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  1. Research

    Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy

    Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin expression and leads to severe ambulatory and cardiac function decline. However, the dystrophin-deficient mdx murine model of DMD only develops a ...

    Nadia Milad, Zoe White, Arash Y. Tehrani, Stephanie Sellers, Fabio M.V. Rossi and Pascal Bernatchez

    Skeletal Muscle 2017 7:19

    Published on: 12 September 2017

  2. Research

    Fragile X mental retardation protein regulates skeletal muscle stem cell activity by regulating the stability of Myf5 mRNA

    Regeneration of adult tissues relies on adult stem cells that are primed to enter a differentiation program, while typically remaining quiescent. In mouse skeletal muscle, these features are reconciled by mult...

    Ryo Fujita, Victoria Zismanov, Jean-Marie Jacob, Solène Jamet, Krum Asiev and Colin Crist

    Skeletal Muscle 2017 7:18

    Published on: 7 September 2017

  3. Research

    BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells

    Facioscapulohumeral dystrophy (FSHD) is a progressive muscle disease caused by mutations that lead to epigenetic derepression and inappropriate transcription of the double homeobox 4 (DUX4) gene in skeletal muscl...

    Amy E. Campbell, Jonathan Oliva, Matthew P. Yates, Jun Wen Zhong, Sean C. Shadle, Lauren Snider, Nikita Singh, Shannon Tai, Yosuke Hiramuki, Rabi Tawil, Silvère M. van der Maarel, Stephen J. Tapscott and Francis M. Sverdrup

    Skeletal Muscle 2017 7:16

    Published on: 4 September 2017

  4. Research

    Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass

    In contrast to the acute effects of growth hormone (GH) on skeletal muscle protein synthesis, long-term GH treatment appears to have negligible effects on muscle mass. Despite this knowledge, little is known r...

    Leslie A. Consitt, Alicson Saneda, Gunjan Saxena, Edward O. List and John J. Kopchick

    Skeletal Muscle 2017 7:17

    Published on: 4 September 2017

  5. Research

    Exome sequencing reveals independent SGCD deletions causing limb girdle muscular dystrophy in Boston terriers

    Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of inherited autosomal myopathies that preferentially affect voluntary muscles of the shoulders and hips. LGMD has been clinically described i...

    Melissa L. Cox, Jacquelyn M. Evans, Alexander G. Davis, Ling T. Guo, Jennifer R. Levy, Alison N. Starr-Moss, Elina Salmela, Marjo K. Hytönen, Hannes Lohi, Kevin P. Campbell, Leigh Anne Clark and G. Diane Shelton

    Skeletal Muscle 2017 7:15

    Published on: 11 July 2017

  6. Research

    Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice

    Pax7+ satellite cells are required for skeletal muscle fiber growth during post-natal development in mice. Satellite cell-mediated myonuclear accretion also appears to persist into early adulthood. Given the i...

    Kevin A. Murach, Sarah H. White, Yuan Wen, Angel Ho, Esther E. Dupont-Versteegden, John J. McCarthy and Charlotte A. Peterson

    Skeletal Muscle 2017 7:14

    Published on: 10 July 2017

  7. Research

    Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

    Facioscapulohumeral muscular dystrophy (FSHD) is most commonly inherited in an autosomal dominant pattern and caused by the abnormal expression of DUX4 in skeletal muscle. The DUX4 transcription factor has DNA...

    Premi Haynes, Kelly Kernan, Suk-Lin Zhou and Daniel G. Miller

    Skeletal Muscle 2017 7:13

    Published on: 21 June 2017

  8. Research

    Nanospan, an alternatively spliced isoform of sarcospan, localizes to the sarcoplasmic reticulum in skeletal muscle and is absent in limb girdle muscular dystrophy 2F

    Sarcospan (SSPN) is a transmembrane protein that interacts with the sarcoglycans (SGs) to form a tight subcomplex within the dystrophin-glycoprotein complex that spans the sarcolemma and interacts with laminin...

    Angela K. Peter, Gaynor Miller, Joana Capote, Marino DiFranco, Alhondra Solares-Pérez, Emily L. Wang, Jim Heighway, Ramón M. Coral-Vázquez, Julio Vergara and Rachelle H. Crosbie-Watson

    Skeletal Muscle 2017 7:11

    Published on: 6 June 2017

  9. Research

    SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes

    Facioscapulohumeral muscular dystrophy (FSHD) is in most cases caused by a contraction of the D4Z4 macrosatellite repeat on chromosome 4 (FSHD1) or by mutations in the SMCHD1 or DNMT3B gene (FSHD2). Both situatio...

    Amanda G. Mason, Roderick C. Slieker, Judit Balog, Richard J. L. F. Lemmers, Chao-Jen Wong, Zizhen Yao, Jong-Won Lim, Galina N. Filippova, Enrico Ne, Rabi Tawil, Bas T. Heijmans, Stephen J. Tapscott and Silvère M. van der Maarel

    Skeletal Muscle 2017 7:12

    Published on: 6 June 2017

  10. Research

    Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

    The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through it...

