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  2. A common polymorphism (R577X) in the ACTN3 gene results in the complete absence of the Z-disc protein α-actinin-3 from fast-twitch muscle fibres in ~ 16% of the world’s population. This single gene polymorphism h...

    Authors: Michael Haug, Barbara Reischl, Stefanie Nübler, Leonit Kiriaev, Davi A. G. Mázala, Peter J. Houweling, Kathryn N. North, Oliver Friedrich and Stewart I. Head
    Citation: Skeletal Muscle 2022 12:14
    Content type: Research Published on:

  3. Aging decreases skeletal muscle mass and quality. Maintenance of healthy muscle is regulated by a balance between protein and organellar synthesis and their degradation. The autophagy-lysosome system is respon...

    Authors: Matthew Triolo, Ashley N. Oliveira, Rita Kumari and David A. Hood
    Citation: Skeletal Muscle 2022 12:13
    Content type: Research Published on:

  4. The analysis of in vitro cultures of human adult muscle stem cells obtained from biopsies delineates the potential of skeletal muscles and may help to understand altered muscle morphology in patients. In these...

    Authors: Simon Noë, Marlies Corvelyn, Sarah Willems, Domiziana Costamagna, Jean-Marie Aerts, Anja Van Campenhout and Kaat Desloovere
    Citation: Skeletal Muscle 2022 12:12
    Content type: Software Published on:

  5. As the interest in manned spaceflight increases, so does the requirement to understand the transcriptomic mechanisms that underlay the detrimental physiological adaptations of skeletal muscle to microgravity. ...

    Authors: Mason Henrich, Pin Ha, Yuanyuan Wang, Kang Ting, Louis Stodieck, Chia Soo, John S. Adams and Rene Chun
    Citation: Skeletal Muscle 2022 12:11
    Content type: Research Published on:

  6. Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increases the risk of mortality. Growth differentiation factor 11 (GDF11), centrally involved...

    Authors: Guiling Xiang, Kelu Ying, Pan Jiang, Mengping Jia, Yipeng Sun, Shanqun Li, Xiaodan Wu and Shengyu Hao
    Citation: Skeletal Muscle 2022 12:10
    Content type: Research Published on:

  8. Radiotherapy is commonly used to treat childhood cancers and can have adverse effects on muscle function, but the underlying mechanisms have yet to be fully elucidated. We hypothesized that endurance exercise ...

    Authors: Thomas N. O’Connor, Jacob G. Kallenbach, Haley M. Orciuoli, Nicole D. Paris, John F. Bachman, Carl J. Johnston, Eric Hernady, Jacqueline P. Williams, Robert T. Dirksen and Joe V. Chakkalakal
    Citation: Skeletal Muscle 2022 12:8
    Content type: Research Published on:

  9. Myostatin (MSTN) is a transforming growth factor-ß superfamily member that acts as a major regulator of skeletal muscle mass. GDF-11, which is highly related to MSTN, plays multiple roles during embryonic deve...

    Authors: Se-Jin Lee, Adam Lehar, Renata Rydzik, Daniel W. Youngstrom, Shalender Bhasin, Yewei Liu and Emily L. Germain-Lee
    Citation: Skeletal Muscle 2022 12:7
    Content type: Research Published on:

  10. Obstructive sleep apnea (OSA) imposes vascular and metabolic risks through chronic intermittent hypoxia (CIH) and impairs skeletal muscle performance. As studies addressing limb muscles are rare, the reasons f...

    Authors: L. I. Bannow, G. A. Bonaterra, M. Bertoune, S. Maus, R. Schulz, N. Weissmann, S. Kraut, R. Kinscherf and W. Hildebrandt
    Citation: Skeletal Muscle 2022 12:6
    Content type: Research Published on:

  12. Skeletal muscles are essential components of the neuromuscular skeletal system that have an integral role in the structure and function of the synovial joints which are often affected by osteoarthritis (OA). T...

    Authors: Salem Werdyani, Dawn Aitken, Zhiwei Gao, Ming Liu, Edward W. Randell, Proton Rahman, Graeme Jones and Guangju Zhai
    Citation: Skeletal Muscle 2022 12:4
    Content type: Research Published on:

  13. Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The efficiency of this process declines with age contributing to neuromuscular deficits. This study investigated...

    Authors: C. A. Staunton, E. D. Owen, K. Hemmings, A. Vasilaki, A. McArdle, R. Barrett-Jolley and M. J. Jackson
    Citation: Skeletal Muscle 2022 12:3
    Content type: Research Published on:

  14. The sarcoglycan complex (SC) is part of a network that links the striated muscle cytoskeleton to the basal lamina across the sarcolemma. The SC coordinates changes in phosphorylation and Ca++-flux during mechanic...

