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  1. Human iPSC-derived 3D-tissue-engineered-skeletal muscles (3D-TESMs) offer advanced technology for disease modelling. However, due to the inherent genetic heterogeneity among human individuals, it is often diff...

    Authors: Stijn L. M. in ‘t Groen, Marnix Franken, Theresa Bock, Marcus Krüger, Jessica C. de Greef and W. W. M. Pim Pijnappel
    Citation: Skeletal Muscle 2024 14:3
  2. Multiple clinical trials to assess the efficacy of AAV-directed gene transfer in participants with Duchenne muscular dystrophy (DMD) are ongoing. The success of these trials currently relies on standard functi...

    Authors: Jessica F. Boehler, Kristy J. Brown, Valeria Ricotti and Carl A. Morris
    Citation: Skeletal Muscle 2024 14:2
  3. Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogenetic protein) co-receptor that promotes and shapes BMP signaling. MuSK is expressed at ...

    Authors: Diego Jaime, Lauren A. Fish, Laura A. Madigan, Chengjie Xi, Giorgia Piccoli, Madison D. Ewing, Bert Blaauw and Justin R. Fallon
    Citation: Skeletal Muscle 2024 14:1
  4. Cross-sectional studies have demonstrated the association of skeletal muscle mass with metabolic-associated fatty liver disease (MAFLD), while longitudinal data are scarce. We aimed to explore the impact of ch...

    Authors: Ting Zhou, Junzhao Ye, Ling Luo, Wei Wang, Shiting Feng, Zhi Dong, Shuyu Zhuo and Bihui Zhong
    Citation: Skeletal Muscle 2023 13:23
  5. We investigated the effect of eldecalcitol on disuse muscle atrophy. C57BL/6J male mice aged 6 weeks were randomly assigned to control, tail suspension (TS), and TS-eldecalcitol–treated groups and were injecte...

    Authors: Haichao Zhang, Yanping Du, Wenjing Tang, Minmin Chen, Weijia Yu, Zheng Ke, Shuangshuang Dong and Qun Cheng
    Citation: Skeletal Muscle 2023 13:22
  6. Hypoxia is known to modify skeletal muscle biological functions and muscle regeneration. However, the mechanisms underlying the effects of hypoxia on human myoblast differentiation remain unclear. The hypoxic ...

    Authors: Thuy-Hang Nguyen, Lise Paprzycki, Alexandre Legrand, Anne-Emilie Declèves, Philipp Heher, Maelle Limpens, Alexandra Belayew, Christopher R. S. Banerji, Peter S. Zammit and Alexandra Tassin
    Citation: Skeletal Muscle 2023 13:21
  7. Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in DMD gene and loss of the protein dystrophin, which ultimately leads to myofiber membrane fragility and necrosis, with eventual muscl...

    Authors: Déborah Cardoso, Inès Barthélémy, Stéphane Blot and Antoine Muchir
    Citation: Skeletal Muscle 2023 13:20
  8. The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle inflammation and degeneration. Therefore, the restoration of functional dystrophin levels is a fund...

    Authors: Tetsuaki Hiyoshi, Fuqiang Zhao, Rina Baba, Takeshi Hirakawa, Ryosuke Kuboki, Kazunori Suzuki, Yoshiro Tomimatsu, Patricio O’Donnell, Steve Han, Neta Zach and Masato Nakashima
    Citation: Skeletal Muscle 2023 13:19
  9. While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for glucose clearance, have yet to be elucidated in older in...

    Authors: Mark A. Burton, Emma S. Garratt, Matthew O. Hewitt, Hanan Y. Sharkh, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Julia L. MacIsaac, Michael S. Kobor, Harnish P. Patel, Keith M. Godfrey and Karen A. Lillycrop
    Citation: Skeletal Muscle 2023 13:17
  10. Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy without an effective treatment, caused by mutations in the DMD gene, leading to the absence of dystrophin. DMD results in muscle weakness, ...

    Authors: Marcelo dos Santos Voltani Lorena, Estela Kato dos Santos, Renato Ferretti, G. A. Nagana Gowda, Guy L. Odom, Jeffrey S. Chamberlain and Cintia Yuri Matsumura
    Citation: Skeletal Muscle 2023 13:16
  11. Transcription factors (TFs) play key roles in regulating differentiation and function of stem cells, including muscle satellite cells (MuSCs), a resident stem cell population responsible for postnatal regenera...

    Authors: Stephanie N. Oprescu, Nick Baumann, Xiyue Chen, Qiang Sun, Yu Zhao, Feng Yue, Huating Wang and Shihuan Kuang
    Citation: Skeletal Muscle 2023 13:15
  12. Histological analysis of skeletal muscle is of major interest for understanding its behavior in different pathophysiological conditions, such as the response to different environments or myopathies. In this co...

