Figure 2

Mitochondrial dynamics are altered during the progression of cachexia. A) Representative Western blot of Mfn1, Mfn2 and FIS1 protein expression during the progression of cachexia. B) Mfn1, C) Mfn2 and D) FIS1 protein expression normalized to weight stable mice. E) Bax mRNA expression normalized to weight stable mice. Values are means ± SE. Significance was set at P <0.05. † Signifies the difference from WS groups. & Signifies the difference from mice with ≤5% body weight loss. $ Signifies the difference from mice with 6 to 19% body weight loss. WS, weight stable.