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Articles
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Citation: Skeletal Muscle 2022 12:15
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Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics
A common polymorphism (R577X) in the ACTN3 gene results in the complete absence of the Z-disc protein α-actinin-3 from fast-twitch muscle fibres in ~ 16% of the world’s population. This single gene polymorphism h...
Citation: Skeletal Muscle 2022 12:14 -
The influence of age, sex, and exercise on autophagy, mitophagy, and lysosome biogenesis in skeletal muscle
Aging decreases skeletal muscle mass and quality. Maintenance of healthy muscle is regulated by a balance between protein and organellar synthesis and their degradation. The autophagy-lysosome system is respon...
Citation: Skeletal Muscle 2022 12:13 -
The Myotube Analyzer: how to assess myogenic features in muscle stem cells
The analysis of in vitro cultures of human adult muscle stem cells obtained from biopsies delineates the potential of skeletal muscles and may help to understand altered muscle morphology in patients. In these...
Citation: Skeletal Muscle 2022 12:12 -
Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight
As the interest in manned spaceflight increases, so does the requirement to understand the transcriptomic mechanisms that underlay the detrimental physiological adaptations of skeletal muscle to microgravity. ...
Citation: Skeletal Muscle 2022 12:11 -
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension
Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increases the risk of mortality. Growth differentiation factor 11 (GDF11), centrally involved...
Citation: Skeletal Muscle 2022 12:10 -
The Notch signaling network in muscle stem cells during development, homeostasis, and disease
Skeletal muscle stem cells have a central role in muscle growth and regeneration. They reside as quiescent cells in resting muscle and in response to damage they transiently amplify and fuse to produce new myo...
Citation: Skeletal Muscle 2022 12:9 -
Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress
Radiotherapy is commonly used to treat childhood cancers and can have adverse effects on muscle function, but the underlying mechanisms have yet to be fully elucidated. We hypothesized that endurance exercise ...
Citation: Skeletal Muscle 2022 12:8 -
Functional replacement of myostatin with GDF-11 in the germline of mice
Myostatin (MSTN) is a transforming growth factor-ß superfamily member that acts as a major regulator of skeletal muscle mass. GDF-11, which is highly related to MSTN, plays multiple roles during embryonic deve...
Citation: Skeletal Muscle 2022 12:7 -
Effect of chronic intermittent hypoxia (CIH) on neuromuscular junctions and mitochondria in slow- and fast-twitch skeletal muscles of mice—the role of iNOS
Obstructive sleep apnea (OSA) imposes vascular and metabolic risks through chronic intermittent hypoxia (CIH) and impairs skeletal muscle performance. As studies addressing limb muscles are rare, the reasons f...
Citation: Skeletal Muscle 2022 12:6 -
Muscle stem cell adaptations to cellular and environmental stress
Lifelong regeneration of the skeletal muscle is dependent on a rare population of resident skeletal muscle stem cells, also named ‘satellite cells’ for their anatomical position on the outside of the myofibre ...
Citation: Skeletal Muscle 2022 12:5 -
Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years
Skeletal muscles are essential components of the neuromuscular skeletal system that have an integral role in the structure and function of the synovial joints which are often affected by osteoarthritis (OA). T...
Citation: Skeletal Muscle 2022 12:4 -
Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing
Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The efficiency of this process declines with age contributing to neuromuscular deficits. This study investigated...
Citation: Skeletal Muscle 2022 12:3 -
Novel γ-sarcoglycan interactors in murine muscle membranes
The sarcoglycan complex (SC) is part of a network that links the striated muscle cytoskeleton to the basal lamina across the sarcolemma. The SC coordinates changes in phosphorylation and Ca++-flux during mechanic...
Citation: Skeletal Muscle 2022 12:2 -
Meeting report: the 2021 FSHD International Research Congress
Facioscapulohumeral muscular dystrophy (FSHD) is the second most common genetic myopathy, characterized by slowly progressing and highly heterogeneous muscle wasting with a typical onset in the late teens/earl...
Citation: Skeletal Muscle 2022 12:1 -
ViaFuse: Fiji macros to calculate skeletal muscle cell viability and fusion index
Measuring biological features of skeletal muscle cells is difficult because of their unique morphology and multinucleate nature upon differentiation. Here, we developed a new Fiji macro package called ViaFuse ...