    Authors: Anne Danckaert, Aurélie Trignol, Guillaume Le Loher, Sébastien Loubens, Bart Staels, Hélène Duez, Spencer L. Shorte and Alicia Mayeuf-Louchart
    Citation: Skeletal Muscle 2023 13:14
  13. The occurrence of hyperplasia, through myofibre splitting, remains a widely debated phenomenon. Structural alterations and fibre typing of skeletal muscle fibres, as seen during regeneration and in certain mus...

    Authors: Grith Højfeldt, Trent Sorenson, Alana Gonzales, Michael Kjaer, Jesper L. Andersen and Abigail L. Mackey
    Citation: Skeletal Muscle 2023 13:13
  14. Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to rise during critical illness. FGF21 is a pleiotropic hormone that mediates adaptive respo...

    Authors: Wouter Vankrunkelsven, Steven Thiessen, Sarah Derde, Ellen Vervoort, Inge Derese, Isabel Pintelon, Hanne Matheussen, Alexander Jans, Chloë Goossens, Lies Langouche, Greet Van den Berghe and Ilse Vanhorebeek
    Citation: Skeletal Muscle 2023 13:12
  15. As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakness is known as “sarcopenia”. Sarcopenia is part of the frailty observed in humans. In ...

    Authors: Tea Shavlakadze, Kun Xiong, Shawn Mishra, Corissa McEwen, Abhilash Gadi, Matthew Wakai, Hunter Salmon, Michael J. Stec, Nicole Negron, Min Ni, Yi Wei, Gurinder S. Atwal, Yu Bai and David J. Glass
    Citation: Skeletal Muscle 2023 13:11
  16. Limb-girdle muscular dystrophy R8 (LGMD R8) is a rare autosomal recessive muscle disease caused by TRIM32 gene biallelic defects. The genotype–phenotype correlation of this disease has been reported poorly. He...

    Authors: Yuqing Guan, Xiongda Liang, Wei Li, Wanying Lin, Guanxia Liang, Hongting Xie, Yu Hou, Yafang Hu and Xuan Shang
    Citation: Skeletal Muscle 2023 13:10
  17. Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural integrity of the muscle cell membrane. DMD patients develop severe...

    Authors: Dongwoo Hahn, Joseph D. Quick, Brian R. Thompson, Adelyn Crabtree, Benjamin J. Hackel, Frank S. Bates and Joseph M. Metzger
    Citation: Skeletal Muscle 2023 13:9
  18. The functional and metabolic properties of skeletal muscles are partly a function of the spatial arrangement of fibers across the muscle belly. Many muscles feature a non-uniform spatial pattern of fiber types...

    Authors: Anna K. Redmond, Tilman M. Davies, Matthew R. Schofield and Philip W. Sheard
    Citation: Skeletal Muscle 2023 13:7
  19. Skeletal muscle (SkM) is a large, secretory organ that produces and releases myokines that can have autocrine, paracrine, and endocrine effects. Whether extracellular vesicles (EVs) also play a role in the SkM...

    Authors: Ahmed Ismaeel, Douglas W. Van Pelt, Zachary R. Hettinger, Xu Fu, Christopher I. Richards, Timothy A. Butterfield, Jonathan J. Petrocelli, Ivan J. Vechetti, Amy L. Confides, Micah J. Drummond and Esther E. Dupont-Versteegden
    Citation: Skeletal Muscle 2023 13:6
  20.  We have previously demonstrated that double homeobox 4 centromeric (DUX4C) encoded for a functional DUX4c protein upregulated in dystrophic skeletal muscles. Based on gain- and loss-of-function studies we have p...

    Authors: Clothilde Claus, Moriya Slavin, Eugénie Ansseau, Céline Lancelot, Karimatou Bah, Saskia Lassche, Manon Fiévet, Anna Greco, Sara Tomaiuolo, Alexandra Tassin, Virginie Dudome, Benno Kusters, Anne-Emilie Declèves, Dalila Laoudj-Chenivesse, Baziel G. M. van Engelen, Denis Nonclercq…
    Citation: Skeletal Muscle 2023 13:5
  21. The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this tissue is generally well studied and characterized, and many pathways have been elucidated throughout...

    Authors: Anna L. Schorr, Alejandro Felix Mejia, Martina Y. Miranda and Marco Mangone
    Citation: Skeletal Muscle 2023 13:4
  22. Sarcopenia is one of the most predominant musculoskeletal diseases of the elderly, defined as age-related progressive and generalized loss of muscle mass with a simultaneous reduction in muscle strength and/or...

