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Table 1 Deregulation of ubiquitin-proteasome system (UPS) in OPMD in Drosophila, human and mouse.

From: Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients

  Drosophila a Mouse Human
Literature Analysis    
   Ubiquitination # 2 # 1 # 1
GO Categories    
   Ubiquitin-dependent Protein Catabolic Process 2.81E-04 2.27E-07 1.22E-03
   Protein Ubiquitination 7.57E-03 1.88E-05 9.24E-04
   Proteasomal Protein Catabolic Process 6.51E-03 2.23E-07 1.86E-03
   Ubiquitin Mediated Proteolysis 2.03E-03 8.25E-08 1.52E-03
   Proteasome 2.15E-04 1.37E-07 9.27E-03
  1. For Drosophila and mouse P-values are derived from the combined analysis of the three time points using global test, where age was included as a confounder in the model.