Figure 7

Eps15 homology domain-containing (EHD)1^−/−skeletal muscle shows normal pathology and generates average specific force. Panel (A) Stainnig of tibialis anterior (TA) skeletal muscle cryosections (8 μm) from three WT and three EHD1^−/− mice did not show no degeneration or regeneration of fibers in EHD1^−/− mice, as shown by the absence of centralized nuclei. There was an absence of infiltrating white blood cells, also suggesting normal pathology (hematoxylin and eosin). (B) The force generated during a muscle contraction was measured in vivo in three WT and three EHD1^−/− EDL and soleus muscles each. EHD1^−/− EDL and soleus muscles showed no deficit in the amount of force generated during a muscle contraction (n = 3 per group).