    Authors: Jair Marques, Engy Shokry, Olaf Uhl, Lisa Baber, Fabian Hofmeister, Stefanie Jarmusch, Martin Bidlingmaier, Uta Ferrari, Berthold Koletzko and Michael Drey
    Citation: Skeletal Muscle 2023 13:2
  23. The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabi...

    Authors: Jackie L. McCourt, Kristen M. Stearns-Reider, Hafsa Mamsa, Pranav Kannan, Mohammad Hossein Afsharinia, Cynthia Shu, Elizabeth M. Gibbs, Kara M. Shin, Yerbol Z. Kurmangaliyev, Lauren R. Schmitt, Kirk C. Hansen and Rachelle H. Crosbie
    Citation: Skeletal Muscle 2023 13:1
  24. Sarcopenia is defined as age-related low muscle mass and function, and can also describe the loss of muscle mass in certain medical conditions, such as sarcopenic obesity. Sarcopenic obesity describes loss of ...

    Authors: Dana J. Murdock, Ning Wu, Joseph S. Grimsby, Roberto A. Calle, Stephen Donahue, David J. Glass, Mark W. Sleeman and Robert J. Sanchez
    Citation: Skeletal Muscle 2022 12:26
  25. Limb-girdle muscular dystrophy (MD) type 2B (LGMD2B) and Duchenne MD (DMD) are caused by mutations to the Dysferlin and Dystrophin genes, respectively. We have recently demonstrated in typically mild dysferlin...

    Authors: Zoe White, Zeren Sun, Elodie Sauge, Dan Cox, Graham Donen, Dmitri Pechkovsky, Volker Straub, Gordon A. Francis and Pascal Bernatchez
    Citation: Skeletal Muscle 2022 12:25
  26. Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes the plasma membrane of myofibers. The orofacial function is affected in an advanced sta...

    Authors: Keitaro Yamanouchi, Yukie Tanaka, Masanari Ikeda, Shizuka Kato, Ryosuke Okino, Hiroki Nishi, Fumihiko Hakuno, Shin-Ichiro Takahashi, James Chambers, Takashi Matsuwaki and Kazuyuki Uchida
    Citation: Skeletal Muscle 2022 12:24
  27. Choline kinase beta (CHKB) catalyzes the first step in the de novo biosynthesis of phosphatidyl choline and phosphatidylethanolamine via the Kennedy pathway. Derangement of this pathway might also influence th...

    Authors: Francesca Magri, Sara Antognozzi, Michela Ripolone, Simona Zanotti, Laura Napoli, Patrizia Ciscato, Daniele Velardo, Giulietta Scuvera, Valeria Nicotra, Antonella Giacobbe, Donatella Milani, Francesco Fortunato, Manuela Garbellini, Monica Sciacco, Stefania Corti, Giacomo Pietro Comi…
    Citation: Skeletal Muscle 2022 12:23
  28. In intensive care units (ICU), mechanical ventilation (MV) is commonly applied to save patients’ lives. However, ventilator-induced diaphragm dysfunction (VIDD) can complicate treatment by hindering weaning in...

    Authors: Dong Zhang, Wenyan Hao, Qi Niu, Dongdong Xu and Xuejiao Duan
    Citation: Skeletal Muscle 2022 12:21
  29. The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in adult muscle satellite cells (SCs) within hours following muscle damage and is required for effective stem cell activation and musc...

    Authors: A. Rasim Barutcu, Gabriel Elizalde, Alfredo E. Gonzalez, Kartik Soni, John L. Rinn, Amy J. Wagers and Albert E. Almada
    Citation: Skeletal Muscle 2022 12:20
  30. Progerin elevates atrophic gene expression and helps modify the nuclear membrane to cause severe muscle pathology, which is similar to muscle weakness in the elderly, to alter the development and function of t...

    Authors: Yaoxian Xiang, Zongqi You, Xinying Huang, Junxi Dai, Junpeng Zhang, Shuqi Nie, Lei Xu, Junjian Jiang and Jianguang Xu
    Citation: Skeletal Muscle 2022 12:19
  31. Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN) protein. SMA is characterized by the selective death of spinal cord motor neurons, lea...

    Authors: Katharina E. Meijboom, Emma R. Sutton, Eve McCallion, Emily McFall, Daniel Anthony, Benjamin Edwards, Sabrina Kubinski, Ines Tapken, Ines Bünermann, Gareth Hazell, Nina Ahlskog, Peter Claus, Kay E. Davies, Rashmi Kothary, Matthew J. A. Wood and Melissa Bowerman
    Citation: Skeletal Muscle 2022 12:18
  32. Skeletal muscle fiber type distribution has implications for human health, muscle function, and performance. This knowledge has been gathered using labor-intensive and costly methodology that limited these stu...