    Haitao A. Wang, John D. Lee, Kah Meng Lee, Trent M. Woodruff and Peter G. Noakes

    Skeletal Muscle 2017 7:10

    Published on: 1 June 2017

  11. Review

    The golden retriever model of Duchenne muscular dystrophy

    Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the DMD gene and loss of the protein dystrophin. The absence of dystrophin leads to myofiber membrane fragility and necrosis, with e...

    Joe N. Kornegay

    Skeletal Muscle 2017 7:9

    Published on: 19 May 2017

  12. Research

    Retinoid acid-induced microRNA-31-5p suppresses myogenic proliferation and differentiation by targeting CamkIIδ

    We previously reported that Wnt5a/CaMKIIδ (calcium/calmodulin-dependent protein kinase II delta) pathway was involved in the embryonic tongue deformity induced by excess retinoic acid (RA). Our latest study fo...

    Bo Liu, Chao Liu, Wei Cong, Nan Li, Nan Zhou, Yi Tang, Chao Wei, Han Bai, Ying Zhang and Jing Xiao

    Skeletal Muscle 2017 7:8

    Published on: 11 May 2017

  13. Research

    Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation

    Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known t...

    Chehade Karam, Jianxun Yi, Yajuan Xiao, Kamal Dhakal, Lin Zhang, Xuejun Li, Carlo Manno, Jiejia Xu, Kaitao Li, Heping Cheng, Jianjie Ma and Jingsong Zhou

    Skeletal Muscle 2017 7:6

    Published on: 10 April 2017

  14. Research

    Linkages between changes in the 3D organization of the genome and transcription during myotube differentiation in vitro

    The spatial organization of eukaryotic genomes facilitates and reflects the underlying nuclear processes that are occurring in the cell. As such, the spatial organization of a genome represents a window on the...

    Malina D. Doynova, James F. Markworth, David Cameron-Smith, Mark H. Vickers and Justin M. O’Sullivan

    Skeletal Muscle 2017 7:5

    Published on: 5 April 2017

  15. Research

    Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness

    The Ste20-like kinase, SLK, plays an important role in cell proliferation and cytoskeletal remodeling. In fibroblasts, SLK has been shown to respond to FAK/Src signaling and regulate focal adhesion turnover th...

    Benjamin R. Pryce, Khalid N. Al-Zahrani, Sébastien Dufresne, Natalya Belkina, Cédrik Labrèche, Genaro Patino-Lopez, Jérôme Frenette, Stephen Shaw and Luc A. Sabourin

    Skeletal Muscle 2017 7:3

    Published on: 2 February 2017

  16. Research

    Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice

    There is much interest in the capacity of resistance exercise to prevent the age-related loss of skeletal muscle mass and function, known as sarcopenia. This study investigates the molecular basis underlying t...

    Zoe White, Jessica Terrill, Robert B. White, Christopher McMahon, Phillip Sheard, Miranda D. Grounds and Tea Shavlakadze

    Skeletal Muscle 2016 6:45

    Published on: 13 December 2016

    The Erratum to this article has been published in Skeletal Muscle 2017 7:4

  17. Research

    Laminin 521 maintains differentiation potential of mouse and human satellite cell-derived myoblasts during long-term culture expansion

    Large-scale expansion of myogenic progenitors is necessary to support the development of high-throughput cellular assays in vitro and to advance genetic engineering approaches necessary to develop cellular the...

    Christopher M. Penton, Vasudeo Badarinarayana, Joy Prisco, Elaine Powers, Mark Pincus, Ronald E. Allen and Paul R. August

    Skeletal Muscle 2016 6:44

    Published on: 13 December 2016

  18. Research

    Skeletal muscle characteristics are preserved in hTERT/cdk4 human myogenic cell lines

    hTERT/cdk4 immortalized myogenic human cell lines represent an important tool for skeletal muscle research, being used as therapeutically pertinent models of various neuromuscular disorders and in numerous fun...

    Matthew Thorley, Stéphanie Duguez, Emilia Maria Cristina Mazza, Sara Valsoni, Anne Bigot, Kamel Mamchaoui, Brennan Harmon, Thomas Voit, Vincent Mouly and William Duddy

    Skeletal Muscle 2016 6:43

    Published on: 8 December 2016

  19. Research

    CCAAT/enhancer binding protein β is required for satellite cell self-renewal

    Postnatal growth and repair of skeletal muscle relies upon a population of quiescent muscle precursor cells, called satellite cells that can be activated to proliferate and differentiate into new myofibers, as...

    Neena Lala-Tabbert, Hamood AlSudais, François Marchildon, Dechen Fu and Nadine Wiper-Bergeron

    Skeletal Muscle 2016 6:40

    Published on: 7 December 2016

  20. Research

    Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4

    Nuclear bodies, such as nucleoli, PML bodies, and SC35 speckles, are dynamic sub-nuclear structures that regulate multiple genetic and epigenetic processes. Additional regulation is provided by RNA/DNA handlin...

    Sachiko Homma, Mary Lou Beermann, Bryant Yu, Frederick M. Boyce and Jeffrey Boone Miller

    Skeletal Muscle 2016 6:42

    Published on: 1 December 2016

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