Citation: Skeletal Muscle 2021 11:28 -
Evaluation of the mechanisms of sarcopenia in chronic inflammatory disease: protocol for a prospective cohort study
Several chronic inflammatory diseases co-exist with and accelerate sarcopenia (reduction in muscle strength, function and mass) and negatively impact on both morbidity and mortality. There is currently limited...
Citation: Skeletal Muscle 2021 11:27 -
Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter
The Six1 transcription factor is implicated in controlling the development of several tissue types, notably skeletal muscle. Six1 also contributes to muscle metabolism and its activity is associated with the fast...
Citation: Skeletal Muscle 2021 11:26 -
The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following ...
Citation: Skeletal Muscle 2021 11:25 -
Protein profile of fiber types in human skeletal muscle: a single-fiber proteomics study
Human skeletal muscle is composed of three major fiber types, referred to as type 1, 2A, and 2X fibers. This heterogeneous cellular composition complicates the interpretation of studies based on whole skeletal...
Citation: Skeletal Muscle 2021 11:24 -
Improved CRISPR/Cas9 gene editing in primary human myoblasts using low confluency cultures on Matrigel
CRISPR/Cas9 is an invaluable tool for studying cell biology and the development of molecular therapies. However, delivery of CRISPR/Cas9 components into some cell types remains a major hurdle. Primary human my...
Citation: Skeletal Muscle 2021 11:23 -
Preservation of satellite cell number and regenerative potential with age reveals locomotory muscle bias
Although muscle regenerative capacity declines with age, the extent to which this is due to satellite cell-intrinsic changes vs. environmental changes has been controversial. The majority of aging studies have...
Citation: Skeletal Muscle 2021 11:22 -
Simvastatin does not alleviate muscle pathology in a mouse model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an incurable disease, caused by the mutations in the DMD gene, encoding dystrophin, an actin-binding cytoskeletal protein. Lack of functional dystrophin results in muscle weak...
Citation: Skeletal Muscle 2021 11:21 -
Investigating the correlation of muscle function tests and sarcomere organization in C. elegans
Caenorhabditis elegans has been widely used as a model to study muscle structure and function. Its body wall muscle is functionally and structurally similar to vertebrate skeletal muscle with conserved molecular ...
Citation: Skeletal Muscle 2021 11:20 -
The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene
In the search of genetic determinants of Duchenne muscular dystrophy (DMD) severity, LTBP4, a member of the latent TGF-β binding protein family, emerged as an important predictor of functional outcome trajectorie...
Citation: Skeletal Muscle 2021 11:19 -
mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation
During skeletal muscle regeneration, satellite stem cells use distinct pathways to repair damaged myofibers or to self-renew by returning to quiescence. Cellular/mitotic quiescence employs mechanisms that prom...
Citation: Skeletal Muscle 2021 11:18 -
Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release
Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments. This long-term process could be shortened by the drug-r...
Citation: Skeletal Muscle 2021 11:17 -
Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions
Striated muscle is a highly plastic and regenerative organ that regulates body movement, temperature, and metabolism—all the functions needed for an individual’s health and well-being. The muscle connective ti...
Citation: Skeletal Muscle 2021 11:16 -
Niclosamide ethanolamine ameliorates diabetes-related muscle wasting by inhibiting autophagy
Diabetes-related muscle wasting is one of the devastating complications of diabetes, which is associated with muscle autophagy due to insulin-mediated glucose starvation. However, treatment for diabetes-relate...
Citation: Skeletal Muscle 2021 11:15 -
Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis
The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4). Because IL-4 is an esse...
Citation: Skeletal Muscle 2021 11:14 -
Single cell RNA-seq analysis of the flexor digitorum brevis mouse myofibers
Skeletal muscle myofibers can be separated into functionally distinct cell types that differ in gene and protein expression. Current single cell expression data is generally based upon single nucleus RNA, rath...
Citation: Skeletal Muscle 2021 11:13 -
Nanopattern surface improves cultured human myotube maturation
In vitro maturation of human primary myoblasts using 2D culture remains a challenging process and leads to immature fibers with poor internal organization and function. This would however represent a valuable sys...
Citation: Skeletal Muscle 2021 11:12 -
Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study
Old age is associated with a significantly increased mortality in COVID-19 patients exposed to long-term controlled mechanical ventilation (CMV) and suggested to be due to the hyperinflammatory response associ...
