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  1. Content type: Research

    Duchenne muscular dystrophy (DMD) is a genetic disease evoked by a mutation in the dystrophin gene. It is associated with progressive muscle degeneration and increased inflammation. Up to this date, mainly ant...

    Authors: Iwona Bronisz-Budzyńska, Katarzyna Chwalenia, Olga Mucha, Paulina Podkalicka, Karolina-Bukowska-Strakova, Alicja Józkowicz, Agnieszka Łoboda, Magdalena Kozakowska and Józef Dulak

    Citation: Skeletal Muscle 2019 9:22

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  2. Content type: Research

    Secondary dystroglycanopathies are muscular dystrophies that result from mutations in genes that participate in Dystroglycan glycosylation. Glycosylation of Dystroglycan is essential for muscle fibers to adher...

    Authors: Erin C. Bailey, Sarah S. Alrowaished, Elisabeth A. Kilroy, Emma S. Crooks, Daisy M. Drinkert, Chaya M. Karunasiri, Joseph J. Belanger, Andre Khalil, Joshua B. Kelley and Clarissa A. Henry

    Citation: Skeletal Muscle 2019 9:21

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  3. Content type: Research

    Estrogen signaling is indispensable for muscle regeneration, yet the role of estrogen in the development of muscle inflammation, especially in the intramuscular T cell response, and the influence on the intrin...

    Authors: Zhao Hong Liao, Tao Huang, Jiang Wei Xiao, Rui Cai Gu, Jun Ouyang, Gang Wu and Hua Liao

    Citation: Skeletal Muscle 2019 9:20

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  4. Content type: Research

    Sexually dimorphic growth has been attributed to the growth hormone (GH)/insulin-like growth factor 1 (IGF1) axis, particularly GH-induced activation of the intracellular signal transducer and activator of tra...

    Authors: Ryan G. Paul, Alex S. Hennebry, Marianne S. Elston, John V. Conaglen and Chris D. McMahon

    Citation: Skeletal Muscle 2019 9:19

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  5. Content type: Research

    Trauma-induced heterotopic ossification (HO) is a complication that develops under three conditions: the presence of an osteogenic progenitor cell, an inducing factor, and a permissive environment. We previous...

    Authors: Geneviève Drouin, Vanessa Couture, Marc-Antoine Lauzon, Frédéric Balg, Nathalie Faucheux and Guillaume Grenier

    Citation: Skeletal Muscle 2019 9:18

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  6. Content type: Research

    Skeletal muscle contributes to roughly 40% of lean body mass, and its loss contributes to morbidity and mortality in a variety of pathogenic conditions. Significant insights into muscle function have been made...

    Authors: Lance T. Denes, Lance A. Riley, Joseph R. Mijares, Juan D. Arboleda, Kendra McKee, Karyn A. Esser and Eric T. Wang

    Citation: Skeletal Muscle 2019 9:17

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  7. Content type: Research

    Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor β superfamily. The GDF11 propeptide, which is derived from the GDF11 precursor protein, blocks the activity of GDF11 and i...

    Authors: Quan Jin, Chunping Qiao, Jianbin Li, Bin Xiao, Juan Li and Xiao Xiao

    Citation: Skeletal Muscle 2019 9:16

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  8. Content type: Research

    The quantitative analysis of muscle histomorphometry has been growing in importance in both research and clinical settings. Accurate and stringent assessment of myofibers’ changes in size and number, and alter...

    Authors: Perla C. Reyes-Fernandez, Baptiste Periou, Xavier Decrouy, Fréderic Relaix and François Jérôme Authier

    Citation: Skeletal Muscle 2019 9:15

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  9. Content type: Case Report

    Myopalladin (MYPN) is a component of the sarcomere that tethers nebulin in skeletal muscle and nebulette in cardiac muscle to alpha-actinin at the Z lines. Autosomal dominant MYPN mutations cause hypertrophic, di...

    Authors: Luciano Merlini, Patrizia Sabatelli, Manuela Antoniel, Valeria Carinci, Fabio Niro, Giuseppe Monetti, Annalaura Torella, Teresa Giugliano, Cesare Faldini and Vincenzo Nigro

    Citation: Skeletal Muscle 2019 9:14

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  10. Content type: Research

    Skeletal muscle atrophy is a pathological condition that contributes to morbidity in a variety of conditions including denervation, cachexia, and aging. Muscle atrophy is characterized as decreased muscle fibe...