    Authors: Tara C. Smith, Georgios Vasilakos, Scott A. Shaffer, Jason M. Puglise, Chih-Hsuan Chou, Elisabeth R. Barton and Elizabeth J. Luna
    Citation: Skeletal Muscle 2022 12:2
    Content type: Research Published on:

  15. Facioscapulohumeral muscular dystrophy (FSHD) is the second most common genetic myopathy, characterized by slowly progressing and highly heterogeneous muscle wasting with a typical onset in the late teens/earl...

    Authors: Sujatha Jagannathan, Jessica C. de Greef, Lawrence J. Hayward, Kyoko Yokomori, Davide Gabellini, Karlien Mul, Sabrina Sacconi, Jamshid Arjomand, June Kinoshita and Scott Q. Harper
    Citation: Skeletal Muscle 2022 12:1
    Content type: Review Published on:

  16. Measuring biological features of skeletal muscle cells is difficult because of their unique morphology and multinucleate nature upon differentiation. Here, we developed a new Fiji macro package called ViaFuse ...

    Authors: Emma Rose Hinkle, Tasneem Omar Essader, Gabrielle Marie Gentile and Jimena Giudice
    Citation: Skeletal Muscle 2021 11:28
    Content type: Software Published on:

  17. Several chronic inflammatory diseases co-exist with and accelerate sarcopenia (reduction in muscle strength, function and mass) and negatively impact on both morbidity and mortality. There is currently limited...

    Authors: Amritpal Dhaliwal, Felicity R. Williams, Jonathan I. Quinlan, Sophie L. Allen, Carolyn Greig, Andrew Filer, Karim Raza, Subrata Ghosh, Gareth G. Lavery, Philip N. Newsome, Surabhi Choudhary, Leigh Breen, Matthew J. Armstrong, Ahmed M. Elsharkawy and Janet M. Lord
    Citation: Skeletal Muscle 2021 11:27
    Content type: Protocol Published on:

  18. The Six1 transcription factor is implicated in controlling the development of several tissue types, notably skeletal muscle. Six1 also contributes to muscle metabolism and its activity is associated with the fast...

    Authors: John Girgis, Dabo Yang, Imane Chakroun, Yubing Liu and Alexandre Blais
    Citation: Skeletal Muscle 2021 11:26
    Content type: Research Published on:

  19. As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following ...

    Authors: Hongyang Xu and Holly Van Remmen
    Citation: Skeletal Muscle 2021 11:25
    Content type: Review Published on:

  20. Human skeletal muscle is composed of three major fiber types, referred to as type 1, 2A, and 2X fibers. This heterogeneous cellular composition complicates the interpretation of studies based on whole skeletal...

    Authors: Marta Murgia, Leonardo Nogara, Martina Baraldo, Carlo Reggiani, Matthias Mann and Stefano Schiaffino
    Citation: Skeletal Muscle 2021 11:24
    Content type: Research Published on:

  21. CRISPR/Cas9 is an invaluable tool for studying cell biology and the development of molecular therapies. However, delivery of CRISPR/Cas9 components into some cell types remains a major hurdle. Primary human my...

    Authors: Hayley Goullée, Rhonda L. Taylor, Alistair R. R. Forrest, Nigel G. Laing, Gianina Ravenscroft and Joshua S. Clayton
    Citation: Skeletal Muscle 2021 11:23
    Content type: Methodology Published on:

  22. Although muscle regenerative capacity declines with age, the extent to which this is due to satellite cell-intrinsic changes vs. environmental changes has been controversial. The majority of aging studies have...

    Authors: Robert W. Arpke, Ahmed S. Shams, Brittany C. Collins, Alexie A. Larson, Nguyen Lu, Dawn A. Lowe and Michael Kyba
    Citation: Skeletal Muscle 2021 11:22
    Content type: Research Published on:

  23. Duchenne muscular dystrophy (DMD) is an incurable disease, caused by the mutations in the DMD gene, encoding dystrophin, an actin-binding cytoskeletal protein. Lack of functional dystrophin results in muscle weak...

    Authors: Olga Mucha, Paulina Podkalicka, Katarzyna Kaziród, Emilia Samborowska, Józef Dulak and Agnieszka Łoboda
    Citation: Skeletal Muscle 2021 11:21
    Content type: Research Published on:

  24. Caenorhabditis elegans has been widely used as a model to study muscle structure and function. Its body wall muscle is functionally and structurally similar to vertebrate skeletal muscle with conserved molecular ...

