iris Eisenberg, Robert T Gonzalez, Elicia A Estrella, Peter B Kang, Genri Kawahara and Louis M Kunkel

    Citation: Skeletal Muscle 2011 1:27

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  6. Content type: Research

    Hundreds of genes, including muscle creatine kinase (MCK), are differentially expressed in fast- and slow-twitch muscle fibers, but the fiber type-specific regulatory mechanisms are not well understood.

    Authors: Phillip WL Tai, Katherine I Fisher-Aylor, Charis L Himeda, Catherine L Smith, Alexandra P MacKenzie, Deri L Helterline, John C Angello, Robert E Welikson, Barbara J Wold and Stephen D Hauschka

    Citation: Skeletal Muscle 2011 1:25

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  7. Content type: Research

    Nemaline myopathy (NM) is a congenital muscle disease associated with weakness and the presence of nemaline bodies (rods) in muscle fibers. Mutations in seven genes have been associated with NM, but the most c...

    Authors: Michael W Lawlor, Coen A Ottenheijm, Vilma-Lotta Lehtokari, Kiyomi Cho, Katarina Pelin, Carina Wallgren-Pettersson, Henk Granzier and Alan H Beggs

    Citation: Skeletal Muscle 2011 1:23

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  8. Content type: Review

    The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resi...

    Authors: Christopher J Mann, Eusebio Perdiguero, Yacine Kharraz, Susana Aguilar, Patrizia Pessina, Antonio L Serrano and Pura Muñoz-Cánoves

    Citation: Skeletal Muscle 2011 1:21

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  9. Content type: Research

    During development, the branchial mesoderm of Torpedo californica transdifferentiates into an electric organ capable of generating high voltage discharges to stun fish. The organ contains a high density of cholin...

    Authors: Suzanne E. Mate, Kristy J. Brown and Eric P. Hoffman

    Citation: Skeletal Muscle 2011 1:20

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  10. Content type: Review

    Excitation-contraction coupling involves the faithful conversion of electrical stimuli to mechanical shortening in striated muscle cells, enabled by the ubiquitous second messenger, calcium. Crucial to this pr...

    Authors: EMichelle Capes, Randall Loaiza and Héctor H Valdivia

    Citation: Skeletal Muscle 2011 1:18

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  11. Content type: Research

    Leukemia inhibitory factor (LIF) is known to inhibit myogenic differentiation as well as to inhibit apoptosis and caspase-3 activation in non-differentiating myoblasts. In addition caspase-3 activity is requir...

    Authors: Liam C Hunt, Aradhana Upadhyay, Jalal A Jazayeri, Elizabeth M Tudor and Jason D White

    Citation: Skeletal Muscle 2011 1:17

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  12. Content type: Review

    Stromal interaction molecules (STIM) were identified as the endoplasmic-reticulum (ER) Ca2+ sensor controlling store-operated Ca2+ entry (SOCE) and Ca2+-release-activated Ca2+ (CRAC) channels in non-excitable cel...

    Authors: Santeri Kiviluoto, Jean-Paul Decuypere, Humbert De Smedt, Ludwig Missiaen, Jan B. Parys and Geert Bultynck

    Citation: Skeletal Muscle 2011 1:16

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  13. Content type: Research

    Oculopharyngeal muscular dystrophy (OPMD) is a late-onset progressive muscle disorder caused by a poly-alanine expansion mutation in the Poly(A) Binding Protein Nuclear 1 (PABPN1). The molecular mechanisms tha...

    Authors: Seyed Yahya Anvar, Peter A. C. 't Hoen, Andrea Venema, Barbara van der Sluijs, Baziel van Engelen, Marc Snoeck, John Vissing, Capucine Trollet, George Dickson, Aymeric Chartier, Martine Simonelig, Gert-Jan B. van Ommen, Silvere M. van der Maarel and Vered Raz

    Citation: Skeletal Muscle 2011 1:15

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  14. Content type: Research

    A hallmark of muscular dystrophies is the replacement of muscle by connective tissue. Muscle biopsies from patients severely affected with facioscapulohumeral muscular dystrophy (FSHD) may contain few myogenic...

    Authors: Guido Stadler, Jennifer CJ Chen, Kathryn Wagner, Jerome D Robin, Jerry W Shay, Charles P Emerson Jr. Jr and Woodring E Wright

    Citation: Skeletal Muscle 2011 1:12

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  15. Content type: Research

    Sarcopenia, the loss of skeletal muscle mass during aging, increases the risk for falls and dependency. Resistance exercise (RE) training is an effective treatment to improve muscle mass and strength in older ...

    Authors: Christopher S Fry, Micah J Drummond, Erin L Glynn, Jared M Dickinson, David M Gundermann, Kyle L Timmerman, Dillon K Walker, Shaheen Dhanani, Elena Volpi and Blake B Rasmussen

    Citation: Skeletal Muscle 2011 1:11

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  16. Content type: Research

    The most remarkable feature of skeletal muscle is the capacity to adapt its morphological, biochemical and molecular properties in response to several factors. Nonetheless, under pathological conditions, skele...

    Authors: Gabriella Dobrowolny, Michela Aucello and Antonio Musarò

    Citation: Skeletal Muscle 2011 1:3

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  17. Content type: Commentary

    Skeletal muscle wasting is a major component of cachectic states found in a variety of disease settings, including cancer. As increasing caloric intake often provides little benefit in combating muscle loss in...

    Authors: Se-Jin Lee and David J Glass

    Citation: Skeletal Muscle 2011 1:2

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