    Authors: Nikolay Oskolkov, Malgorzata Santel, Hemang M. Parikh, Ola Ekström, Gray J. Camp, Eri Miyamoto-Mikami, Kristoffer Ström, Bilal Ahmad Mir, Dmytro Kryvokhyzha, Mikko Lehtovirta, Hiroyuki Kobayashi, Ryo Kakigi, Hisashi Naito, Karl-Fredrik Eriksson, Björn Nystedt, Noriyuki Fuku…
    Citation: Skeletal Muscle 2022 12:16
  33. A common polymorphism (R577X) in the ACTN3 gene results in the complete absence of the Z-disc protein α-actinin-3 from fast-twitch muscle fibres in ~ 16% of the world’s population. This single gene polymorphism h...

    Authors: Michael Haug, Barbara Reischl, Stefanie Nübler, Leonit Kiriaev, Davi A. G. Mázala, Peter J. Houweling, Kathryn N. North, Oliver Friedrich and Stewart I. Head
    Citation: Skeletal Muscle 2022 12:14
  34. Aging decreases skeletal muscle mass and quality. Maintenance of healthy muscle is regulated by a balance between protein and organellar synthesis and their degradation. The autophagy-lysosome system is respon...

    Authors: Matthew Triolo, Ashley N. Oliveira, Rita Kumari and David A. Hood
    Citation: Skeletal Muscle 2022 12:13
  35. The analysis of in vitro cultures of human adult muscle stem cells obtained from biopsies delineates the potential of skeletal muscles and may help to understand altered muscle morphology in patients. In these...

    Authors: Simon Noë, Marlies Corvelyn, Sarah Willems, Domiziana Costamagna, Jean-Marie Aerts, Anja Van Campenhout and Kaat Desloovere
    Citation: Skeletal Muscle 2022 12:12
  36. As the interest in manned spaceflight increases, so does the requirement to understand the transcriptomic mechanisms that underlay the detrimental physiological adaptations of skeletal muscle to microgravity. ...

    Authors: Mason Henrich, Pin Ha, Yuanyuan Wang, Kang Ting, Louis Stodieck, Chia Soo, John S. Adams and Rene Chun
    Citation: Skeletal Muscle 2022 12:11
  37. Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increases the risk of mortality. Growth differentiation factor 11 (GDF11), centrally involved...

    Authors: Guiling Xiang, Kelu Ying, Pan Jiang, Mengping Jia, Yipeng Sun, Shanqun Li, Xiaodan Wu and Shengyu Hao
    Citation: Skeletal Muscle 2022 12:10
  38. Radiotherapy is commonly used to treat childhood cancers and can have adverse effects on muscle function, but the underlying mechanisms have yet to be fully elucidated. We hypothesized that endurance exercise ...

    Authors: Thomas N. O’Connor, Jacob G. Kallenbach, Haley M. Orciuoli, Nicole D. Paris, John F. Bachman, Carl J. Johnston, Eric Hernady, Jacqueline P. Williams, Robert T. Dirksen and Joe V. Chakkalakal
    Citation: Skeletal Muscle 2022 12:8
  39. Myostatin (MSTN) is a transforming growth factor-ß superfamily member that acts as a major regulator of skeletal muscle mass. GDF-11, which is highly related to MSTN, plays multiple roles during embryonic deve...

    Authors: Se-Jin Lee, Adam Lehar, Renata Rydzik, Daniel W. Youngstrom, Shalender Bhasin, Yewei Liu and Emily L. Germain-Lee
    Citation: Skeletal Muscle 2022 12:7
  40. Obstructive sleep apnea (OSA) imposes vascular and metabolic risks through chronic intermittent hypoxia (CIH) and impairs skeletal muscle performance. As studies addressing limb muscles are rare, the reasons f...

    Authors: L. I. Bannow, G. A. Bonaterra, M. Bertoune, S. Maus, R. Schulz, N. Weissmann, S. Kraut, R. Kinscherf and W. Hildebrandt
    Citation: Skeletal Muscle 2022 12:6
  41. Skeletal muscles are essential components of the neuromuscular skeletal system that have an integral role in the structure and function of the synovial joints which are often affected by osteoarthritis (OA). T...

    Authors: Salem Werdyani, Dawn Aitken, Zhiwei Gao, Ming Liu, Edward W. Randell, Proton Rahman, Graeme Jones and Guangju Zhai
    Citation: Skeletal Muscle 2022 12:4
  42. Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The efficiency of this process declines with age contributing to neuromuscular deficits. This study investigated...

    Authors: C. A. Staunton, E. D. Owen, K. Hemmings, A. Vasilaki, A. McArdle, R. Barrett-Jolley and M. J. Jackson
    Citation: Skeletal Muscle 2022 12:3

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