Figure 1
From: From proteins to genes: immunoanalysis in the diagnosis of muscular dystrophies
Control tests for necrosis and regeneration. Expression of various markers of sarcolemmal integrity (β-spectrin) and regeneration (neonatal myosin heavy chain (Neo-MHC), utrophin and laminin α5) in serial sections of control, Duchenne muscular dystrophy (DMD) and limb girdle muscular dystrophy (LGMD)2B muscle. Arrows indicate abnormal immature fibres positive for Neo-MHC; stars highlight regenerating fibres at different stages. The pattern of expression of the regeneration markers is less defined in DMD muscle due to the overall upregulation of utrophin and laminin α5 and secondary loss of neuronal nitric oxide synthase (nNOS).