    Authors: Leila Lesanpezeshki, Hiroshi Qadota, Masoud Norouzi Darabad, Karishma Kashyap, Carla M. R. Lacerda, Nathaniel J. Szewczyk, Guy M. Benian and Siva A. Vanapalli
    Citation: Skeletal Muscle 2021 11:20
    Content type: Research Published on:

  25. In the search of genetic determinants of Duchenne muscular dystrophy (DMD) severity, LTBP4, a member of the latent TGF-β binding protein family, emerged as an important predictor of functional outcome trajectorie...

    Authors: Simonetta Andrea Licandro, Luca Crippa, Roberta Pomarico, Raffaella Perego, Gianluca Fossati, Flavio Leoni and Christian Steinkühler
    Citation: Skeletal Muscle 2021 11:19
    Content type: Research Published on:

  26. During skeletal muscle regeneration, satellite stem cells use distinct pathways to repair damaged myofibers or to self-renew by returning to quiescence. Cellular/mitotic quiescence employs mechanisms that prom...

    Authors: Nainita Roy, Swetha Sundar, Malini Pillai, Farah Patell-Socha, Sravya Ganesh, Ajoy Aloysius, Mohammed Rumman, Hardik Gala, Simon M. Hughes, Peter S. Zammit and Jyotsna Dhawan
    Citation: Skeletal Muscle 2021 11:18
    Content type: Research Published on:

  27. Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments. This long-term process could be shortened by the drug-r...

    Authors: Lin Zhou, Tong Zhang, Wei Shao, Ruohan Lu, Lin Wang, Haisheng Liu, Bin Jiang, Shiqin Li, Huiqin Zhuo, Suheng Wang, Qinxi Li, Caihua Huang and Donghai Lin
    Citation: Skeletal Muscle 2021 11:17
    Content type: Research Published on:

  28. Striated muscle is a highly plastic and regenerative organ that regulates body movement, temperature, and metabolism—all the functions needed for an individual’s health and well-being. The muscle connective ti...

    Authors: Osvaldo Contreras, Fabio M. V. Rossi and Marine Theret
    Citation: Skeletal Muscle 2021 11:16
    Content type: Review Published on:

  29. Diabetes-related muscle wasting is one of the devastating complications of diabetes, which is associated with muscle autophagy due to insulin-mediated glucose starvation. However, treatment for diabetes-relate...

    Authors: Yuchun Cai, Hongyue Zhan, Wenci Weng, Yao Wang, Pengxun Han, Xuewen Yu, Mumin Shao and Huili Sun
    Citation: Skeletal Muscle 2021 11:15
    Content type: Research Published on:

  30. The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4). Because IL-4 is an esse...

    Authors: Mitsutoshi Kurosaka, Yuji Ogura, Shuichi Sato, Kazuhisa Kohda and Toshiya Funabashi
    Citation: Skeletal Muscle 2021 11:14
    Content type: Research Published on:

  31. Skeletal muscle myofibers can be separated into functionally distinct cell types that differ in gene and protein expression. Current single cell expression data is generally based upon single nucleus RNA, rath...

    Authors: Rohan X. Verma, Suraj Kannan, Brian L. Lin, Katherine M. Fomchenko, Tim O. Nieuwenhuis, Arun H. Patil, Clarisse Lukban, Xiaoping Yang, Karen Fox-Talbot, Matthew N. McCall, Chulan Kwon, David A. Kass, Avi Z. Rosenberg and Marc K. Halushka
    Citation: Skeletal Muscle 2021 11:13
    Content type: Research Published on:

  32. In vitro maturation of human primary myoblasts using 2D culture remains a challenging process and leads to immature fibers with poor internal organization and function. This would however represent a valuable sys...

    Authors: Jessica Brunetti, Stéphane Koenig, Arthur Monnier and Maud Frieden
    Citation: Skeletal Muscle 2021 11:12
    Content type: Methodology Published on:

  33. Old age is associated with a significantly increased mortality in COVID-19 patients exposed to long-term controlled mechanical ventilation (CMV) and suggested to be due to the hyperinflammatory response associ...

    Authors: Qiong Lyu, Ya Wen, Xiang Zhang, Alex B. Addinsall, Nicola Cacciani and Lars Larsson
    Citation: Skeletal Muscle 2021 11:11
    Content type: Research Published on:

  35. ALAS2 (delta-aminolevulinate synthase 2) is one of the two isoenzymes catalyzing the synthesis of delta-aminolevulinic acid (ALA), which is the first precursor of heme synthesis. ALAS2-overexpressing transgeni...

