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Figure 1 | Skeletal Muscle

Figure 1

From: Genome-wide binding of the basic helix-loop-helix myogenic inhibitor musculin has substantial overlap with MyoD: implications for buffering activity

Figure 1

MSC has similar, but non-identical, DNA binding characteristics to MyoD and binds at many of the same genomic locations. (A) E-box motif enrichment of MSC and MyoD bound sites in RDs identifies a similar preference for central dinucleotide identity (GC and GG), but differing preferences in the E-box flanking nucleotides. (B) Comparison of the top 30,000 MyoD and MSC peaks in RDs demonstrates substantial overlap in the sites bound by each factor. Peaks were ranked by P value, and grouped into bins that increase by 3,000 peaks each time (that is, first the 3,000 most significant peaks are considered, than the 6,000 most significant, and so on). The fraction of the overlap is indicated by color, as depicted in the legend. (C) De novo motif analysis of peaks specific to MSC identifies an 8 bp motif (row 2) enriched at MSC-specific binding sites. The motif analysis compared MSC-specific binding sites to those sites that bound both MyoD and MSC. bp, base pair; fg.frac, bg.frac: fraction of foreground/background sequences that contain at least one motif occurrence; MSC, musculin; ratio, enriched/depleted ratio of motifs.

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Skeletal Muscle

ISSN: 2044-5040

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