    Authors: Neena Lala-Tabbert, Rim Lejmi-Mrad, Kristen Timusk, Marina Fukano, Janelle Holbrook, Martine St-Jean, Eric C. LaCasse and Robert G. Korneluk

    Citation: Skeletal Muscle 2019 9:13

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  11. Content type: Research

    Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric cancer population. Survival among metastatic RMS patients has remained dismal yet unimproved for years. We previously identified t...

    Authors: Narendra Bharathy, Noah E. Berlow, Eric Wang, Jinu Abraham, Teagan P. Settelmeyer, Jody E. Hooper, Matthew N. Svalina, Zia Bajwa, Martin W. Goros, Brian S. Hernandez, Johannes E. Wolff, Ranadip Pal, Angela M. Davies, Arya Ashok, Darnell Bushby, Maria Mancini…

    Citation: Skeletal Muscle 2019 9:12

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  12. Content type: Research

    α-Dystroglycan is the highly glycosylated component of the dystrophin-glycoprotein complex (DGC) that binds with high-affinity to extracellular matrix (ECM) proteins containing laminin-G-like (LG) domains via ...

    Authors: Daniel Beltrán, Mary E. Anderson, Narendra Bharathy, Teagan P. Settelmeyer, Matthew N. Svalina, Zia Bajwa, John F. Shern, Sakir H. Gultekin, Marco A. Cuellar, Takahiro Yonekawa, Charles Keller and Kevin P. Campbell

    Citation: Skeletal Muscle 2019 9:11

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  14. Content type: Research

    Critical illness myopathy (CIM) is associated with severe skeletal muscle wasting and impaired function in intensive care unit (ICU) patients. The mechanisms underlying CIM remain incompletely understood. To e...

    Authors: Monica Llano-Diez, Wen Fury, Haruka Okamoto, Yu Bai, Jesper Gromada and Lars Larsson

    Citation: Skeletal Muscle 2019 9:9

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  15. Content type: Research

    Cancer cachexia as a metabolic syndrome can lead to at least 25% of cancer deaths. The inhibition of muscle atrophy is a main strategy to treat cancer cachexia. In this process, myostatin (MSTN) can exert a du...

    Authors: Dong Liu, Xinran Qiao, Zhijuan Ge, Yue Shang, Yi Li, Wendie Wang, Minghua Chen, Shuyi Si and Shu-zhen Chen

    Citation: Skeletal Muscle 2019 9:8

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  16. Content type: Review

    Striated muscles express an array of sarcomeric myosin motors that are tuned to accomplish specific tasks. Each myosin isoform found in muscle fibers confers unique contractile properties to the fiber in order...

    Authors: Lindsey A. Lee, Anastasia Karabina, Lindsey J. Broadwell and Leslie A. Leinwand

    Citation: Skeletal Muscle 2019 9:7

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  17. Content type: Research

    Osteopontin is secreted by skeletal muscle myoblasts and macrophages, and its expression is upregulated in muscle following injury. Osteopontin is present in many different structural forms, which vary in thei...

    Authors: Dimuthu K. Wasgewatte Wijesinghe, Eleanor J. Mackie and Charles N. Pagel

    Citation: Skeletal Muscle 2019 9:6

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  18. Content type: Research

    Group I Paks are serine/threonine kinases that function as major effectors of the small GTPases Rac1 and Cdc42, and they regulate cytoskeletal dynamics, cell polarity, and transcription. We previously demonstr...

    Authors: Giselle A. Joseph, Margaret Hung, Aviva J. Goel, Mingi Hong, Marysia-Kolbe Rieder, Noam D. Beckmann, Madhavika N. Serasinghe, Jerry E. Chipuk, Parvathi M. Devarakonda, David J. Goldhamer, Paulina Aldana-Hernandez, Jonathan Curtis, René L. Jacobs and Robert S. Krauss

    Citation: Skeletal Muscle 2019 9:5

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  19. Content type: Research

    Skeletal muscle myopathy and exercise intolerance are diagnostic hallmarks of heart failure (HF). However, the molecular adaptations of skeletal muscles during dilated cardiomyopathy (DCM)-mediated HF are not ...