    Authors: Yahui Peng, Jihong Li, Dixian Luo, Shuai Zhang, Sijia Li, Dayong Wang, Xidi Wang, Zhujun Zhang, Xue Wang, Changhui Sun, Xu Gao, Yang Hui and Rongzhang He
    Citation: Skeletal Muscle 2021 11:9
    Content type: Research Published on:

  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Adeel Safdar, Konstantin Khrapko, James M. Flynn, Ayesha Saleem, Michael De Lisio, Adam P. W. Johnston, Yevgenya Kratysberg, Imtiaz A. Samjoo, Yu Kitaoka, Daniel I. Ogborn, Jonathan P. Little, Sandeep Raha, Gianni Parise, Mahmood Akhtar, Bart P. Hettinga, Glenn C. Rowe…
    Citation: Skeletal Muscle 2021 11:8
    Content type: Retraction Note Published on:

    The original article was published in Skeletal Muscle 2016 6:7

  37. Satellite cells (SCs) are muscle stem cells capable of regenerating injured muscle. The study of their functional potential depends on the availability of methods for the isolation and expansion of pure SCs wi...

    Authors: Anna Benedetti, Gianluca Cera, Daniele De Meo, Ciro Villani, Marina Bouche and Biliana Lozanoska-Ochser
    Citation: Skeletal Muscle 2021 11:7
    Content type: Methodology Published on:

  38. Sarcopenia is a common skeletal disease related to myogenic disorders and muscle atrophy. Current clinical management has limited effectiveness. We sought to investigate the role of miR-1290 in myoblast differ...

    Authors: Ji Che, Cuidi Xu, Yuanyuan Wu, Peiyu Jia, Qi Han, Yantao Ma, Xiaolei Wang and Yongjun Zheng
    Citation: Skeletal Muscle 2021 11:6
    Content type: Research Published on:

  39. Myogenin is a transcription factor that is expressed during terminal myoblast differentiation in embryonic development and adult muscle regeneration. Investigation of this cell state transition has been hampered ...

    Authors: Maria Benavente-Diaz, Glenda Comai, Daniela Di Girolamo, Francina Langa and Shahragim Tajbakhsh
    Citation: Skeletal Muscle 2021 11:5
    Content type: Methodology Published on:

  41. Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this i...

    Authors: Stephan Kröger and Bridgette Watkins
    Citation: Skeletal Muscle 2021 11:3
    Content type: Review Published on:

  42. A cohort of related miniature dachshund dogs with exercise intolerance, stiff gait, dysphagia, myoglobinuria, and markedly elevated serum creatine kinase activities were identified.

    Authors: James R. Mickelson, Katie M. Minor, Ling T. Guo, Steven G. Friedenberg, Jonah N. Cullen, Amanda Ciavarella, Lydia E. Hambrook, Karen M. Brenner, Sarah E. Helmond, Stanley L. Marks and G. Diane Shelton
    Citation: Skeletal Muscle 2021 11:2
    Content type: Research Published on:

  44. Nonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, ...

    Authors: Vanessa E. Jahnke, Jennifer M. Peterson, Jack H. Van Der Meulen, Jessica Boehler, Kitipong Uaesoontrachoon, Helen K. Johnston, Aurelia Defour, Aditi Phadke, Qing Yu, Jyoti K. Jaiswal and Kanneboyina Nagaraju
    Citation: Skeletal Muscle 2020 10:37
    Content type: Research Published on:

  46. The nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as a master cytoprotective factor regulating the expression of genes encoding anti-oxidant, anti-inflammatory, and detoxifying proteins. The...

    Authors: Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Paulina Podkalicka, Neli Kachamakova-Trojanowska, Agnieszka Łoboda and Józef Dulak
    Citation: Skeletal Muscle 2020 10:35
    Content type: Research Published on:

  47. Tetraspanins are a family of proteins known to assemble protein complexes at the cell membrane. They are thought to play diverse cellular functions in tissues by modifying protein-binding partners, thus bringi...

    Authors: Arielle Hall, Tatiana Fontelonga, Alec Wright, Katlynn Bugda Gwilt, Jeffrey Widrick, Alessandra Pasut, Francesco Villa, Cynthia K. Miranti, Devin Gibbs, Evan Jiang, Hui Meng, Michael W. Lawlor and Emanuela Gussoni
    Citation: Skeletal Muscle 2020 10:34
    Content type: Research Published on:

  49. The RYR1 gene, which encodes the sarcoplasmic reticulum calcium release channel or type 1 ryanodine receptor (RyR1) of skeletal muscle, was sequenced in 1988 and RYR1 variations that impair calcium homeostasis an...

    Authors: Tokunbor A. Lawal, Joshua J. Todd, Jessica W. Witherspoon, Carsten G. Bönnemann, James J. Dowling, Susan L. Hamilton, Katherine G. Meilleur and Robert T. Dirksen
    Citation: Skeletal Muscle 2020 10:32
    Content type: Review Published on:
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