Table 1 A/Description of primary baits
Protein name | Protein symbol and LGMD form | Bait domain coordinates (aa)* | Bait domain description |
|---|---|---|---|
calpain 3 | CAPN3 (LGMD2A) | T417-S643 | C2-like domain + exons15-16 |
M1-A822 | full length protein with the C129S mutation in the autocatalytic site | ||
dysferlin | DYSF (LGMD2B) | L2-I485 | N-terminal DYSF regions containing the first three C2 domains |
Q851-D1200 | central DYSF domain | ||
I1145-L2026 | C-terminal DYSF domain containing the last four C2 domains and excluding the transmembrane span | ||
γ- sarcoglycan | SGCG (LGMD2C) | M1-L36 | cytoplasmic domain |
α-sarcoglycan | SGCA (LGMD2D) | M313-H388 | cytoplasmic domain |
β-sarcoglycan | SGCB (LGMD2E) | E10-A65 | cytoplasmic domain |
δ-sarcoglycan | SGCD (LGMD2F) | E1-Y36 | cytoplasmic domain |
titin-cap (telethonin) | TCAP (LGMD2G) | M1-G167 | full length protein |
tripartite motif-containing 32 | TRIM32 (LGMD2H) | L66-P654 | full length protein minus the RING domain |
titin | TTN (LGMD2J) | V97-K469 | exons 4-8 from the Z-Disc region |
I741-G948 | exons 14-17 from the Z-Disc region | ||
R2120-L2564 | exons 28-33 from the Z-Disc region | ||
A8831-E9158 | exons 108-114 from the N2A-PEVK region | ||
T32840-I33423 | exons 358-363 from the Mline region | ||
ankyrin repeat domain 1 | ANKRD1 | M1-F319 | full length protein |
ezrin | EZR | M1-S536 | full length protein minus the actin-binding C-terminal domain |
F-box protein 32 (MAFbx) | FBXO32 | M1-F356 | full length protein |
tripartite motif-containing 63 (MuRF1) | TRIM63 | M1-Q354 | full length protein |