    Authors: Taejeong Song, Palanikumar Manoharan, Douglas P. Millay, Sheryl E. Koch, Jack Rubinstein, Judith A. Heiny and Sakthivel Sadayappan

    Citation: Skeletal Muscle 2019 9:4

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  21. Content type: Methodology

    Adult skeletal muscle is capable of complete regeneration after an acute injury. The main parameter studied to assess muscle regeneration efficacy is the cross-sectional area (CSA) of the myofibers as myofiber...

    Authors: Thibaut Desgeorges, Sophie Liot, Solene Lyon, Jessica Bouvière, Alix Kemmel, Aurélie Trignol, David Rousseau, Bruno Chapuis, Julien Gondin, Rémi Mounier, Bénédicte Chazaud and Gaëtan Juban

    Citation: Skeletal Muscle 2019 9:2

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  22. Content type: Research

    Niemann-Pick disease type A (NPDA), a disease caused by mutations in acid sphingomyelinase (ASM), involves severe neurodegeneration and early death. Intracellular lipid accumulation and plasma membrane alterat...

    Authors: V. Michailowsky, H. Li, B. Mittra, S. R. Iyer, D. A. G. Mazála, M. Corrotte, Y. Wang, E. R. Chin, R. M. Lovering and N. W. Andrews

    Citation: Skeletal Muscle 2019 9:1

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  23. Content type: Research

    β2-adrenergic receptors (β2ARs) are the target of catecholamines and play fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An important action of β2AR stimulation on skeletal muscle...

    Authors: Jihee Kim, Chad A. Grotegut, James W. Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B. Rosenberg, Howard A. Rockman and Robert J. Lefkowitz

    Citation: Skeletal Muscle 2018 8:39

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  24. Content type: Correction

    Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article.

    Authors: Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller…

    Citation: Skeletal Muscle 2018 8:38

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    The original article was published in Skeletal Muscle 2018 8:35

  25. Content type: Research

    Members of the ZFP36 family of RNA-binding proteins regulate gene expression post-transcriptionally by binding to AU-rich elements in the 3’UTR of mRNA and stimulating mRNA degradation. The proteins within thi...

    Authors: Hema Bye-A-Jee, Dhamayanthi Pugazhendhi, Samuel Woodhouse, Patrick Brien, Rachel Watson, Martin Turner and Jennifer Pell

    Citation: Skeletal Muscle 2018 8:37

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  27. Content type: Research

    In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable...

    Authors: Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller…

    Citation: Skeletal Muscle 2018 8:35

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    The Correction to this article has been published in Skeletal Muscle 2018 8:38

  28. Content type: Research

    Myostatin antagonists are being developed as therapies for Duchenne muscular dystrophy due to their strong hypertrophic effects on skeletal muscle. Engineered follistatin has the potential to combine the hyper...

    Authors: Andrea Iskenderian, Nan Liu, Qingwei Deng, Yan Huang, Chuan Shen, Kathleen Palmieri, Robert Crooker, Dianna Lundberg, Niksa Kastrapeli, Brian Pescatore, Alla Romashko, John Dumas, Robert Comeau, Angela Norton, Jing Pan, Haojing Rong…

    Citation: Skeletal Muscle 2018 8:34

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  29. Content type: Methodology

    The tetracycline-responsive system (Tet-ON/OFF) has proven to be a valuable tool for manipulating gene expression in an inducible, temporal, and tissue-specific manner. The purpose of this study was to create ...

    Authors: Masahiro Iwata, Davis A. Englund, Yuan Wen, Cory M. Dungan, Kevin A. Murach, Ivan J. Vechetti Jr, Christopher B. Mobley, Charlotte A. Peterson and John J. McCarthy

    Citation: Skeletal Muscle 2018 8:33

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  30. Content type: Software

    Histological assessment of skeletal muscle sections is important for the research of muscle physiology and diseases. Quantifiable measures of skeletal muscle often include mean fiber diameter, fiber size distr...

    Authors: Yeh Siang Lau, Li Xu, Yandi Gao and Renzhi Han

    Citation: Skeletal Muscle 2018 8:32

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  31. Content type: Review

    The scientific premise, design, and structure-function analysis of chemical-based muscle membrane stabilizing block copolymers are reviewed here for applications in striated muscle membrane injury. Synthetic b...

