Figure 6

Exercise training reduces IL-6 induced alterations in mitochondria dynamics, apoptosis and FoxO phosphorylation. A) Representative Western blot of Mfn1, Mfn2 and FIS1 protein in the gastrocnemius of Apc^Min/+ mice. B) Mfn1, C) Mfn2 and D) FIS1 protein expression normalized to sedentary mice treated with the control vector. E) upper - Representative Western blot of total and phosphorylated FoxO proteins; lower - ratio of phosphorylated to total FoxO protein expression normalized to cage control mice. F) Bax mRNA expression. Data are normalized to cage control mice. Values are means ± SE. Significance was set at P <0.05. CC, cage control; ME, main effect; Wt, wild-type. *Signifies the difference from cage control vector mice.