Figure 3

IL-6 inhibition attenuates the loss in mitochondrial content and biogenesis in the Apc^Min/+mouse. Wild-type and Apc^Min/+ mice were treated with an IL-6 receptor antibody for two weeks to inhibit IL-6 signaling. A) Mitochondrial content as determined by the mitochondrial:nuclear DNA ratio. B) Representative Western blot of Cytochrome C, Cox IV and PGC-1α protein in wild-type and Apc^Min/+ mice treated with an IL-6 receptor antibody or PBS control. C) Cytochrome C, D) CoxIV and E) PGC-1α protein expression normalized to wild-type PBS control mice. Values are means ± SE. Significance was set at P <0.05. *Signifies the difference within treatment. † Signifies the difference within genotype.