    Authors: Evelyne M. Houang, Yuk Y. Sham, Frank S. Bates and Joseph M. Metzger

    Citation: Skeletal Muscle 2018 8:31

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  32. Content type: Research

    The skeletal muscle fiber has a specific and precise intracellular organization which is at the basis of an efficient muscle contraction. Microtubules are long known to play a major role in the function and or...

    Authors: Muriel Sébastien, Benoit Giannesini, Perrine Aubin, Julie Brocard, Mathilde Chivet, Laura Pietrangelo, Simona Boncompagni, Christophe Bosc, Jacques Brocard, John Rendu, Sylvie Gory-Fauré, Annie Andrieux, Anne Fourest-Lieuvin, Julien Fauré and Isabelle Marty

    Citation: Skeletal Muscle 2018 8:30

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  33. Content type: Research

    The formation of intrafusal muscle (IM) fibers and their contact with afferent proprioceptive axons is critical for construction, function, and maintenance of the stretch reflex. Many factors affect the format...

    Authors: Yuan Qiao, Menglin Cong, Jianmin Li, Hao Li and Zhenzhong Li

    Citation: Skeletal Muscle 2018 8:29

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  34. Content type: Research

    Caveolin-3 (CAV3) is a muscle-specific protein localized to the sarcolemma. It was suggested that CAV3 is involved in the connection between the extracellular matrix (ECM) and the cytoskeleton. Caveolinopathie...

    Authors: José Andrés González Coraspe, Joachim Weis, Mary E. Anderson, Ute Münchberg, Kristina Lorenz, Stephan Buchkremer, Stephanie Carr, René Peiman Zahedi, Eva Brauers, Hannah Michels, Yoshihide Sunada, Hanns Lochmüller, Kevin P. Campbell, Erik Freier, Denisa Hathazi and Andreas Roos

    Citation: Skeletal Muscle 2018 8:28

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  35. Content type: Research

    Pax7 is a transcription factor involved in the specification and maintenance of muscle stem cells (MuSCs). Upon injury, MuSCs leave their quiescent state, downregulate Pax7 and differentiate, contributing to s...

    Authors: Elisia D. Tichy, David K. Sidibe, Christopher D. Greer, Nicholas M. Oyster, Panteleimon Rompolas, Nadia A. Rosenthal, Helen M. Blau and Foteini Mourkioti

    Citation: Skeletal Muscle 2018 8:27

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  37. Content type: Methodology

    Skeletal muscle has the capacity to adapt to environmental changes and regenerate upon injury. To study these processes, most experimental methods use quantification of parameters obtained from images of immun...

    Authors: Alicia Mayeuf-Louchart, David Hardy, Quentin Thorel, Pascal Roux, Lorna Gueniot, David Briand, Aurélien Mazeraud, Adrien Bouglé, Spencer L. Shorte, Bart Staels, Fabrice Chrétien, Hélène Duez and Anne Danckaert

    Citation: Skeletal Muscle 2018 8:25

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  39. Content type: Research

    Dystroglycanopathies are a clinically and genetically heterogeneous group of disorders that are typically characterised by limb-girdle muscle weakness. Mutations in 18 different genes have been associated with...

    Authors: Katherine Johnson, Marta Bertoli, Lauren Phillips, Ana Töpf, Peter Van den Bergh, John Vissing, Nanna Witting, Shahriar Nafissi, Shirin Jamal-Omidi, Anna Łusakowska, Anna Kostera-Pruszczyk, Anna Potulska-Chromik, Nicolas Deconinck, Carina Wallgren-Pettersson, Sonja Strang-Karlsson, Jaume Colomer…

    Citation: Skeletal Muscle 2018 8:23

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  41. Content type: Methodology

    Duchenne muscular dystrophy (DMD) is a fatal, X-linked genetic disorder. Although DMD is the most common form of muscular dystrophy, only two FDA-approved drugs were developed to delay its progression. In orde...

    Authors: Lukasz Bozycki, Kacper Łukasiewicz, Paweł Matryba and Slawomir Pikula

    Citation: Skeletal Muscle 2018 8:21

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  42. Content type: Research

    Klotho is a well-known anti-aging hormone, which serves as a suppressor of aging through a variety of mechanisms. Aging of skeletal muscle is concomitant with a decrease in muscle stem cell function resulting ...

