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Featured Article: High-throughput muscle fiber typing from RNA sequencing data

Congratulations to author Svante Pääbo, who was awarded The Nobel Prize in Physiology or Medicine on October 3rd, 2022 for his work in human evolution, namely sequencing the genetic code of the Neanderthal and his discovery of the Denisovans. He is currently the Director at the Max Planck Institute for Evolutionary Anthropology, Germany. We are pleased to highlight a recently-published paper by Dr. Pääbo and colleagues in which a method based on muscle tissue RNA sequencing data (totRNAseq) to estimate the distribution of skeletal muscle fiber types from frozen human samples is described.

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Aims and scope

Skeletal Muscle is a peer-reviewed, open access, online journal that publishes articles investigating molecular mechanisms underlying the biology of skeletal muscle. A wide range of skeletal muscle biology is included: development, metabolism, the regulation of mass and function, aging, degeneration, dystrophy and regeneration. The emphasis is on understanding adult skeletal muscle, its maintenance, and its interactions with non-muscle cell types and regulatory modulators.

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Editor quotes

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Carmen Birchmeier, co-Editor- in-Chief

"Skeletal muscle provides a platform for work on basic mechanisms used during muscle development, regeneration disease and aging. I find the similarities and differences between developing and adult muscle stem cells particularly fascinating."

New Content ItemMarkus A Rüegg, co-Editor-in-Chief

"Skeletal Muscle publishes influential mechanistic and methodological papers in the field and has become an important journal for my own research. I hope to further strengthen the journal´s coverage of mechanisms involved in the pathology of neuromuscular diseases."

David Glass, co-Editor-in-Chief

"The goal of the journal is to understand how the skeletal muscle relevant cellular systems work, so that one might be able to improve human health and combat disease.”

 

Michael A Rudnicki, co-Editor-in-Chief

"Skeletal Muscle is an exciting journal that will provide a home for our field and facilitate better dissemination of research into the fundamental mechanisms regulating muscle development, regeneration and function."

Kevin P Campbell, Emeritus Editor-in-Chief

"I am fascinated by the molecular architecture and machinery of muscle cells, and I am constantly surprised by the number of cellular mechanisms that maintain muscle function. I am encouraged by these discoveries, too, because all of these mechanisms provide us with many possibilities for attacking the muscle disease.” 

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