Figure 2
From: Metabolic remodeling agents show beneficial effects in the dystrophin- deficient mdx mouse model
Effect of GW and AICAR on body mass, muscle mass, and behavioral activity. (A-D) Mass of vehicle control- (n = 8), GW- (n = 6), AICAR- (n = 8), and GW&AICAR-treated (n = 6) mice: mass of the whole body (A), quadriceps (B), soleus (C), and abdominal fat (D) after euthanasia. Grip strength was measured using a grid at 12 and 16 weeks of age: (E) Maximal forelimb grip strength, (F) normalized maximal forelimb strength, (G) maximal hind-limb grip strength, (H) normalized maximal hind-limb strength of all the groups. The overall activity of the mice was measured using the open-field Digiscan apparatus at 12 and 16 weeks of age: (I) movement time and (J) rest time activity. Behavioral activity is presented as a percentage of the initial activity measured at 12 weeks of age before treatment. Data are means ± SE. * P < 0.05 vs. vehicle-treated control mice. **P < 0.01 vs. vehicle-treated control mice. *** P < 0.001 vs. vehicle-treated control mice.