    Authors: Hellen E. Ahrens, Judith Huettemeister, Manuel Schmidt, Christoph Kaether and Julia von Maltzahn

    Citation: Skeletal Muscle 2018 8:20

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  43. Content type: Correction

    After publication of this article [1], the authors noted that the legends for supplementary files Figures S3 and S4 were truncated in the production process, therefore lacking some information concerning these...

    Authors: Natalia Pietrosemoli, Sébastien Mella, Siham Yennek, Meryem B. Baghdadi, Hiroshi Sakai, Ramkumar Sambasivan, Francesca Pala, Daniela Di Girolamo and Shahragim Tajbakhsh

    Citation: Skeletal Muscle 2018 8:19

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    The original article was published in Skeletal Muscle 2017 7:28

  44. Content type: Research

    A low-protein diet supplemented with ketoacids (LPD + KA) maintains the nutritional status of patients with chronic kidney disease (CKD). Oxidative damage and mitochondrial dysfunction associated with the upre...

    Authors: Dongtao Wang, Lianbo Wei, Yajun Yang and Huan Liu

    Citation: Skeletal Muscle 2018 8:18

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  45. Content type: Case report

    Transport protein particle (TRAPP) is a supramolecular protein complex that functions in localizing proteins to the Golgi compartment. The TRAPPC11 subunit has been implicated in muscle disease by virtue of ho...

    Authors: Austin A. Larson, Peter R. Baker II, Miroslav P. Milev, Craig A. Press, Ronald J. Sokol, Mary O. Cox, Jacqueline K. Lekostaj, Aaron A. Stence, Aaron D. Bossler, Jennifer M. Mueller, Keshika Prematilake, Thierry Fotsing Tadjo, Charles A. Williams, Michael Sacher and Steven A. Moore

    Citation: Skeletal Muscle 2018 8:17

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  46. Content type: Case report

    Boys with Duchenne muscular dystrophy (DMD) have DMD gene mutations, with associated loss of the dystrophin protein and progressive muscle degeneration and weakness. Corticosteroids and palliative support are cur...

    Authors: Sara Mata López, James J. Hammond, Madison B. Rigsby, Cynthia J. Balog-Alvarez, Joe N. Kornegay and Peter P. Nghiem

    Citation: Skeletal Muscle 2018 8:16

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  47. Content type: Research

    Duchenne (DMD) and Becker (BMD) muscular dystrophies are caused by mutations in the DMD gene coding for dystrophin, a protein being part of a large sarcolemmal protein scaffold that includes the neuronal nitric o...

    Authors: Marine Guilbaud, Christel Gentil, Cécile Peccate, Elena Gargaun, Isabelle Holtzmann, Carole Gruszczynski, Sestina Falcone, Kamel Mamchaoui, Rabah Ben Yaou, France Leturcq, Laurence Jeanson-Leh and France Piétri-Rouxel

    Citation: Skeletal Muscle 2018 8:15

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  48. Content type: Research

    The ability to assess skeletal muscle function and delineate regulatory mechanisms is essential to uncovering therapeutic approaches that preserve functional independence in a disease state. Skeletal muscle pr...

    Authors: Michael D. Tarpey, Adam J. Amorese, Nicholas P. Balestrieri, Terence E. Ryan, Cameron A. Schmidt, Joseph M. McClung and Espen E. Spangenburg

    Citation: Skeletal Muscle 2018 8:14

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  49. Content type: Research

    Fukutin-related protein (FKRP) mutations are the most common cause of dystroglycanopathies known to cause both limb girdle and congenital muscular dystrophy. The P448Lneo− mouse model has a knock-in mutation in t...

    Authors: Qing Yu, Melissa Morales, Ning Li, Alexander G. Fritz, Ren Ruobing, Anthony Blaeser, Ershia Francois, Qi-Long Lu, Kanneboyina Nagaraju and Christopher F. Spurney

    Citation: Skeletal Muscle 2018 8:13

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  50. Content type: Research

    A strength of Drosophila as a model system is its utility as a tool to screen for novel regulators of various functional and developmental processes. However, the utility of Drosophila as a screening tool is depe...

    Authors: Jaclyn M. Camuglia, Torrey R. Mandigo, Richard Moschella, Jenna Mark, Christine H. Hudson, Derek Sheen and Eric S. Folker

    Citation: Skeletal Muscle 2018 8:12

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