Citation: Skeletal Muscle 2021 11:11 -
Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature
SARS-CoV2 virus could be potentially myopathic. Serum creatinine phosphokinase (CPK) is frequently found elevated in severe SARS-CoV2 infection, which indicates skeletal muscle damage precipitating limb weakne...
Citation: Skeletal Muscle 2021 11:10 -
Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction
ALAS2 (delta-aminolevulinate synthase 2) is one of the two isoenzymes catalyzing the synthesis of delta-aminolevulinic acid (ALA), which is the first precursor of heme synthesis. ALAS2-overexpressing transgeni...
Citation: Skeletal Muscle 2021 11:9 -
Retraction Note to: Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice
An amendment to this paper has been published and can be accessed via the original article.
Citation: Skeletal Muscle 2021 11:8 -
A novel approach for the isolation and long-term expansion of pure satellite cells based on ice-cold treatment
Satellite cells (SCs) are muscle stem cells capable of regenerating injured muscle. The study of their functional potential depends on the availability of methods for the isolation and expansion of pure SCs wi...
Citation: Skeletal Muscle 2021 11:7 -
MiR-1290 promotes myoblast differentiation and protects against myotube atrophy via Akt/p70/FoxO3 pathway regulation
Sarcopenia is a common skeletal disease related to myogenic disorders and muscle atrophy. Current clinical management has limited effectiveness. We sought to investigate the role of miR-1290 in myoblast differ...
Citation: Skeletal Muscle 2021 11:6 -
Dynamics of myogenic differentiation using a novel Myogenin knock-in reporter mouse
Myogenin is a transcription factor that is expressed during terminal myoblast differentiation in embryonic development and adult muscle regeneration. Investigation of this cell state transition has been hampered ...
Citation: Skeletal Muscle 2021 11:5 -
Epigenetic regulation of satellite cell fate during skeletal muscle regeneration
In response to muscle injury, muscle stem cells integrate environmental cues in the damaged tissue to mediate regeneration. These environmental cues are tightly regulated to ensure expansion of muscle stem cel...
Citation: Skeletal Muscle 2021 11:4 -
Muscle spindle function in healthy and diseased muscle
Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this i...
Citation: Skeletal Muscle 2021 11:3 -
Sarcoglycan A mutation in miniature dachshund dogs causes limb-girdle muscular dystrophy 2D
A cohort of related miniature dachshund dogs with exercise intolerance, stiff gait, dysphagia, myoglobinuria, and markedly elevated serum creatine kinase activities were identified.
Citation: Skeletal Muscle 2021 11:2 -
Analysis of human satellite cell dynamics on cultured adult skeletal muscle myofibers
Maintaining stem cells in physiologically relevant states is necessary to understand cell and context-specific signalling paradigms and to understand complex interfaces between cells in situ. Understanding hum...
Citation: Skeletal Muscle 2021 11:1 -
Mitochondrial dysfunction and consequences in calpain-3-deficient muscle
Nonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, ...
Citation: Skeletal Muscle 2020 10:37 -
Meeting report: the 2020 FSHD International Research Congress
Citation: Skeletal Muscle 2020 10:36 -
The role of Nrf2 in acute and chronic muscle injury
The nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as a master cytoprotective factor regulating the expression of genes encoding anti-oxidant, anti-inflammatory, and detoxifying proteins. The...
Citation: Skeletal Muscle 2020 10:35 -
Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function
Tetraspanins are a family of proteins known to assemble protein complexes at the cell membrane. They are thought to play diverse cellular functions in tissues by modifying protein-binding partners, thus bringi...
Citation: Skeletal Muscle 2020 10:34 -
MyoSight—semi-automated image analysis of skeletal muscle cross sections
Manual analysis of cross-sectional area, fiber-type distribution, and total and centralized nuclei in skeletal muscle cross sections is tedious and time consuming, necessitating an accurate, automated method o...
Citation: Skeletal Muscle 2020 10:33 -
Ryanodine receptor 1-related disorders: an historical perspective and proposal for a unified nomenclature
The RYR1 gene, which encodes the sarcoplasmic reticulum calcium release channel or type 1 ryanodine receptor (RyR1) of skeletal muscle, was sequenced in 1988 and RYR1 variations that impair calcium homeostasis an...
Citation: Skeletal Muscle 2020 10:32 -
In remembrance of David Yaffe
Citation: Skeletal Muscle 2020 10:31