Figure 5

Classification of top quartile RNA binding proteins significantly regulated 12 h post-injury in satellite cells. Genes categorized with the GO term Molecular Function: RNA Binding that change expression ≥ two-fold (ANOVA P ≤ 0.01) comprise 22% (154 of 716) of the total GO category in wild type satellite cells but do not change significantly in Sdc4^−/− satellite cell during the first 12 h post-muscle injury (A). A minority of the identified genes increase in relative expression (B), while the majority of these genes decrease in their relative expression 12 h post-muscle injury (C). Upregulated and downregulated genes were further classified and plotted as splicing factors (green bars), positive mRNA regulators (blue bars), negative mRNA regulators (red bars), or multiple/other functions (black bars). The values plotted are for fold increase (B) or fold decrease (C )unique to wild type satellite cells occurring in the first 12 h post-muscle injury.