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Figure 3 | Skeletal Muscle

Figure 3

From: Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation

Figure 3

Cultured myoblasts expressing H222P lamin A have greater ERK1/2 activity after osmotic shock than those expressing wild-type lamin A. One hour after osmotic shock with D-sorbitol, protein extracts from C2C12 cells stably expressing flag-tagged wild-type lamin A (Lmna WT) and flag-tagged H222P lamin A (Lmna H222P) were analyzed by immunoblotting. Blots were probed with antibodies against phosphorylated ERK1/2 (pERK1/2), total ERK1/2 (ERK1/2) and Flag. The immunoblot shown is representative of three separately performed experiments.

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Skeletal Muscle

ISSN: 2044-5040

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