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Figure 2 | Skeletal Muscle

Figure 2

From: Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy

Figure 2

RyR1 in β-sarcoglycan deficient muscle is cysteine-nitrosylated, oxidized, and depleted of calstabin1. (A) Representative immunoblot of immunoprecipitated RyR1 from wild-type (WT) and β-sarcoglycan deficient (Sgcb−/−) EDL muscles. Antibodies against RyR1-S2844 phosphorylation (P*RyR1), cysteine-nitrosylated (Cys NO) proteins, calstabin1, and the protein oxidation marker 2,4- dinitrophenylhydrazone (DNP) was used. The muscle from a mouse treated with S107 is marked (+). (B) Bar graph showing average band intensities normalized to RyR1 expression (mean ± SEM, n = 3 for all groups).

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Skeletal Muscle

ISSN: 2044-5040

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